Plasma Adrenal Androgens in Adult Diabetic Men

Naoki Nakashima, Takashi Sugimura, Yasuhiro Ono, Taito Esaki, Toshihiko Yanase, Fumio Umeda, Hajlme Nawata, Masaharu Motomura

Research output: Contribution to journalArticle

Abstract

The adrenal androgens dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEA-S) reportedly have anti-diabetic and anti-atherosclerotic effects. We investigated the concentrations of plasma adrenal androgens and other steroid hormones in diabetic subjects. In 59 adult diabetic men not receiving insulin therapy who were outpatients at our hospital and 32 healthy controls, we estimated the fasting plasma concentrations of DHEA, DHEA-S, testosterone, estradiol, cortisol, blood glucose (FBG), HbA1C, and immunoreactive insulin (IRI). After 6 months of glycemic control, we again measured the same parameters in 28 of the diabetic patients. In all participants, DHEA-S showed significant negative correlations with FBG (r=-0.24) and HbA1C (r=-0.25). Plasma DHEA concentrations in relative hyperinsulinemic patients (IRI≧10μU/ml, n=25) were significantly lower than those in a normoinsulinemic patients (IRK10μU/ml, n = 66 ; 1.91 ±1.32 ng/ml, mean±SD, vs. 2.42± 1.12 ng/ml, p<0.01, respectively). After the glycemic control, plasma DHEA-S concentrations increased significantly (p<0.05) in the patients with improved HbA1C levels (ΔHbA1C≧1%, n = 6). Plasma DHEA concentrations increased significantly (p<0.05) in the patients with decreased IRI levels (n = 12). The present results indicate that in adult diabetic men, parameters reflecting a state of diabetic control are related to plasma DHEA-S concentrations, while plasma IRI levels are related to plasma DHEA concentrations.

Original languageEnglish
Pages (from-to)521-529
Number of pages9
JournalJournal of the Japan Diabetes Society
Volume40
Issue number8
DOIs
Publication statusPublished - Jan 1 1997
Externally publishedYes

Fingerprint

Dehydroepiandrosterone
Androgens
Insulin
Dehydroepiandrosterone Sulfate
Hydrocortisone
Blood Glucose
Testosterone
Estradiol
Fasting
Outpatients
Steroids
Hormones

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Nakashima, N., Sugimura, T., Ono, Y., Esaki, T., Yanase, T., Umeda, F., ... Motomura, M. (1997). Plasma Adrenal Androgens in Adult Diabetic Men. Journal of the Japan Diabetes Society, 40(8), 521-529. https://doi.org/10.11213/tonyobyo1958.40.521

Plasma Adrenal Androgens in Adult Diabetic Men. / Nakashima, Naoki; Sugimura, Takashi; Ono, Yasuhiro; Esaki, Taito; Yanase, Toshihiko; Umeda, Fumio; Nawata, Hajlme; Motomura, Masaharu.

In: Journal of the Japan Diabetes Society, Vol. 40, No. 8, 01.01.1997, p. 521-529.

Research output: Contribution to journalArticle

Nakashima, N, Sugimura, T, Ono, Y, Esaki, T, Yanase, T, Umeda, F, Nawata, H & Motomura, M 1997, 'Plasma Adrenal Androgens in Adult Diabetic Men', Journal of the Japan Diabetes Society, vol. 40, no. 8, pp. 521-529. https://doi.org/10.11213/tonyobyo1958.40.521
Nakashima, Naoki ; Sugimura, Takashi ; Ono, Yasuhiro ; Esaki, Taito ; Yanase, Toshihiko ; Umeda, Fumio ; Nawata, Hajlme ; Motomura, Masaharu. / Plasma Adrenal Androgens in Adult Diabetic Men. In: Journal of the Japan Diabetes Society. 1997 ; Vol. 40, No. 8. pp. 521-529.
@article{68eb4f2fe26e4dafab1fdabffd7b9211,
title = "Plasma Adrenal Androgens in Adult Diabetic Men",
abstract = "The adrenal androgens dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEA-S) reportedly have anti-diabetic and anti-atherosclerotic effects. We investigated the concentrations of plasma adrenal androgens and other steroid hormones in diabetic subjects. In 59 adult diabetic men not receiving insulin therapy who were outpatients at our hospital and 32 healthy controls, we estimated the fasting plasma concentrations of DHEA, DHEA-S, testosterone, estradiol, cortisol, blood glucose (FBG), HbA1C, and immunoreactive insulin (IRI). After 6 months of glycemic control, we again measured the same parameters in 28 of the diabetic patients. In all participants, DHEA-S showed significant negative correlations with FBG (r=-0.24) and HbA1C (r=-0.25). Plasma DHEA concentrations in relative hyperinsulinemic patients (IRI≧10μU/ml, n=25) were significantly lower than those in a normoinsulinemic patients (IRK10μU/ml, n = 66 ; 1.91 ±1.32 ng/ml, mean±SD, vs. 2.42± 1.12 ng/ml, p<0.01, respectively). After the glycemic control, plasma DHEA-S concentrations increased significantly (p<0.05) in the patients with improved HbA1C levels (ΔHbA1C≧1{\%}, n = 6). Plasma DHEA concentrations increased significantly (p<0.05) in the patients with decreased IRI levels (n = 12). The present results indicate that in adult diabetic men, parameters reflecting a state of diabetic control are related to plasma DHEA-S concentrations, while plasma IRI levels are related to plasma DHEA concentrations.",
author = "Naoki Nakashima and Takashi Sugimura and Yasuhiro Ono and Taito Esaki and Toshihiko Yanase and Fumio Umeda and Hajlme Nawata and Masaharu Motomura",
year = "1997",
month = "1",
day = "1",
doi = "10.11213/tonyobyo1958.40.521",
language = "English",
volume = "40",
pages = "521--529",
journal = "Journal of the Japan Diabetes Society",
issn = "0021-437X",
publisher = "Japan Diabetes Society",
number = "8",

}

TY - JOUR

T1 - Plasma Adrenal Androgens in Adult Diabetic Men

AU - Nakashima, Naoki

AU - Sugimura, Takashi

AU - Ono, Yasuhiro

AU - Esaki, Taito

AU - Yanase, Toshihiko

AU - Umeda, Fumio

AU - Nawata, Hajlme

AU - Motomura, Masaharu

PY - 1997/1/1

Y1 - 1997/1/1

N2 - The adrenal androgens dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEA-S) reportedly have anti-diabetic and anti-atherosclerotic effects. We investigated the concentrations of plasma adrenal androgens and other steroid hormones in diabetic subjects. In 59 adult diabetic men not receiving insulin therapy who were outpatients at our hospital and 32 healthy controls, we estimated the fasting plasma concentrations of DHEA, DHEA-S, testosterone, estradiol, cortisol, blood glucose (FBG), HbA1C, and immunoreactive insulin (IRI). After 6 months of glycemic control, we again measured the same parameters in 28 of the diabetic patients. In all participants, DHEA-S showed significant negative correlations with FBG (r=-0.24) and HbA1C (r=-0.25). Plasma DHEA concentrations in relative hyperinsulinemic patients (IRI≧10μU/ml, n=25) were significantly lower than those in a normoinsulinemic patients (IRK10μU/ml, n = 66 ; 1.91 ±1.32 ng/ml, mean±SD, vs. 2.42± 1.12 ng/ml, p<0.01, respectively). After the glycemic control, plasma DHEA-S concentrations increased significantly (p<0.05) in the patients with improved HbA1C levels (ΔHbA1C≧1%, n = 6). Plasma DHEA concentrations increased significantly (p<0.05) in the patients with decreased IRI levels (n = 12). The present results indicate that in adult diabetic men, parameters reflecting a state of diabetic control are related to plasma DHEA-S concentrations, while plasma IRI levels are related to plasma DHEA concentrations.

AB - The adrenal androgens dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEA-S) reportedly have anti-diabetic and anti-atherosclerotic effects. We investigated the concentrations of plasma adrenal androgens and other steroid hormones in diabetic subjects. In 59 adult diabetic men not receiving insulin therapy who were outpatients at our hospital and 32 healthy controls, we estimated the fasting plasma concentrations of DHEA, DHEA-S, testosterone, estradiol, cortisol, blood glucose (FBG), HbA1C, and immunoreactive insulin (IRI). After 6 months of glycemic control, we again measured the same parameters in 28 of the diabetic patients. In all participants, DHEA-S showed significant negative correlations with FBG (r=-0.24) and HbA1C (r=-0.25). Plasma DHEA concentrations in relative hyperinsulinemic patients (IRI≧10μU/ml, n=25) were significantly lower than those in a normoinsulinemic patients (IRK10μU/ml, n = 66 ; 1.91 ±1.32 ng/ml, mean±SD, vs. 2.42± 1.12 ng/ml, p<0.01, respectively). After the glycemic control, plasma DHEA-S concentrations increased significantly (p<0.05) in the patients with improved HbA1C levels (ΔHbA1C≧1%, n = 6). Plasma DHEA concentrations increased significantly (p<0.05) in the patients with decreased IRI levels (n = 12). The present results indicate that in adult diabetic men, parameters reflecting a state of diabetic control are related to plasma DHEA-S concentrations, while plasma IRI levels are related to plasma DHEA concentrations.

UR - http://www.scopus.com/inward/record.url?scp=85024733568&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85024733568&partnerID=8YFLogxK

U2 - 10.11213/tonyobyo1958.40.521

DO - 10.11213/tonyobyo1958.40.521

M3 - Article

AN - SCOPUS:85024733568

VL - 40

SP - 521

EP - 529

JO - Journal of the Japan Diabetes Society

JF - Journal of the Japan Diabetes Society

SN - 0021-437X

IS - 8

ER -