Abstract
The plasma concentrations of angiotensin (Ang) I, Ang II, and their metabolites (Ang (3-8), (4-8), (5-8), and (3-4)) following in vitro ACE inhibitory activity were examined in young male normotensive (NT) (n = 7), and mild hypertensive (HT) volunteers in = 6). There were no differences in supine plasma levels of Ang I, Ang II, and Ang (5-8) between the NT and HT groups: Ang I, 304 ± 43 fmol/ml vs. 293 ± 15 fmol/ml; Ang II, 32 ± 6 fmol/ml vs. 43 ± 10 fmol/ml; Ang (5-8), 176 ± 22 fmol/ml vs. 133 ± 32 fmol/ml. In addition, there were no significant differences between groups in any of these Ang levels when measured after standing for 60 min. However, the HT group showed significantly reduced supine and upright plasma Ang (3-8) and Ang (3-4) levels as compared to the NT group. In particular, the supine plasma level of Ang (3-4) (71 ± 13 fmol/ml-plasma) in the HT group was significantly (1/3-fold) lower than that in the NT group (197 ± 35 fmol/ml-plasma). An inverse correlation between the plasma level of Ang (3-4) and the upright systolic blood pressure (r = -0.627, p < 0.02, n = 13) was observed, indicating that the metabolism of Ang (3-4) might have been associated with the change in blood pressure.
| Original language | English |
|---|---|
| Pages (from-to) | 273-277 |
| Number of pages | 5 |
| Journal | Hypertension Research - Clinical and Experimental |
| Volume | 22 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jan 1 1999 |
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All Science Journal Classification (ASJC) codes
- Internal Medicine
- Physiology
- Cardiology and Cardiovascular Medicine
Cite this
Plasma concentrations of angiotensin metabolites in young male normotensive and mild hypertensive subjects. / Matsui, Toshiro; Tamaya, Kei; Matsumoto, Kiyoshi; Osajima, Yutaka; Uezono, Keiko; Kawasaki, Terukazu.
In: Hypertension Research - Clinical and Experimental, Vol. 22, No. 4, 01.01.1999, p. 273-277.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Plasma concentrations of angiotensin metabolites in young male normotensive and mild hypertensive subjects
AU - Matsui, Toshiro
AU - Tamaya, Kei
AU - Matsumoto, Kiyoshi
AU - Osajima, Yutaka
AU - Uezono, Keiko
AU - Kawasaki, Terukazu
PY - 1999/1/1
Y1 - 1999/1/1
N2 - The plasma concentrations of angiotensin (Ang) I, Ang II, and their metabolites (Ang (3-8), (4-8), (5-8), and (3-4)) following in vitro ACE inhibitory activity were examined in young male normotensive (NT) (n = 7), and mild hypertensive (HT) volunteers in = 6). There were no differences in supine plasma levels of Ang I, Ang II, and Ang (5-8) between the NT and HT groups: Ang I, 304 ± 43 fmol/ml vs. 293 ± 15 fmol/ml; Ang II, 32 ± 6 fmol/ml vs. 43 ± 10 fmol/ml; Ang (5-8), 176 ± 22 fmol/ml vs. 133 ± 32 fmol/ml. In addition, there were no significant differences between groups in any of these Ang levels when measured after standing for 60 min. However, the HT group showed significantly reduced supine and upright plasma Ang (3-8) and Ang (3-4) levels as compared to the NT group. In particular, the supine plasma level of Ang (3-4) (71 ± 13 fmol/ml-plasma) in the HT group was significantly (1/3-fold) lower than that in the NT group (197 ± 35 fmol/ml-plasma). An inverse correlation between the plasma level of Ang (3-4) and the upright systolic blood pressure (r = -0.627, p < 0.02, n = 13) was observed, indicating that the metabolism of Ang (3-4) might have been associated with the change in blood pressure.
AB - The plasma concentrations of angiotensin (Ang) I, Ang II, and their metabolites (Ang (3-8), (4-8), (5-8), and (3-4)) following in vitro ACE inhibitory activity were examined in young male normotensive (NT) (n = 7), and mild hypertensive (HT) volunteers in = 6). There were no differences in supine plasma levels of Ang I, Ang II, and Ang (5-8) between the NT and HT groups: Ang I, 304 ± 43 fmol/ml vs. 293 ± 15 fmol/ml; Ang II, 32 ± 6 fmol/ml vs. 43 ± 10 fmol/ml; Ang (5-8), 176 ± 22 fmol/ml vs. 133 ± 32 fmol/ml. In addition, there were no significant differences between groups in any of these Ang levels when measured after standing for 60 min. However, the HT group showed significantly reduced supine and upright plasma Ang (3-8) and Ang (3-4) levels as compared to the NT group. In particular, the supine plasma level of Ang (3-4) (71 ± 13 fmol/ml-plasma) in the HT group was significantly (1/3-fold) lower than that in the NT group (197 ± 35 fmol/ml-plasma). An inverse correlation between the plasma level of Ang (3-4) and the upright systolic blood pressure (r = -0.627, p < 0.02, n = 13) was observed, indicating that the metabolism of Ang (3-4) might have been associated with the change in blood pressure.
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U2 - 10.1291/hypres.22.273
DO - 10.1291/hypres.22.273
M3 - Article
C2 - 10580393
AN - SCOPUS:0032696884
VL - 22
SP - 273
EP - 277
JO - Hypertension Research
JF - Hypertension Research
SN - 0916-9636
IS - 4
ER -