'PICsome' self-assembled from a pair of oppositely charged block copolymers as containers of water-soluble macromolecules

Aya Koide, Akihiro Kishmura, Kensuke Osada, Yuichi Yamasaki, Kazunon Kataoka

Research output: Contribution to conferencePaperpeer-review

Abstract

A novel type of polymersome formed through a self-assembly of polyion complex of block copolymers was firstly designed as "PICsome". The simplicity of the process of solute encapsulation into the PICsome indicates the feasibility of the PICsome as a container for water-soluble macromolecules. The PICsome with encapsulated FITC-Dex was appreciably stable in physiological buffer as observed by confocal laser scanning microscope (CLSM) even after three months standing at ambient temperature. Furthermore, the CLSM results indicate that the PICsome membrane has a semipermeable character to allow the penetration of only small molecules.

Original languageEnglish
Pages2007
Number of pages1
Publication statusPublished - 2006
Externally publishedYes
Event55th SPSJ Annual Meeting - Nagoya, Japan
Duration: May 24 2006May 26 2006

Other

Other55th SPSJ Annual Meeting
Country/TerritoryJapan
CityNagoya
Period5/24/065/26/06

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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