Physical and histological comparison of hydroxyapatite, carbonate apatite, and β-tricalcium phosphate bone substitutes

Kunio Ishikawa, Youji Miyamoto, Akira Tsuchiya, Koichiro Hayashi, Kanji Tsuru, Go Ohe

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Three commercially available artificial bone substitutes with different compositions, hydroxyapatite (HAp; Neobone®), carbonate apatite (CO 3 Ap; Cytrans®), and β-tricalcium phosphate (β-TCP; Cerasorb®), were compared with respect to their physical properties and tissue response to bone, using hybrid dogs. Both Neobone® (HAp) and Cerasorb® (β-TCP) were porous, whereas Cytrans® (CO 3 Ap) was dense. Crystallite size and specific surface area (SSA) of Neobone® (HAp), Cytrans® (CO 3 Ap), and Cerasorb® (β-TCP) were 75.4 ± 0.9 nm, 30.8 ± 0.8 nm, and 78.5 ± 7.5 nm, and 0.06 m 2 /g, 18.2 m 2 /g, and 1.0 m 2 /g, respectively. These values are consistent with the fact that both Neobone® (HAp) and Cerasorb® (β-TCP) are sintered ceramics, whereas Cytrans® (CO 3 Ap) is fabricated in aqueous solution. Dissolution in pH 5.3 solution mimicking Howship's lacunae was fastest in CO 3 Ap (Cytrans®), whereas dissolution in pH 7.3 physiological solution was fastest in β-TCP (Cerasorb®). These results indicated that CO 3 Ap is stable under physiological conditions and is resorbed at Howship's lacunae. Histological evaluation using hybrid dog mandible bone defect model revealed that new bone was formed from existing bone to the center of the bone defect when reconstructed with CO 3 Ap (Cytrans®) at week 4. The amount of bone increased at week 12, and resorption of the CO 3 Ap (Cytrans®) was confirmed. β-TCP (Cerasorb®) showed limited bone formation at week 4. However, a larger amount of bone was observed at week 12. Among these three bone substitutes, CO 3 Ap (Cytrans®) demonstrated the highest level of new bone formation. These results indicate the possibility that bone substitutes with compositions similar to that of bone may have properties similar to those of bone.

Original languageEnglish
Article number1993
JournalMaterials
Volume11
Issue number10
DOIs
Publication statusPublished - Oct 16 2018

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Bone Substitutes
Apatite
Durapatite
Hydroxyapatite
Carbon Monoxide
Carbonates
Bone
Phosphates
Dissolution
carboapatite
tricalcium phosphate
Defects
Crystallite size
Chemical analysis
Specific surface area
beta-tricalcium phosphate
Physical properties

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

Cite this

Physical and histological comparison of hydroxyapatite, carbonate apatite, and β-tricalcium phosphate bone substitutes. / Ishikawa, Kunio; Miyamoto, Youji; Tsuchiya, Akira; Hayashi, Koichiro; Tsuru, Kanji; Ohe, Go.

In: Materials, Vol. 11, No. 10, 1993, 16.10.2018.

Research output: Contribution to journalArticle

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