Piling up clear cells in müllerian-type mucinous and mixed cell-type borderline tumor do not represent concomitant clear cell neoplasms

Yoshihiro Ohishi, Shuichi Kurihara, murasaki aman, Tadahisa Takeuchi, Hiroko Imamura, Tsunehisa Kaku, Hiroaki Kobayashi, Norio Wake, Yoshinao Oda

Research output: Contribution to journalArticle

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Abstract

The nature of piling up proliferation of clear cells in müllerian mucinous/mixed borderline tumor has not been well characterized. The purpose of this study was to clarify whether or not such clear cells represent concomitant clear cell neoplasms. First, we carefully reviewed hematoxylin and eosin slides taken from 139 ovarian tumors diagnosed as clear cell carcinoma (112 cases) and müllerian mucinous/mixed borderline tumor (27 cases) to clarify (1) the frequency of piling-up clear cells in müllerian mucinous/mixed borderline tumor and (2) the frequency of the coexistence of typical clear cell carcinoma and müllerian mucinous/mixed borderline tumor. Second, we investigated the immunohistochemical expression of estrogen receptor, hepatocyte nuclear factor-1β, and glypican-3 in proliferating clear cells in both tumors. We identified piling-up clear cells in 56% of müllerian mucinous/mixed borderline tumors. Such clear cells lacked the severe nuclear atypia, complex branching, and dense hyalinized cores of typical clear cell carcinoma. We did not find coexistence of typical clear cell carcinoma and müllerian mucinous/mixed borderline tumor in any tumors. Piling-up clear cells and endocervical-like mucinous cells were positive for estrogen receptor but negative for hepatocyte nuclear factor-1β and glypican-3. Most clear cell carcinomas showed a hepatocyte nuclear factor-1β-positive/estrogen receptor-negative immunophenotype, and about half of them were glypican-3 positive. In conclusion, piling-up clear cells in müllerian mucinous/mixed borderline tumor do not represent concomitant clear cell neoplasms because clear cell carcinoma and müllerian mucinous/mixed borderline tumor hardly ever coexist and because such clear cells in both tumors are immunophenotypically distinct.

Original languageEnglish
Pages (from-to)1618-1626
Number of pages9
JournalHuman Pathology
Volume43
Issue number10
DOIs
Publication statusPublished - Oct 1 2012

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Neoplasms
Hepatocyte Nuclear Factor 1
Glypicans
Mucinous Adenocarcinoma
Estrogen Receptors
Carcinoma
Hematoxylin
Eosine Yellowish-(YS)
Cell Proliferation

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Piling up clear cells in müllerian-type mucinous and mixed cell-type borderline tumor do not represent concomitant clear cell neoplasms. / Ohishi, Yoshihiro; Kurihara, Shuichi; aman, murasaki; Takeuchi, Tadahisa; Imamura, Hiroko; Kaku, Tsunehisa; Kobayashi, Hiroaki; Wake, Norio; Oda, Yoshinao.

In: Human Pathology, Vol. 43, No. 10, 01.10.2012, p. 1618-1626.

Research output: Contribution to journalArticle

Ohishi, Yoshihiro ; Kurihara, Shuichi ; aman, murasaki ; Takeuchi, Tadahisa ; Imamura, Hiroko ; Kaku, Tsunehisa ; Kobayashi, Hiroaki ; Wake, Norio ; Oda, Yoshinao. / Piling up clear cells in müllerian-type mucinous and mixed cell-type borderline tumor do not represent concomitant clear cell neoplasms. In: Human Pathology. 2012 ; Vol. 43, No. 10. pp. 1618-1626.
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abstract = "The nature of piling up proliferation of clear cells in m{\"u}llerian mucinous/mixed borderline tumor has not been well characterized. The purpose of this study was to clarify whether or not such clear cells represent concomitant clear cell neoplasms. First, we carefully reviewed hematoxylin and eosin slides taken from 139 ovarian tumors diagnosed as clear cell carcinoma (112 cases) and m{\"u}llerian mucinous/mixed borderline tumor (27 cases) to clarify (1) the frequency of piling-up clear cells in m{\"u}llerian mucinous/mixed borderline tumor and (2) the frequency of the coexistence of typical clear cell carcinoma and m{\"u}llerian mucinous/mixed borderline tumor. Second, we investigated the immunohistochemical expression of estrogen receptor, hepatocyte nuclear factor-1β, and glypican-3 in proliferating clear cells in both tumors. We identified piling-up clear cells in 56{\%} of m{\"u}llerian mucinous/mixed borderline tumors. Such clear cells lacked the severe nuclear atypia, complex branching, and dense hyalinized cores of typical clear cell carcinoma. We did not find coexistence of typical clear cell carcinoma and m{\"u}llerian mucinous/mixed borderline tumor in any tumors. Piling-up clear cells and endocervical-like mucinous cells were positive for estrogen receptor but negative for hepatocyte nuclear factor-1β and glypican-3. Most clear cell carcinomas showed a hepatocyte nuclear factor-1β-positive/estrogen receptor-negative immunophenotype, and about half of them were glypican-3 positive. In conclusion, piling-up clear cells in m{\"u}llerian mucinous/mixed borderline tumor do not represent concomitant clear cell neoplasms because clear cell carcinoma and m{\"u}llerian mucinous/mixed borderline tumor hardly ever coexist and because such clear cells in both tumors are immunophenotypically distinct.",
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