Plasma fibronectin and platelet aggregation in diabetes mellitus

Toyoshi Inoguchi, Fumio Umeda, Jun Watanabe, Taro Wasada, Hiroshi Ibayashi

    Research output: Contribution to journalArticlepeer-review

    8 Citations (Scopus)

    Abstract

    Plasma fibronectin (FN) is a high-molecular weight glycoprotein produced by endothelial cells, fibroblasts, and other mesenchymal cells. Plasma FN levels were measured in non-insulin-dependent diabetics (NIDDM) (n = 42) and compared with age-matched control subjects (n = 20). Plasma FN levels were significantly higher in the NIDDM patients (44.2 ± 2.2 mg/dl, mean ± SE) than in the control subjects (31.2 ± 2.2 mg/dl). In addition, the rate of platelet aggregation was studied in 23 of the 42NIDDM patients. Interestingly, the plasma FN levels were significantly elevated, particularly in diabetic patients with enhanced platelet aggregation. It is suggested that elevated plasma FN may be closely related to the abnormality of platelet function in diabetics, which leads to diabetic vascular lesions.

    Original languageEnglish
    Pages (from-to)69-73
    Number of pages5
    JournalDiabetes Research and Clinical Practice
    Volume2
    Issue number2
    DOIs
    Publication statusPublished - 1986

    All Science Journal Classification (ASJC) codes

    • Internal Medicine
    • Endocrinology, Diabetes and Metabolism
    • Endocrinology

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