Plasma d-dimer level as a mortality predictor in patients with advanced or recurrent colorectal cancer

Manabu Yamamoto, Keiji Yoshinaga, Ayumi Matsuyama, Tokiomi Iwasa, Atsushi Osoegawa, Eiji Tsujita, Yoichi Yamashita, Shinichi Tsutsui, Teruyoshi Ishida

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Abstract

Objective: Plasma D-dimer levels are elevated in patients with a variety of solid tumors. Recently, it has been reported that the level before curative surgery is a prognostic factor for colorectal cancer (CRC). We investigated whether the plasma D-dimer level before systemic chemotherapies is a predictor for advanced or recurrent unresectable CRC. Methods: This study included 42 patients treated with systemic chemotherapies for advanced or recurrent unresectable CRC. Variables including clinicopathological factors, plasma D-dimer levels and the modified Glasgow Prognostic Factor Score (mGPS) were evaluated. Results: The plasma D-dimer level was closely related to the mGPS. Survival was shorter for patients with plasma D-dimer levels >5 μg/ml than for those with lower levels. Compared with an mGPS of 0 or 1, an mGPS of 2 was predictive of poor prognosis (p < 0.0001). Old age, advanced stage, plasma D-dimer level and mGPS were significantly associated with mortality, but plasma D-dimer level was the only independent risk factor in multivariate analysis, and was significant related to the clinical response to chemotherapy (p < 0.05). Conclusions: Survival was significantly shorter in patients with elevated plasma D-dimer levels having advanced or recurrent CRC. The plasma D-dimer level before systemic chemotherapies was an independent mortality predictor.

Original languageEnglish
Pages (from-to)10-15
Number of pages6
JournalOncology (Switzerland)
Volume83
Issue number1
DOIs
Publication statusPublished - Jul 1 2012
Externally publishedYes

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Colorectal Neoplasms
Mortality
Drug Therapy
fibrin fragment D
Survival
Multivariate Analysis
Neoplasms

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

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Plasma d-dimer level as a mortality predictor in patients with advanced or recurrent colorectal cancer. / Yamamoto, Manabu; Yoshinaga, Keiji; Matsuyama, Ayumi; Iwasa, Tokiomi; Osoegawa, Atsushi; Tsujita, Eiji; Yamashita, Yoichi; Tsutsui, Shinichi; Ishida, Teruyoshi.

In: Oncology (Switzerland), Vol. 83, No. 1, 01.07.2012, p. 10-15.

Research output: Contribution to journalArticle

Yamamoto, M, Yoshinaga, K, Matsuyama, A, Iwasa, T, Osoegawa, A, Tsujita, E, Yamashita, Y, Tsutsui, S & Ishida, T 2012, 'Plasma d-dimer level as a mortality predictor in patients with advanced or recurrent colorectal cancer', Oncology (Switzerland), vol. 83, no. 1, pp. 10-15. https://doi.org/10.1159/000338329
Yamamoto, Manabu ; Yoshinaga, Keiji ; Matsuyama, Ayumi ; Iwasa, Tokiomi ; Osoegawa, Atsushi ; Tsujita, Eiji ; Yamashita, Yoichi ; Tsutsui, Shinichi ; Ishida, Teruyoshi. / Plasma d-dimer level as a mortality predictor in patients with advanced or recurrent colorectal cancer. In: Oncology (Switzerland). 2012 ; Vol. 83, No. 1. pp. 10-15.
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AU - Osoegawa, Atsushi

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N2 - Objective: Plasma D-dimer levels are elevated in patients with a variety of solid tumors. Recently, it has been reported that the level before curative surgery is a prognostic factor for colorectal cancer (CRC). We investigated whether the plasma D-dimer level before systemic chemotherapies is a predictor for advanced or recurrent unresectable CRC. Methods: This study included 42 patients treated with systemic chemotherapies for advanced or recurrent unresectable CRC. Variables including clinicopathological factors, plasma D-dimer levels and the modified Glasgow Prognostic Factor Score (mGPS) were evaluated. Results: The plasma D-dimer level was closely related to the mGPS. Survival was shorter for patients with plasma D-dimer levels >5 μg/ml than for those with lower levels. Compared with an mGPS of 0 or 1, an mGPS of 2 was predictive of poor prognosis (p < 0.0001). Old age, advanced stage, plasma D-dimer level and mGPS were significantly associated with mortality, but plasma D-dimer level was the only independent risk factor in multivariate analysis, and was significant related to the clinical response to chemotherapy (p < 0.05). Conclusions: Survival was significantly shorter in patients with elevated plasma D-dimer levels having advanced or recurrent CRC. The plasma D-dimer level before systemic chemotherapies was an independent mortality predictor.

AB - Objective: Plasma D-dimer levels are elevated in patients with a variety of solid tumors. Recently, it has been reported that the level before curative surgery is a prognostic factor for colorectal cancer (CRC). We investigated whether the plasma D-dimer level before systemic chemotherapies is a predictor for advanced or recurrent unresectable CRC. Methods: This study included 42 patients treated with systemic chemotherapies for advanced or recurrent unresectable CRC. Variables including clinicopathological factors, plasma D-dimer levels and the modified Glasgow Prognostic Factor Score (mGPS) were evaluated. Results: The plasma D-dimer level was closely related to the mGPS. Survival was shorter for patients with plasma D-dimer levels >5 μg/ml than for those with lower levels. Compared with an mGPS of 0 or 1, an mGPS of 2 was predictive of poor prognosis (p < 0.0001). Old age, advanced stage, plasma D-dimer level and mGPS were significantly associated with mortality, but plasma D-dimer level was the only independent risk factor in multivariate analysis, and was significant related to the clinical response to chemotherapy (p < 0.05). Conclusions: Survival was significantly shorter in patients with elevated plasma D-dimer levels having advanced or recurrent CRC. The plasma D-dimer level before systemic chemotherapies was an independent mortality predictor.

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