Plasma concentrations of antipsychotic drugs in psychiatric inpatients

H. Tokunaga, K. Kudo, T. Imamura, N. Jitsufuchi, Y. Ohtsuka, N. Ikeda

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

In current psychiatric therapy, two or more kinds of antipsychotic drugs are usually prescribed in Japan. However, there are few data on the therapeutic plasma concentrations of antipsychotic drugs or on the correlation between the daily dose and the plasma concentration, in cases where several antipsychotic drugs had been prescribed for each patient. We measured the therapeutic plasma concentrations of 9 antipsychotic drugs in 24 psychiatric inpatients during a 6-month period. They were treated with fixed dosages of antipsychotic drugs. Plasma samples were collected early in the morning once a month, and the concentrations of antipsychotic drugs were determined by gas chromatography with nitrogen phosphorus detection, high- performance liquid chromatography (HPLC) with fluorescence detection and HPLC with UV detection. The plasma levels of chlorpromazine, levomepromazine, thioridazine, haloperidol, bromperidol, zotepine, oxypertine, sulpiride and sultopride were 21.8-92.4, 31.7-156, 101-203, 16.4-56.2, 2.72-11.7, 13.6- 84.0, 29.9-80.4, 70.1-1,120 and 35.7-2,990 ng/ml, respectively. A linear correlation between the daily dose and the plasma concentration was noted for sultopride, levomepromazine, sulpiride, haloperidol, chlorpromazine and zotepine.

Original languageEnglish
Pages (from-to)417-422
Number of pages6
JournalJapanese Journal of Legal Medicine
Volume51
Issue number6
Publication statusPublished - Dec 1 1997

Fingerprint

Antipsychotic Agents
Psychiatry
Inpatients
Methotrimeprazine
Sulpiride
Chlorpromazine
Haloperidol
High Pressure Liquid Chromatography
Thioridazine
Gas Chromatography
Phosphorus
Japan
Nitrogen
Therapeutics
Fluorescence
sultopride
zotepine

All Science Journal Classification (ASJC) codes

  • Health Policy
  • Law

Cite this

Tokunaga, H., Kudo, K., Imamura, T., Jitsufuchi, N., Ohtsuka, Y., & Ikeda, N. (1997). Plasma concentrations of antipsychotic drugs in psychiatric inpatients. Japanese Journal of Legal Medicine, 51(6), 417-422.

Plasma concentrations of antipsychotic drugs in psychiatric inpatients. / Tokunaga, H.; Kudo, K.; Imamura, T.; Jitsufuchi, N.; Ohtsuka, Y.; Ikeda, N.

In: Japanese Journal of Legal Medicine, Vol. 51, No. 6, 01.12.1997, p. 417-422.

Research output: Contribution to journalArticle

Tokunaga, H, Kudo, K, Imamura, T, Jitsufuchi, N, Ohtsuka, Y & Ikeda, N 1997, 'Plasma concentrations of antipsychotic drugs in psychiatric inpatients', Japanese Journal of Legal Medicine, vol. 51, no. 6, pp. 417-422.
Tokunaga H, Kudo K, Imamura T, Jitsufuchi N, Ohtsuka Y, Ikeda N. Plasma concentrations of antipsychotic drugs in psychiatric inpatients. Japanese Journal of Legal Medicine. 1997 Dec 1;51(6):417-422.
Tokunaga, H. ; Kudo, K. ; Imamura, T. ; Jitsufuchi, N. ; Ohtsuka, Y. ; Ikeda, N. / Plasma concentrations of antipsychotic drugs in psychiatric inpatients. In: Japanese Journal of Legal Medicine. 1997 ; Vol. 51, No. 6. pp. 417-422.
@article{5570b467b56546f6b6f19c91a163f440,
title = "Plasma concentrations of antipsychotic drugs in psychiatric inpatients",
abstract = "In current psychiatric therapy, two or more kinds of antipsychotic drugs are usually prescribed in Japan. However, there are few data on the therapeutic plasma concentrations of antipsychotic drugs or on the correlation between the daily dose and the plasma concentration, in cases where several antipsychotic drugs had been prescribed for each patient. We measured the therapeutic plasma concentrations of 9 antipsychotic drugs in 24 psychiatric inpatients during a 6-month period. They were treated with fixed dosages of antipsychotic drugs. Plasma samples were collected early in the morning once a month, and the concentrations of antipsychotic drugs were determined by gas chromatography with nitrogen phosphorus detection, high- performance liquid chromatography (HPLC) with fluorescence detection and HPLC with UV detection. The plasma levels of chlorpromazine, levomepromazine, thioridazine, haloperidol, bromperidol, zotepine, oxypertine, sulpiride and sultopride were 21.8-92.4, 31.7-156, 101-203, 16.4-56.2, 2.72-11.7, 13.6- 84.0, 29.9-80.4, 70.1-1,120 and 35.7-2,990 ng/ml, respectively. A linear correlation between the daily dose and the plasma concentration was noted for sultopride, levomepromazine, sulpiride, haloperidol, chlorpromazine and zotepine.",
author = "H. Tokunaga and K. Kudo and T. Imamura and N. Jitsufuchi and Y. Ohtsuka and N. Ikeda",
year = "1997",
month = "12",
day = "1",
language = "English",
volume = "51",
pages = "417--422",
journal = "Japanese Journal of Legal Medicine",
issn = "0047-1887",
publisher = "Medico-Legal Society of Japan",
number = "6",

}

TY - JOUR

T1 - Plasma concentrations of antipsychotic drugs in psychiatric inpatients

AU - Tokunaga, H.

AU - Kudo, K.

AU - Imamura, T.

AU - Jitsufuchi, N.

AU - Ohtsuka, Y.

AU - Ikeda, N.

PY - 1997/12/1

Y1 - 1997/12/1

N2 - In current psychiatric therapy, two or more kinds of antipsychotic drugs are usually prescribed in Japan. However, there are few data on the therapeutic plasma concentrations of antipsychotic drugs or on the correlation between the daily dose and the plasma concentration, in cases where several antipsychotic drugs had been prescribed for each patient. We measured the therapeutic plasma concentrations of 9 antipsychotic drugs in 24 psychiatric inpatients during a 6-month period. They were treated with fixed dosages of antipsychotic drugs. Plasma samples were collected early in the morning once a month, and the concentrations of antipsychotic drugs were determined by gas chromatography with nitrogen phosphorus detection, high- performance liquid chromatography (HPLC) with fluorescence detection and HPLC with UV detection. The plasma levels of chlorpromazine, levomepromazine, thioridazine, haloperidol, bromperidol, zotepine, oxypertine, sulpiride and sultopride were 21.8-92.4, 31.7-156, 101-203, 16.4-56.2, 2.72-11.7, 13.6- 84.0, 29.9-80.4, 70.1-1,120 and 35.7-2,990 ng/ml, respectively. A linear correlation between the daily dose and the plasma concentration was noted for sultopride, levomepromazine, sulpiride, haloperidol, chlorpromazine and zotepine.

AB - In current psychiatric therapy, two or more kinds of antipsychotic drugs are usually prescribed in Japan. However, there are few data on the therapeutic plasma concentrations of antipsychotic drugs or on the correlation between the daily dose and the plasma concentration, in cases where several antipsychotic drugs had been prescribed for each patient. We measured the therapeutic plasma concentrations of 9 antipsychotic drugs in 24 psychiatric inpatients during a 6-month period. They were treated with fixed dosages of antipsychotic drugs. Plasma samples were collected early in the morning once a month, and the concentrations of antipsychotic drugs were determined by gas chromatography with nitrogen phosphorus detection, high- performance liquid chromatography (HPLC) with fluorescence detection and HPLC with UV detection. The plasma levels of chlorpromazine, levomepromazine, thioridazine, haloperidol, bromperidol, zotepine, oxypertine, sulpiride and sultopride were 21.8-92.4, 31.7-156, 101-203, 16.4-56.2, 2.72-11.7, 13.6- 84.0, 29.9-80.4, 70.1-1,120 and 35.7-2,990 ng/ml, respectively. A linear correlation between the daily dose and the plasma concentration was noted for sultopride, levomepromazine, sulpiride, haloperidol, chlorpromazine and zotepine.

UR - http://www.scopus.com/inward/record.url?scp=0031423327&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031423327&partnerID=8YFLogxK

M3 - Article

C2 - 9545754

AN - SCOPUS:0031423327

VL - 51

SP - 417

EP - 422

JO - Japanese Journal of Legal Medicine

JF - Japanese Journal of Legal Medicine

SN - 0047-1887

IS - 6

ER -