Plasma S100A12 is associated with functional outcome after ischemic stroke: Research for Biomarkers in Ischemic Stroke

Yoshinobu Wakisaka, Tetsuro Ago, Masahiro Kamouchi, Jyunya Kuroda, Ryu Matsuo, Jun Hata, Seiji Gotoh, Tetsu Isomura, Hideto Awano, Kazuo Suzuki, Kenji Fukuda, Yasushi Okada, Yutaka Kiyohara, Hiroaki Ooboshi, Takanari Kitazono

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background Ischemic stroke is accompanied by an inflammatory response, which exacerbates brain injury and deteriorates functional outcome. S100A12 is expressed abundantly in granulocytes, and has been implicated to play an important role on inflammatory reactions in various disease states. We aimed to determine the association between plasma S100A12 levels and a functional outcome in patients with acute ischemic stroke. Methods We prospectively included 171 patients with acute ischemic stroke within 24 h after onset in this study. Plasma samples were collected for the measurement of S100A12 levels. Poor functional outcome was defined as a modified Rankin Scale of 2-6 at day 90 after stroke onset. Results Of 171 patients, 74 (43.3%) had a poor functional outcome at day 90 after stroke onset. Plasma S100A12 levels on admission were significantly higher in patients with a poor functional outcome (2.1 [1.2-5.1] ng/mL, median [interquartile]) than in those with a favorable outcome (1.1 [0.5-2.0] ng/mL; p < 0.001). Multivariate analysis showed that the highest quartile of plasma S100A12 levels on admission showed a significantly higher risk for a poor functional outcome (odds ratio, 4.01; 95% confidence interval, 1.09-16.10; p = 0.03) than the lowest quartile. Conclusions High plasma S100A12 levels on admission are associated with a poor functional outcome in patients with acute ischemic stroke.

Original languageEnglish
Pages (from-to)75-79
Number of pages5
JournalJournal of the Neurological Sciences
Volume340
Issue number1-2
DOIs
Publication statusPublished - May 15 2014

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Biomarkers
Stroke
Research
Granulocytes
Brain Injuries
S100A12 Protein
Multivariate Analysis
Odds Ratio
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Plasma S100A12 is associated with functional outcome after ischemic stroke : Research for Biomarkers in Ischemic Stroke. / Wakisaka, Yoshinobu; Ago, Tetsuro; Kamouchi, Masahiro; Kuroda, Jyunya; Matsuo, Ryu; Hata, Jun; Gotoh, Seiji; Isomura, Tetsu; Awano, Hideto; Suzuki, Kazuo; Fukuda, Kenji; Okada, Yasushi; Kiyohara, Yutaka; Ooboshi, Hiroaki; Kitazono, Takanari.

In: Journal of the Neurological Sciences, Vol. 340, No. 1-2, 15.05.2014, p. 75-79.

Research output: Contribution to journalArticle

Wakisaka, Yoshinobu ; Ago, Tetsuro ; Kamouchi, Masahiro ; Kuroda, Jyunya ; Matsuo, Ryu ; Hata, Jun ; Gotoh, Seiji ; Isomura, Tetsu ; Awano, Hideto ; Suzuki, Kazuo ; Fukuda, Kenji ; Okada, Yasushi ; Kiyohara, Yutaka ; Ooboshi, Hiroaki ; Kitazono, Takanari. / Plasma S100A12 is associated with functional outcome after ischemic stroke : Research for Biomarkers in Ischemic Stroke. In: Journal of the Neurological Sciences. 2014 ; Vol. 340, No. 1-2. pp. 75-79.
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abstract = "Background Ischemic stroke is accompanied by an inflammatory response, which exacerbates brain injury and deteriorates functional outcome. S100A12 is expressed abundantly in granulocytes, and has been implicated to play an important role on inflammatory reactions in various disease states. We aimed to determine the association between plasma S100A12 levels and a functional outcome in patients with acute ischemic stroke. Methods We prospectively included 171 patients with acute ischemic stroke within 24 h after onset in this study. Plasma samples were collected for the measurement of S100A12 levels. Poor functional outcome was defined as a modified Rankin Scale of 2-6 at day 90 after stroke onset. Results Of 171 patients, 74 (43.3{\%}) had a poor functional outcome at day 90 after stroke onset. Plasma S100A12 levels on admission were significantly higher in patients with a poor functional outcome (2.1 [1.2-5.1] ng/mL, median [interquartile]) than in those with a favorable outcome (1.1 [0.5-2.0] ng/mL; p < 0.001). Multivariate analysis showed that the highest quartile of plasma S100A12 levels on admission showed a significantly higher risk for a poor functional outcome (odds ratio, 4.01; 95{\%} confidence interval, 1.09-16.10; p = 0.03) than the lowest quartile. Conclusions High plasma S100A12 levels on admission are associated with a poor functional outcome in patients with acute ischemic stroke.",
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T1 - Plasma S100A12 is associated with functional outcome after ischemic stroke

T2 - Research for Biomarkers in Ischemic Stroke

AU - Wakisaka, Yoshinobu

AU - Ago, Tetsuro

AU - Kamouchi, Masahiro

AU - Kuroda, Jyunya

AU - Matsuo, Ryu

AU - Hata, Jun

AU - Gotoh, Seiji

AU - Isomura, Tetsu

AU - Awano, Hideto

AU - Suzuki, Kazuo

AU - Fukuda, Kenji

AU - Okada, Yasushi

AU - Kiyohara, Yutaka

AU - Ooboshi, Hiroaki

AU - Kitazono, Takanari

PY - 2014/5/15

Y1 - 2014/5/15

N2 - Background Ischemic stroke is accompanied by an inflammatory response, which exacerbates brain injury and deteriorates functional outcome. S100A12 is expressed abundantly in granulocytes, and has been implicated to play an important role on inflammatory reactions in various disease states. We aimed to determine the association between plasma S100A12 levels and a functional outcome in patients with acute ischemic stroke. Methods We prospectively included 171 patients with acute ischemic stroke within 24 h after onset in this study. Plasma samples were collected for the measurement of S100A12 levels. Poor functional outcome was defined as a modified Rankin Scale of 2-6 at day 90 after stroke onset. Results Of 171 patients, 74 (43.3%) had a poor functional outcome at day 90 after stroke onset. Plasma S100A12 levels on admission were significantly higher in patients with a poor functional outcome (2.1 [1.2-5.1] ng/mL, median [interquartile]) than in those with a favorable outcome (1.1 [0.5-2.0] ng/mL; p < 0.001). Multivariate analysis showed that the highest quartile of plasma S100A12 levels on admission showed a significantly higher risk for a poor functional outcome (odds ratio, 4.01; 95% confidence interval, 1.09-16.10; p = 0.03) than the lowest quartile. Conclusions High plasma S100A12 levels on admission are associated with a poor functional outcome in patients with acute ischemic stroke.

AB - Background Ischemic stroke is accompanied by an inflammatory response, which exacerbates brain injury and deteriorates functional outcome. S100A12 is expressed abundantly in granulocytes, and has been implicated to play an important role on inflammatory reactions in various disease states. We aimed to determine the association between plasma S100A12 levels and a functional outcome in patients with acute ischemic stroke. Methods We prospectively included 171 patients with acute ischemic stroke within 24 h after onset in this study. Plasma samples were collected for the measurement of S100A12 levels. Poor functional outcome was defined as a modified Rankin Scale of 2-6 at day 90 after stroke onset. Results Of 171 patients, 74 (43.3%) had a poor functional outcome at day 90 after stroke onset. Plasma S100A12 levels on admission were significantly higher in patients with a poor functional outcome (2.1 [1.2-5.1] ng/mL, median [interquartile]) than in those with a favorable outcome (1.1 [0.5-2.0] ng/mL; p < 0.001). Multivariate analysis showed that the highest quartile of plasma S100A12 levels on admission showed a significantly higher risk for a poor functional outcome (odds ratio, 4.01; 95% confidence interval, 1.09-16.10; p = 0.03) than the lowest quartile. Conclusions High plasma S100A12 levels on admission are associated with a poor functional outcome in patients with acute ischemic stroke.

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