Plasma homovanillic acid, plasma anti-D1 and -D2 dopamine-receptor activity, and negative symptoms in chronically medicated schizophrenia

Eiji Suzuki, Shigenobu Kanba, Masashi Nibuya, Hiroki Koshikawa, Toshio Nakai, Gohei Yagi

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We have investigated the relationship between the concentration of homovanillic acid in human plasma (pHVA) and plasma anti-D1 and anti-D2 dopamine receptor activity in chronic schizophrenic patients whose neuroleptic dosage was changed. The change in pHVA level correlated with that in anti-D1, not anti-D2 activity, thus suggesting that the neuroleptic-induced changes in pHVA concentration may be associated with the blocking of D1- as well as D2- receptors. The change of scores on the Scale for the Assessment of Negative Symptoms did not significantly correlated with changes in anti-D1 or anti-D2 activity, but did so correlated with the change in pHVA level.

Original languageEnglish
Pages (from-to)357-364
Number of pages8
JournalBiological Psychiatry
Issue number4
Publication statusPublished - Feb 15 1992
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Biological Psychiatry

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