Abstract
Purpose: High-mobility group box 1 (HMGB-1) is a late-phase cytokine, which is released extracellularly in response to systemic inflammation caused by infection, shock, or trauma. We examined the plasma levels of HMGB-1 to clarify its role in surgical stress. Methods: The subjects of this study were 37 patients who underwent elective general surgery. We measured plasma concentrations of HMGB-1 over time using a quantitative enzyme-linked immunosorbent assay. We then analyzed the relationships between the change in HMGB-1 concentration and perioperative factors, including postoperative complications. Statistical analyses were performed using two-way repeated-measures analysis of variance. Results: The HMGB-1 level was higher on postoperative day 3 in patients with a prolonged operative time or large intraoperative blood loss (P = 0.048 and P = 0.041, respectively). The HMGB-1 level also remained high over time in patients with postoperative complications (P = 0.037). Conclusions: These results show that the plasma HMGB-1 level is related to surgical stress such as operative time and blood loss. The level remained high over time in patients with postoperative complication, suggesting progression of the complication.
| Original language | English |
|---|---|
| Pages (from-to) | 903-907 |
| Number of pages | 5 |
| Journal | Surgery today |
| Volume | 41 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 1 2011 |
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All Science Journal Classification (ASJC) codes
- Surgery
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Plasma high-mobility group box 1 as an indicator of surgical stress. / Osoegawa, Atsushi; Yano, Tokujiro; Yamanaka, Takeharu; Tagawa, Tetsuzo; Shoji, Fumihiro; Yoshino, Ichiro; Taketomi, Akinobu; Ito, Hiroyuki; Kakeji, Yoshihiro; Maehara, Yoshihiko.
In: Surgery today, Vol. 41, No. 7, 01.07.2011, p. 903-907.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Plasma high-mobility group box 1 as an indicator of surgical stress
AU - Osoegawa, Atsushi
AU - Yano, Tokujiro
AU - Yamanaka, Takeharu
AU - Tagawa, Tetsuzo
AU - Shoji, Fumihiro
AU - Yoshino, Ichiro
AU - Taketomi, Akinobu
AU - Ito, Hiroyuki
AU - Kakeji, Yoshihiro
AU - Maehara, Yoshihiko
PY - 2011/7/1
Y1 - 2011/7/1
N2 - Purpose: High-mobility group box 1 (HMGB-1) is a late-phase cytokine, which is released extracellularly in response to systemic inflammation caused by infection, shock, or trauma. We examined the plasma levels of HMGB-1 to clarify its role in surgical stress. Methods: The subjects of this study were 37 patients who underwent elective general surgery. We measured plasma concentrations of HMGB-1 over time using a quantitative enzyme-linked immunosorbent assay. We then analyzed the relationships between the change in HMGB-1 concentration and perioperative factors, including postoperative complications. Statistical analyses were performed using two-way repeated-measures analysis of variance. Results: The HMGB-1 level was higher on postoperative day 3 in patients with a prolonged operative time or large intraoperative blood loss (P = 0.048 and P = 0.041, respectively). The HMGB-1 level also remained high over time in patients with postoperative complications (P = 0.037). Conclusions: These results show that the plasma HMGB-1 level is related to surgical stress such as operative time and blood loss. The level remained high over time in patients with postoperative complication, suggesting progression of the complication.
AB - Purpose: High-mobility group box 1 (HMGB-1) is a late-phase cytokine, which is released extracellularly in response to systemic inflammation caused by infection, shock, or trauma. We examined the plasma levels of HMGB-1 to clarify its role in surgical stress. Methods: The subjects of this study were 37 patients who underwent elective general surgery. We measured plasma concentrations of HMGB-1 over time using a quantitative enzyme-linked immunosorbent assay. We then analyzed the relationships between the change in HMGB-1 concentration and perioperative factors, including postoperative complications. Statistical analyses were performed using two-way repeated-measures analysis of variance. Results: The HMGB-1 level was higher on postoperative day 3 in patients with a prolonged operative time or large intraoperative blood loss (P = 0.048 and P = 0.041, respectively). The HMGB-1 level also remained high over time in patients with postoperative complications (P = 0.037). Conclusions: These results show that the plasma HMGB-1 level is related to surgical stress such as operative time and blood loss. The level remained high over time in patients with postoperative complication, suggesting progression of the complication.
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U2 - 10.1007/s00595-010-4371-4
DO - 10.1007/s00595-010-4371-4
M3 - Article
C2 - 21748604
AN - SCOPUS:79960313208
VL - 41
SP - 903
EP - 907
JO - Surgery Today
JF - Surgery Today
SN - 0941-1291
IS - 7
ER -