Piceatannol inhibits mast cell-mediated allergic inflammation

Yu Jin Ko, Hui Hun Kim, Eun Jung Kim, Yoshinori Katakura, Won Sup Lee, Gon Sup Kim, Chung Ho Ryu

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Piceatannol is a phenolic stilbenoid and a metabolite of resveratrol which is found in red wine. Piceatannol (PIC) commonly exhibits anti-inflammatory, antiplatelet and antiproliferative activity. In the present study, the anti-allergic and anti-inflammatory mechanisms of PIC were investigated by examining the effects of PIC on pro inflammatory cytokine release and phosphorylation of mitogen-activated protein (MAP) kinases (ERK, JNK and p38) in a human mast cell line. PIC dose-dependently inhibited compound 48/80-induced systemic anaphylaxis and immunoglobulin E-mediated local allergic reactions. PIC reduced the immunoglobulin E (IgE)-mediated local allergic reaction and attenuated histamine release from rat peritoneal mast cells. Histamine and β-hexosaminidase release was markedly decreased dose-dependently by PIC treatment in RBL-2H3 cells. PIC treatments of HMC-1 cells definitely reduced mRNA expression and the release of the pro inflammatory cytokines, tumor necrosis factor-α and interleukin-8. MAP kinase phosphorylation was also strongly decreased dose-dependently following PIC treatment. PIC regulated the production of cytokines and histamine in phorbol 12-myristate 13-acetate plus A23187-stimulated mast cells. Thus, PIC may alleviate allergic inflammation and may be a useful therapeutic agent for allergic diseases.

Original languageEnglish
Pages (from-to)951-958
Number of pages8
JournalInternational journal of molecular medicine
Volume31
Issue number4
DOIs
Publication statusPublished - Apr 1 2013

Fingerprint

Mast Cells
Inflammation
Histamine Release
Cytokines
Immunoglobulin E
Hypersensitivity
3,3',4,5'-tetrahydroxystilbene
Anti-Inflammatory Agents
Phosphorylation
p-Methoxy-N-methylphenethylamine
Hexosaminidases
Anti-Allergic Agents
Calcimycin
Anaphylaxis
p38 Mitogen-Activated Protein Kinases
Wine
Mitogen-Activated Protein Kinases
Interleukin-8
Histamine
Acetates

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Piceatannol inhibits mast cell-mediated allergic inflammation. / Ko, Yu Jin; Kim, Hui Hun; Kim, Eun Jung; Katakura, Yoshinori; Lee, Won Sup; Kim, Gon Sup; Ryu, Chung Ho.

In: International journal of molecular medicine, Vol. 31, No. 4, 01.04.2013, p. 951-958.

Research output: Contribution to journalArticle

Ko, Yu Jin ; Kim, Hui Hun ; Kim, Eun Jung ; Katakura, Yoshinori ; Lee, Won Sup ; Kim, Gon Sup ; Ryu, Chung Ho. / Piceatannol inhibits mast cell-mediated allergic inflammation. In: International journal of molecular medicine. 2013 ; Vol. 31, No. 4. pp. 951-958.
@article{292320960b504edd90b286bbb20b5a0c,
title = "Piceatannol inhibits mast cell-mediated allergic inflammation",
abstract = "Piceatannol is a phenolic stilbenoid and a metabolite of resveratrol which is found in red wine. Piceatannol (PIC) commonly exhibits anti-inflammatory, antiplatelet and antiproliferative activity. In the present study, the anti-allergic and anti-inflammatory mechanisms of PIC were investigated by examining the effects of PIC on pro inflammatory cytokine release and phosphorylation of mitogen-activated protein (MAP) kinases (ERK, JNK and p38) in a human mast cell line. PIC dose-dependently inhibited compound 48/80-induced systemic anaphylaxis and immunoglobulin E-mediated local allergic reactions. PIC reduced the immunoglobulin E (IgE)-mediated local allergic reaction and attenuated histamine release from rat peritoneal mast cells. Histamine and β-hexosaminidase release was markedly decreased dose-dependently by PIC treatment in RBL-2H3 cells. PIC treatments of HMC-1 cells definitely reduced mRNA expression and the release of the pro inflammatory cytokines, tumor necrosis factor-α and interleukin-8. MAP kinase phosphorylation was also strongly decreased dose-dependently following PIC treatment. PIC regulated the production of cytokines and histamine in phorbol 12-myristate 13-acetate plus A23187-stimulated mast cells. Thus, PIC may alleviate allergic inflammation and may be a useful therapeutic agent for allergic diseases.",
author = "Ko, {Yu Jin} and Kim, {Hui Hun} and Kim, {Eun Jung} and Yoshinori Katakura and Lee, {Won Sup} and Kim, {Gon Sup} and Ryu, {Chung Ho}",
year = "2013",
month = "4",
day = "1",
doi = "10.3892/ijmm.2013.1283",
language = "English",
volume = "31",
pages = "951--958",
journal = "International Journal of Molecular Medicine",
issn = "1107-3756",
publisher = "Spandidos Publications",
number = "4",

}

TY - JOUR

T1 - Piceatannol inhibits mast cell-mediated allergic inflammation

AU - Ko, Yu Jin

AU - Kim, Hui Hun

AU - Kim, Eun Jung

AU - Katakura, Yoshinori

AU - Lee, Won Sup

AU - Kim, Gon Sup

AU - Ryu, Chung Ho

PY - 2013/4/1

Y1 - 2013/4/1

N2 - Piceatannol is a phenolic stilbenoid and a metabolite of resveratrol which is found in red wine. Piceatannol (PIC) commonly exhibits anti-inflammatory, antiplatelet and antiproliferative activity. In the present study, the anti-allergic and anti-inflammatory mechanisms of PIC were investigated by examining the effects of PIC on pro inflammatory cytokine release and phosphorylation of mitogen-activated protein (MAP) kinases (ERK, JNK and p38) in a human mast cell line. PIC dose-dependently inhibited compound 48/80-induced systemic anaphylaxis and immunoglobulin E-mediated local allergic reactions. PIC reduced the immunoglobulin E (IgE)-mediated local allergic reaction and attenuated histamine release from rat peritoneal mast cells. Histamine and β-hexosaminidase release was markedly decreased dose-dependently by PIC treatment in RBL-2H3 cells. PIC treatments of HMC-1 cells definitely reduced mRNA expression and the release of the pro inflammatory cytokines, tumor necrosis factor-α and interleukin-8. MAP kinase phosphorylation was also strongly decreased dose-dependently following PIC treatment. PIC regulated the production of cytokines and histamine in phorbol 12-myristate 13-acetate plus A23187-stimulated mast cells. Thus, PIC may alleviate allergic inflammation and may be a useful therapeutic agent for allergic diseases.

AB - Piceatannol is a phenolic stilbenoid and a metabolite of resveratrol which is found in red wine. Piceatannol (PIC) commonly exhibits anti-inflammatory, antiplatelet and antiproliferative activity. In the present study, the anti-allergic and anti-inflammatory mechanisms of PIC were investigated by examining the effects of PIC on pro inflammatory cytokine release and phosphorylation of mitogen-activated protein (MAP) kinases (ERK, JNK and p38) in a human mast cell line. PIC dose-dependently inhibited compound 48/80-induced systemic anaphylaxis and immunoglobulin E-mediated local allergic reactions. PIC reduced the immunoglobulin E (IgE)-mediated local allergic reaction and attenuated histamine release from rat peritoneal mast cells. Histamine and β-hexosaminidase release was markedly decreased dose-dependently by PIC treatment in RBL-2H3 cells. PIC treatments of HMC-1 cells definitely reduced mRNA expression and the release of the pro inflammatory cytokines, tumor necrosis factor-α and interleukin-8. MAP kinase phosphorylation was also strongly decreased dose-dependently following PIC treatment. PIC regulated the production of cytokines and histamine in phorbol 12-myristate 13-acetate plus A23187-stimulated mast cells. Thus, PIC may alleviate allergic inflammation and may be a useful therapeutic agent for allergic diseases.

UR - http://www.scopus.com/inward/record.url?scp=84875251054&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875251054&partnerID=8YFLogxK

U2 - 10.3892/ijmm.2013.1283

DO - 10.3892/ijmm.2013.1283

M3 - Article

VL - 31

SP - 951

EP - 958

JO - International Journal of Molecular Medicine

JF - International Journal of Molecular Medicine

SN - 1107-3756

IS - 4

ER -