Physical Frailty is Associated with Longitudinal Decline in Global Cognitive Function in Non-Demented Older Adults

A Prospective Study

S. Chen, Takanori Honda, K. Narazaki, T. Chen, Hiro Kishimoto, Y. Haeuchi, Shuzo Kumagai

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: To assess the relationship between physical frailty and subsequent decline in global cognitive function in the non-demented elderly. Design and setting: A prospective population-based study in a west Japanese suburban town, with two-year follow-up. Participants: Community-dwellers aged 65 and older without placement in long-term care, and not having a history of dementia, Parkinson’s disease and depression at baseline, who participated in the cohort of the Sasaguri Genkimon Study and underwent follow-up assessments two years later (N = 1,045). Measurements: Global cognitive function was assessed using the Montreal Cognitive Assessment (MoCA). Physical frailty was identified according to the following five components: weight loss, low grip strength, exhaustion, slow gait speed and low physical activities. Linear regression models were used to examine associations between baseline frailty status and the MoCA scores at follow-up. Logistic regression models were used to estimate the risk of cognitive decline (defined as at least two points decrease of MoCA score) according to baseline frailty status. Results: Seven hundred and eight non-demented older adults were included in the final analyses (mean age: 72.6 ± 5.5 years, male 40.3%); 5.8% were frail, and 40.8% were prefrail at baseline. One hundred and fifty nine (22.5%) participants experienced cognitive decline over two years. After adjustment for baseline MoCA scores and all confounders, being frail at baseline was significantly associated with a decline of 1.48 points (95% confidence interval [CI], -2.37 to -0.59) in MoCA scores, as compared with non-frailty. Frail persons were over two times more likely to experience cognitive decline (adjusted odds ratio 2.28; 95% CI, 1.02 to 5.08), compared to non-frail persons. Conclusion: Physical frailty is associated with longitudinal decline in global cognitive function in the non-demented older adults over a period of two years. Physically frail older community-dwellers should be closely monitored for cognitive decline that can be sensitively captured by using the MoCA.

Original languageEnglish
Pages (from-to)82-88
Number of pages7
JournalJournal of Nutrition, Health and Aging
Volume22
Issue number1
DOIs
Publication statusPublished - Jan 1 2018

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Cognition
Prospective Studies
Linear Models
Logistic Models
Confidence Intervals
Hand Strength
Long-Term Care
Parkinson Disease
Dementia
Weight Loss
Odds Ratio
Exercise
Depression
Cognitive Dysfunction
Population

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Geriatrics and Gerontology

Cite this

@article{7f0ad93b0d4242f0bd4ac5992d4dbedd,
title = "Physical Frailty is Associated with Longitudinal Decline in Global Cognitive Function in Non-Demented Older Adults: A Prospective Study",
abstract = "Objectives: To assess the relationship between physical frailty and subsequent decline in global cognitive function in the non-demented elderly. Design and setting: A prospective population-based study in a west Japanese suburban town, with two-year follow-up. Participants: Community-dwellers aged 65 and older without placement in long-term care, and not having a history of dementia, Parkinson’s disease and depression at baseline, who participated in the cohort of the Sasaguri Genkimon Study and underwent follow-up assessments two years later (N = 1,045). Measurements: Global cognitive function was assessed using the Montreal Cognitive Assessment (MoCA). Physical frailty was identified according to the following five components: weight loss, low grip strength, exhaustion, slow gait speed and low physical activities. Linear regression models were used to examine associations between baseline frailty status and the MoCA scores at follow-up. Logistic regression models were used to estimate the risk of cognitive decline (defined as at least two points decrease of MoCA score) according to baseline frailty status. Results: Seven hundred and eight non-demented older adults were included in the final analyses (mean age: 72.6 ± 5.5 years, male 40.3{\%}); 5.8{\%} were frail, and 40.8{\%} were prefrail at baseline. One hundred and fifty nine (22.5{\%}) participants experienced cognitive decline over two years. After adjustment for baseline MoCA scores and all confounders, being frail at baseline was significantly associated with a decline of 1.48 points (95{\%} confidence interval [CI], -2.37 to -0.59) in MoCA scores, as compared with non-frailty. Frail persons were over two times more likely to experience cognitive decline (adjusted odds ratio 2.28; 95{\%} CI, 1.02 to 5.08), compared to non-frail persons. Conclusion: Physical frailty is associated with longitudinal decline in global cognitive function in the non-demented older adults over a period of two years. Physically frail older community-dwellers should be closely monitored for cognitive decline that can be sensitively captured by using the MoCA.",
author = "S. Chen and Takanori Honda and K. Narazaki and T. Chen and Hiro Kishimoto and Y. Haeuchi and Shuzo Kumagai",
year = "2018",
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doi = "10.1007/s12603-017-0924-1",
language = "English",
volume = "22",
pages = "82--88",
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T1 - Physical Frailty is Associated with Longitudinal Decline in Global Cognitive Function in Non-Demented Older Adults

T2 - A Prospective Study

AU - Chen, S.

AU - Honda, Takanori

AU - Narazaki, K.

AU - Chen, T.

AU - Kishimoto, Hiro

AU - Haeuchi, Y.

AU - Kumagai, Shuzo

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Objectives: To assess the relationship between physical frailty and subsequent decline in global cognitive function in the non-demented elderly. Design and setting: A prospective population-based study in a west Japanese suburban town, with two-year follow-up. Participants: Community-dwellers aged 65 and older without placement in long-term care, and not having a history of dementia, Parkinson’s disease and depression at baseline, who participated in the cohort of the Sasaguri Genkimon Study and underwent follow-up assessments two years later (N = 1,045). Measurements: Global cognitive function was assessed using the Montreal Cognitive Assessment (MoCA). Physical frailty was identified according to the following five components: weight loss, low grip strength, exhaustion, slow gait speed and low physical activities. Linear regression models were used to examine associations between baseline frailty status and the MoCA scores at follow-up. Logistic regression models were used to estimate the risk of cognitive decline (defined as at least two points decrease of MoCA score) according to baseline frailty status. Results: Seven hundred and eight non-demented older adults were included in the final analyses (mean age: 72.6 ± 5.5 years, male 40.3%); 5.8% were frail, and 40.8% were prefrail at baseline. One hundred and fifty nine (22.5%) participants experienced cognitive decline over two years. After adjustment for baseline MoCA scores and all confounders, being frail at baseline was significantly associated with a decline of 1.48 points (95% confidence interval [CI], -2.37 to -0.59) in MoCA scores, as compared with non-frailty. Frail persons were over two times more likely to experience cognitive decline (adjusted odds ratio 2.28; 95% CI, 1.02 to 5.08), compared to non-frail persons. Conclusion: Physical frailty is associated with longitudinal decline in global cognitive function in the non-demented older adults over a period of two years. Physically frail older community-dwellers should be closely monitored for cognitive decline that can be sensitively captured by using the MoCA.

AB - Objectives: To assess the relationship between physical frailty and subsequent decline in global cognitive function in the non-demented elderly. Design and setting: A prospective population-based study in a west Japanese suburban town, with two-year follow-up. Participants: Community-dwellers aged 65 and older without placement in long-term care, and not having a history of dementia, Parkinson’s disease and depression at baseline, who participated in the cohort of the Sasaguri Genkimon Study and underwent follow-up assessments two years later (N = 1,045). Measurements: Global cognitive function was assessed using the Montreal Cognitive Assessment (MoCA). Physical frailty was identified according to the following five components: weight loss, low grip strength, exhaustion, slow gait speed and low physical activities. Linear regression models were used to examine associations between baseline frailty status and the MoCA scores at follow-up. Logistic regression models were used to estimate the risk of cognitive decline (defined as at least two points decrease of MoCA score) according to baseline frailty status. Results: Seven hundred and eight non-demented older adults were included in the final analyses (mean age: 72.6 ± 5.5 years, male 40.3%); 5.8% were frail, and 40.8% were prefrail at baseline. One hundred and fifty nine (22.5%) participants experienced cognitive decline over two years. After adjustment for baseline MoCA scores and all confounders, being frail at baseline was significantly associated with a decline of 1.48 points (95% confidence interval [CI], -2.37 to -0.59) in MoCA scores, as compared with non-frailty. Frail persons were over two times more likely to experience cognitive decline (adjusted odds ratio 2.28; 95% CI, 1.02 to 5.08), compared to non-frail persons. Conclusion: Physical frailty is associated with longitudinal decline in global cognitive function in the non-demented older adults over a period of two years. Physically frail older community-dwellers should be closely monitored for cognitive decline that can be sensitively captured by using the MoCA.

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