Plasmacytoid dendritic cells activate lymphoid-specific genetic programs irrespective of their cellular origin

Hirokazu Shigematsu, Boris Reizis, Hiromi Iwasaki, Shin Ichi Mizuno, Dan Hu, David Traver, Philip Leder, Nobuo Sakaguchi, Koichi Akashi

Research output: Contribution to journalArticle

164 Citations (Scopus)

Abstract

The developmental origin of type I interferon (IFN)-producing plasmacytoid dendritic cells (PDCs) is controversial. In particular, the rearrangement of immunoglobulin heavy chain (IgH) genes in murine PDCs and the expression of pre-T cell receptor α (pTα) gene by human PDCs were proposed as evidence for their "lymphoid" origin. Here we demonstrate that PDCs capable of IFN production develop efficiently from both myeloid- and lymphoid-committed progenitors. Rearranged IgH genes as well as RAG transcripts were found in both myeloid- and lymphoid-derived PDCs. The human pTα transgenic reporter was activated in both myeloid- and lymphoid-derived PDCs at a level comparable to pre-T cells. PDCs were the only cell population that activated murine RAG1 knockin and human pTα transgenic reporters outside the lymphoid lineage. These results highlight a unique developmental program of PDCs that distinguishes them from other cell types including conventional dendritic cells.

Original languageEnglish
Pages (from-to)43-53
Number of pages11
JournalImmunity
Volume21
Issue number1
DOIs
Publication statusPublished - Jul 1 2004

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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