TY - JOUR
T1 - Plastin3 is associated with epithelial-mesenchymal transition and poor prognosis in gastric cancer
AU - Kurashige, Junji
AU - Yokobori, Takehiro
AU - Mima, Kosuke
AU - Sawada, Genta
AU - Takahashi, Yusuke
AU - Ueo, Hiroki
AU - Takano, Yuki
AU - Matsumura, T. A.E.
AU - Uchi, Ryutaro
AU - Eguchi, Hidetoshi
AU - Sudo, Tomoya
AU - Sugimachi, Keishi
AU - Mori, Masaki
AU - Baba, Hideo
AU - Mimori, Koshi
N1 - Publisher Copyright:
© 2019, Spandidos Publications. All rights reserved.
PY - 2019/2
Y1 - 2019/2
N2 - The plastin3 (PLS3) gene, which encodes an actin bundling protein known to inhibit cofilin-mediated depoly-merization of actin fiber, has been previously reported to serve an important role in the epithelial-mesenchymal transition (EMT) in cancer. The aim of the present study was to determine the clinical significance of PLS3 and its role in regulating EMT, as well as in promoting cell invasion and migration in gastric cancer. The expression of plastin3 mRNA was measured in 163 resected gastric cancer specimens, in order to determine the clinicopathological significance. Furthermore, in vitro invasion and migration assays were performed on gastric cancer cells, which revealed that PLS3 expression was suppressed. The high PLS3 expression group had a higher incidence of advanced tumour stage, cancer differentiation, tumour invasion depth and distant metastases compared with the low PLS3 expression group (P<0.05). In addition, the high PLS3 expression group had a significantly poorer prognosis than the low expression group (P=0.012). Multivariate analysis indicated that high PLS3 expression was an independent prognostic factor for survival. The present study also identified that suppression of PLS3 in gastric cancer cells was associated with decreased cell invasion and migration. The findings from the present study indicate that high expression of PLS3 in gastric cancer is independently associated with a poor prognosis, and that PL3 serves an important role in EMT.
AB - The plastin3 (PLS3) gene, which encodes an actin bundling protein known to inhibit cofilin-mediated depoly-merization of actin fiber, has been previously reported to serve an important role in the epithelial-mesenchymal transition (EMT) in cancer. The aim of the present study was to determine the clinical significance of PLS3 and its role in regulating EMT, as well as in promoting cell invasion and migration in gastric cancer. The expression of plastin3 mRNA was measured in 163 resected gastric cancer specimens, in order to determine the clinicopathological significance. Furthermore, in vitro invasion and migration assays were performed on gastric cancer cells, which revealed that PLS3 expression was suppressed. The high PLS3 expression group had a higher incidence of advanced tumour stage, cancer differentiation, tumour invasion depth and distant metastases compared with the low PLS3 expression group (P<0.05). In addition, the high PLS3 expression group had a significantly poorer prognosis than the low expression group (P=0.012). Multivariate analysis indicated that high PLS3 expression was an independent prognostic factor for survival. The present study also identified that suppression of PLS3 in gastric cancer cells was associated with decreased cell invasion and migration. The findings from the present study indicate that high expression of PLS3 in gastric cancer is independently associated with a poor prognosis, and that PL3 serves an important role in EMT.
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U2 - 10.3892/ol.2018.9819
DO - 10.3892/ol.2018.9819
M3 - Article
AN - SCOPUS:85059608028
SN - 1792-1074
VL - 17
SP - 2393
EP - 2399
JO - Oncology Letters
JF - Oncology Letters
IS - 2
ER -
