Pinacidil inhibits the ryanodine‐sensitive outward current and glibenclamide antagonizes its action in cells from the rabbit portal vein

Zhiling Xiong, Shunichi Kajioka, Takeshi Sakai, Kenji Kitamura, Hirosi Kuriyama

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Pinacidil, a potassium‐channel opener, inhibited the ryanodine‐sensitive oscillatory outward potassium current induced by Ca released from an intracellular store. Glibenclamide, a blocker of the ATP‐sensitive K‐channel, prevented the action of pinacidil, suggesting the presence of an additional site (to K channels) for the vasodilator actions of pinacidil at which glibenclamide can act as an antagonist. 1991 British Pharmacological Society

Original languageEnglish
Pages (from-to)788-790
Number of pages3
JournalBritish Journal of Pharmacology
Volume102
Issue number4
DOIs
Publication statusPublished - Apr 1991

All Science Journal Classification (ASJC) codes

  • Pharmacology

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