Physiological functions of iso-type short-chain fatty acid and omega 3 polyunsaturated fatty acids containing oil in obese OLETF rats

Bungo Shirouchi, Koji Nagao, Kenta Furuya, Toshiharu Nagai, Kenji Ichioka, Shigeru Tokairin, Yasuhiro Iida, Teruyoshi Yanagita

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

It has been known that tissues of porpoise contain unique structured-lipids as combination of iso-valeric acid (iso-C5:0) and omega 3 polyunsaturated fatty acids (ω3 PUFAs). It is well known that ω3 PU-FAs have lipid-lowering effects in animal and human studies. Although branched chain fatty acids have been interested in their unique functions, there is no data concerning the effect of iso-C5:0 on lipid metabo-lism. In this study we investigated the effect of structured-lipids from porpoise adipose tissue (porpoise oil) on lipid metabolism in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. For 4 weeks, rats were fed semisynthetic diets containing either 10% corn oil or 5% corn oil plus 5% porpoise oil. After feeding period, the porpoise oil diet significantly alleviated hepatic triglyceride accumulation compared with the control diet in OLETF rats. Although serum triglyceride level increased, serum level of adiponectin that can protect liver function and alleviate abnormalities of lipid and glucose metabolism increased in rats fed porpoise oil diet. In conclusion, results from the present study suggest that porpoise oil feeding prevents the develop-ment of fatty liver disease through the enhancement of lipoprotein secretion and increase of adiponectin production in obese rats.

Original languageEnglish
Pages (from-to)299-305
Number of pages7
JournalJournal of Oleo Science
Volume59
Issue number6
DOIs
Publication statusPublished - Jan 1 2010
Externally publishedYes

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Polyunsaturated fatty acids
Volatile Fatty Acids
Unsaturated Fatty Acids
Fatty acids
Rats
Nutrition
Oils
Lipids
Corn Oil
Adiponectin
Liver
Triglycerides
Tissue
Metabolism
Lipoproteins
Animals
Fatty Acids
Glucose
Acids

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Physiological functions of iso-type short-chain fatty acid and omega 3 polyunsaturated fatty acids containing oil in obese OLETF rats. / Shirouchi, Bungo; Nagao, Koji; Furuya, Kenta; Nagai, Toshiharu; Ichioka, Kenji; Tokairin, Shigeru; Iida, Yasuhiro; Yanagita, Teruyoshi.

In: Journal of Oleo Science, Vol. 59, No. 6, 01.01.2010, p. 299-305.

Research output: Contribution to journalArticle

Shirouchi, Bungo ; Nagao, Koji ; Furuya, Kenta ; Nagai, Toshiharu ; Ichioka, Kenji ; Tokairin, Shigeru ; Iida, Yasuhiro ; Yanagita, Teruyoshi. / Physiological functions of iso-type short-chain fatty acid and omega 3 polyunsaturated fatty acids containing oil in obese OLETF rats. In: Journal of Oleo Science. 2010 ; Vol. 59, No. 6. pp. 299-305.
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