Plasma fibronectin and platelet aggregation in diabetes mellitus

Toyoshi Inoguchi; Fumio Umeda; Jun Watanabe; Taro Wasada; Hiroshi Ibayashi

doi:10.1016/S0168-8227(86)80062-6

Plasma fibronectin and platelet aggregation in diabetes mellitus

Toyoshi Inoguchi, Fumio Umeda, Jun Watanabe, Taro Wasada, Hiroshi Ibayashi

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Plasma fibronectin (FN) is a high-molecular weight glycoprotein produced by endothelial cells, fibroblasts, and other mesenchymal cells. Plasma FN levels were measured in non-insulin-dependent diabetics (NIDDM) (n = 42) and compared with age-matched control subjects (n = 20). Plasma FN levels were significantly higher in the NIDDM patients (44.2 ± 2.2 mg/dl, mean ± SE) than in the control subjects (31.2 ± 2.2 mg/dl). In addition, the rate of platelet aggregation was studied in 23 of the 42NIDDM patients. Interestingly, the plasma FN levels were significantly elevated, particularly in diabetic patients with enhanced platelet aggregation. It is suggested that elevated plasma FN may be closely related to the abnormality of platelet function in diabetics, which leads to diabetic vascular lesions.

Original language	English
Pages (from-to)	69-73
Number of pages	5
Journal	Diabetes Research and Clinical Practice
Volume	2
Issue number	2
DOIs	https://doi.org/10.1016/S0168-8227(86)80062-6
Publication status	Published - 1986

All Science Journal Classification (ASJC) codes

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0168-8227(86)80062-6

Cite this

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title = "Plasma fibronectin and platelet aggregation in diabetes mellitus",

abstract = "Plasma fibronectin (FN) is a high-molecular weight glycoprotein produced by endothelial cells, fibroblasts, and other mesenchymal cells. Plasma FN levels were measured in non-insulin-dependent diabetics (NIDDM) (n = 42) and compared with age-matched control subjects (n = 20). Plasma FN levels were significantly higher in the NIDDM patients (44.2 ± 2.2 mg/dl, mean ± SE) than in the control subjects (31.2 ± 2.2 mg/dl). In addition, the rate of platelet aggregation was studied in 23 of the 42NIDDM patients. Interestingly, the plasma FN levels were significantly elevated, particularly in diabetic patients with enhanced platelet aggregation. It is suggested that elevated plasma FN may be closely related to the abnormality of platelet function in diabetics, which leads to diabetic vascular lesions.",

author = "Toyoshi Inoguchi and Fumio Umeda and Jun Watanabe and Taro Wasada and Hiroshi Ibayashi",

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T1 - Plasma fibronectin and platelet aggregation in diabetes mellitus

AU - Inoguchi, Toyoshi

AU - Umeda, Fumio

AU - Watanabe, Jun

AU - Wasada, Taro

AU - Ibayashi, Hiroshi

PY - 1986

Y1 - 1986

N2 - Plasma fibronectin (FN) is a high-molecular weight glycoprotein produced by endothelial cells, fibroblasts, and other mesenchymal cells. Plasma FN levels were measured in non-insulin-dependent diabetics (NIDDM) (n = 42) and compared with age-matched control subjects (n = 20). Plasma FN levels were significantly higher in the NIDDM patients (44.2 ± 2.2 mg/dl, mean ± SE) than in the control subjects (31.2 ± 2.2 mg/dl). In addition, the rate of platelet aggregation was studied in 23 of the 42NIDDM patients. Interestingly, the plasma FN levels were significantly elevated, particularly in diabetic patients with enhanced platelet aggregation. It is suggested that elevated plasma FN may be closely related to the abnormality of platelet function in diabetics, which leads to diabetic vascular lesions.

AB - Plasma fibronectin (FN) is a high-molecular weight glycoprotein produced by endothelial cells, fibroblasts, and other mesenchymal cells. Plasma FN levels were measured in non-insulin-dependent diabetics (NIDDM) (n = 42) and compared with age-matched control subjects (n = 20). Plasma FN levels were significantly higher in the NIDDM patients (44.2 ± 2.2 mg/dl, mean ± SE) than in the control subjects (31.2 ± 2.2 mg/dl). In addition, the rate of platelet aggregation was studied in 23 of the 42NIDDM patients. Interestingly, the plasma FN levels were significantly elevated, particularly in diabetic patients with enhanced platelet aggregation. It is suggested that elevated plasma FN may be closely related to the abnormality of platelet function in diabetics, which leads to diabetic vascular lesions.

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Plasma fibronectin and platelet aggregation in diabetes mellitus

Abstract

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