Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion

Taito Matsuda, Takashi Irie, Shutaro Katsurabayashi, Yoshinori Hayashi, Tatsuya Nagai, Nobuhiko Hamazaki, Aliya Mari D. Adefuin, Fumihito Miura, Takashi Ito, Hiroshi Kimura, Katsuhiko Shirahige, Tadayuki Takeda, Katsunori Iwasaki, Takuya Imamura, Kinichi Nakashima

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Matsuda et al. report direct neuronal conversion of microglia induced by the expression of a single transcription factor, NeuroD1, which occupies bivalent epigenetic domains for neuronal gene induction. NeuroD1 can also converts microglia into neurons in the adult mouse striatum.

Original languageEnglish
Pages (from-to)472-485.e7
JournalNeuron
Volume101
Issue number3
DOIs
Publication statusPublished - Feb 6 2019

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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