Phytochelatins inhibit the metal-induced aggregation of α-crystallin

Yasuhisa Hori, Tomoaki Yoshikawa, Naoki Tsuji, Takeshi Bamba, Yoshikazu Aso, Motonori Kudou, Yoshiki Uchida, Masahiro Takagi, Kazuo Harada, Kazumasa Hirata

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Phytochelatins (PCs) are heavy-metal-binding peptides found in some eukaryotes. This study investigates the use of plant-derived PCs for the inhibition of metal-induced protein aggregation. The results of this study show that PCs inhibit zinc-induced α-crystallin aggregation, and suggest that PCs might be useful as anti-cataract agents.

Original languageEnglish
Pages (from-to)173-176
Number of pages4
JournalJournal of Bioscience and Bioengineering
Volume107
Issue number2
DOIs
Publication statusPublished - Feb 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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