Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion

Taito Matsuda, Takashi Irie, Shutaro Katsurabayashi, Yoshinori Hayashi, Tatsuya Nagai, Nobuhiko Hamazaki, Aliya Mari D. Adefuin, Fumihito Miura, Takashi Ito, Hiroshi Kimura, Katsuhiko Shirahige, Tadayuki Takeda, Katsunori Iwasaki, Takuya Imamura, Kinichi Nakashima

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Matsuda et al. report direct neuronal conversion of microglia induced by the expression of a single transcription factor, NeuroD1, which occupies bivalent epigenetic domains for neuronal gene induction. NeuroD1 can also converts microglia into neurons in the adult mouse striatum.

Original languageEnglish
Pages (from-to)472-485.e7
JournalNeuron
Volume101
Issue number3
DOIs
Publication statusPublished - Feb 6 2019

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Microglia
Epigenomics
Neurons
Transcription Factors
Genes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion. / Matsuda, Taito; Irie, Takashi; Katsurabayashi, Shutaro; Hayashi, Yoshinori; Nagai, Tatsuya; Hamazaki, Nobuhiko; Adefuin, Aliya Mari D.; Miura, Fumihito; Ito, Takashi; Kimura, Hiroshi; Shirahige, Katsuhiko; Takeda, Tadayuki; Iwasaki, Katsunori; Imamura, Takuya; Nakashima, Kinichi.

In: Neuron, Vol. 101, No. 3, 06.02.2019, p. 472-485.e7.

Research output: Contribution to journalArticle

Matsuda, T, Irie, T, Katsurabayashi, S, Hayashi, Y, Nagai, T, Hamazaki, N, Adefuin, AMD, Miura, F, Ito, T, Kimura, H, Shirahige, K, Takeda, T, Iwasaki, K, Imamura, T & Nakashima, K 2019, 'Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion', Neuron, vol. 101, no. 3, pp. 472-485.e7. https://doi.org/10.1016/j.neuron.2018.12.010
Matsuda, Taito ; Irie, Takashi ; Katsurabayashi, Shutaro ; Hayashi, Yoshinori ; Nagai, Tatsuya ; Hamazaki, Nobuhiko ; Adefuin, Aliya Mari D. ; Miura, Fumihito ; Ito, Takashi ; Kimura, Hiroshi ; Shirahige, Katsuhiko ; Takeda, Tadayuki ; Iwasaki, Katsunori ; Imamura, Takuya ; Nakashima, Kinichi. / Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion. In: Neuron. 2019 ; Vol. 101, No. 3. pp. 472-485.e7.
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