Platelet-activating factor receptor gene polymorphism in Japanese patients with multiple sclerosis

Manabu Osoegawa, Ryuji Miyagishi, Hirofumi Ochi, Itta Nakamura, Masaaki Niino, Seiji Kikuchi, Hiroyuki Murai, Toshiyuki Fukazawa, Motozumi Minohara, Kunio Tashiro, Jun Ichi Kira

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Abstract

We evaluated the association of the platelet-activating factor receptor (PAFR) gene polymorphism (A224D) with the susceptibility and severity of multiple sclerosis (MS) in a Japanese population. DNA was collected from 162 Japanese patients with clinically definite 'conventional' MS (MS) and 245 healthy controls. The missense mutation A224D that impairs PAF-PAFR signaling was determined by polymerase chain reaction restriction fragment length polymorphism. The frequency of the AD/DD genotypes was significantly higher in MS patients (21.0%) than in healthy controls (13.5%) (p=0.045; odds ratio (OR), 1.71; 95% confidence interval (CI), 1.01-2.89). Moreover, the frequency of D allele in MS patients (11.7%) was also significantly higher than those in healthy controls (6.9%) (p=0.019; OR, 1.78; 95% CI, 1.10-2.89). These findings suggest that the PAFR gene missense mutation has a relation to the susceptibility for MS.

Original languageEnglish
Pages (from-to)195-198
Number of pages4
JournalJournal of Neuroimmunology
Volume161
Issue number1-2
DOIs
Publication statusPublished - Apr 2005

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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    Osoegawa, M., Miyagishi, R., Ochi, H., Nakamura, I., Niino, M., Kikuchi, S., Murai, H., Fukazawa, T., Minohara, M., Tashiro, K., & Kira, J. I. (2005). Platelet-activating factor receptor gene polymorphism in Japanese patients with multiple sclerosis. Journal of Neuroimmunology, 161(1-2), 195-198. https://doi.org/10.1016/j.jneuroim.2004.12.014