Plasma d-dimer level as a mortality predictor in patients with advanced or recurrent colorectal cancer

Manabu Yamamoto, Keiji Yoshinaga, Ayumi Matsuyama, Tokiomi Iwasa, Atsushi Osoegawa, Eiji Tsujita, Yoichi Yamashita, Shinichi Tsutsui, Teruyoshi Ishida

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42 Citations (Scopus)

Abstract

Objective: Plasma D-dimer levels are elevated in patients with a variety of solid tumors. Recently, it has been reported that the level before curative surgery is a prognostic factor for colorectal cancer (CRC). We investigated whether the plasma D-dimer level before systemic chemotherapies is a predictor for advanced or recurrent unresectable CRC. Methods: This study included 42 patients treated with systemic chemotherapies for advanced or recurrent unresectable CRC. Variables including clinicopathological factors, plasma D-dimer levels and the modified Glasgow Prognostic Factor Score (mGPS) were evaluated. Results: The plasma D-dimer level was closely related to the mGPS. Survival was shorter for patients with plasma D-dimer levels >5 μg/ml than for those with lower levels. Compared with an mGPS of 0 or 1, an mGPS of 2 was predictive of poor prognosis (p < 0.0001). Old age, advanced stage, plasma D-dimer level and mGPS were significantly associated with mortality, but plasma D-dimer level was the only independent risk factor in multivariate analysis, and was significant related to the clinical response to chemotherapy (p < 0.05). Conclusions: Survival was significantly shorter in patients with elevated plasma D-dimer levels having advanced or recurrent CRC. The plasma D-dimer level before systemic chemotherapies was an independent mortality predictor.

Original languageEnglish
Pages (from-to)10-15
Number of pages6
JournalOncology (Switzerland)
Volume83
Issue number1
DOIs
Publication statusPublished - Jul 1 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Yamamoto, M., Yoshinaga, K., Matsuyama, A., Iwasa, T., Osoegawa, A., Tsujita, E., Yamashita, Y., Tsutsui, S., & Ishida, T. (2012). Plasma d-dimer level as a mortality predictor in patients with advanced or recurrent colorectal cancer. Oncology (Switzerland), 83(1), 10-15. https://doi.org/10.1159/000338329