Platelet Activation Markers Are Associated with Crohn’s Disease Activity in Patients with Low C-Reactive Protein

Hiroshi Takeyama, Tsunekazu Mizushima, Hideki Iijima, Shinzaki Shinichiro, Mamoru Uemura, Junichi Nishimura, Taishi Hata, Ichiro Takemasa, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: In assessing Crohn’s disease (CD) activity, C-reactive protein (CRP) is an important indicator of inflammation; however, it is not necessarily associated with the Crohn’s Disease Activity Index (CDAI), particularly in patients with low CRP. Recently, platelet activation factors have been recognized due to their importance in the inflammatory response. In this study, we examined associations between the CDAI and platelet factor 4 (PF-4), β-thromboglobulin (β-TG), and other coagulation and fibrinolysis factors. Aims: We aimed to find a new marker for evaluating disease activity in patients with CD and low CRP. Methods: Nine markers, including CRP, platelet count, white blood cell count, fibrin and fibrinogen degradation product, fibrinogen, thrombin–antithrombin complex, prothrombin fragments 1 + 2, PF-4, and β-TG were evaluated in 47 patients with CD and low CRP (<1.0 mg/dl). Patients were assigned to high or low disease activity groups, CDAI-H (CDAI ≥ 150) and CDAI-L (CDAI < 150), respectively. Results: CDAI-H exhibited significantly higher PF-4 and β-TG levels than CDAI-L (P < 0.01). Other markers were not significantly different between groups. CDAI was positively correlated with the levels of PF-4 and β-TG (P = 0.0033 and 0.0024; r = 0.4202 and 0.4321, respectively). Receiver operating characteristic curve analyses of PF-4 and β-TG showed high sensitivity (61.9 and 81 %, respectively) and specificity (84.7 and 69.2 %, respectively) for diagnosing active CD. Conclusion: Among eight potential markers, PF-4 and β-TG were the most highly correlated with CDAI in patients with CD and low CRP. PF-4 and β-TG levels showed promise as new markers for assessing CD in patients with low CRP.

Original languageEnglish
Pages (from-to)3418-3423
Number of pages6
JournalDigestive Diseases and Sciences
Volume60
Issue number11
DOIs
Publication statusPublished - Nov 1 2015
Externally publishedYes

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Platelet Activation
Crohn Disease
C-Reactive Protein
Platelet Factor 4
Fibrin Fibrinogen Degradation Products
Blood Coagulation Factors
Fibrinolysis
Platelet Count
Leukocyte Count
ROC Curve
Fibrinogen

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

Cite this

Platelet Activation Markers Are Associated with Crohn’s Disease Activity in Patients with Low C-Reactive Protein. / Takeyama, Hiroshi; Mizushima, Tsunekazu; Iijima, Hideki; Shinichiro, Shinzaki; Uemura, Mamoru; Nishimura, Junichi; Hata, Taishi; Takemasa, Ichiro; Yamamoto, Hirofumi; Doki, Yuichiro; Mori, Masaki.

In: Digestive Diseases and Sciences, Vol. 60, No. 11, 01.11.2015, p. 3418-3423.

Research output: Contribution to journalArticle

Takeyama, H, Mizushima, T, Iijima, H, Shinichiro, S, Uemura, M, Nishimura, J, Hata, T, Takemasa, I, Yamamoto, H, Doki, Y & Mori, M 2015, 'Platelet Activation Markers Are Associated with Crohn’s Disease Activity in Patients with Low C-Reactive Protein', Digestive Diseases and Sciences, vol. 60, no. 11, pp. 3418-3423. https://doi.org/10.1007/s10620-015-3745-2
Takeyama, Hiroshi ; Mizushima, Tsunekazu ; Iijima, Hideki ; Shinichiro, Shinzaki ; Uemura, Mamoru ; Nishimura, Junichi ; Hata, Taishi ; Takemasa, Ichiro ; Yamamoto, Hirofumi ; Doki, Yuichiro ; Mori, Masaki. / Platelet Activation Markers Are Associated with Crohn’s Disease Activity in Patients with Low C-Reactive Protein. In: Digestive Diseases and Sciences. 2015 ; Vol. 60, No. 11. pp. 3418-3423.
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abstract = "Background: In assessing Crohn’s disease (CD) activity, C-reactive protein (CRP) is an important indicator of inflammation; however, it is not necessarily associated with the Crohn’s Disease Activity Index (CDAI), particularly in patients with low CRP. Recently, platelet activation factors have been recognized due to their importance in the inflammatory response. In this study, we examined associations between the CDAI and platelet factor 4 (PF-4), β-thromboglobulin (β-TG), and other coagulation and fibrinolysis factors. Aims: We aimed to find a new marker for evaluating disease activity in patients with CD and low CRP. Methods: Nine markers, including CRP, platelet count, white blood cell count, fibrin and fibrinogen degradation product, fibrinogen, thrombin–antithrombin complex, prothrombin fragments 1 + 2, PF-4, and β-TG were evaluated in 47 patients with CD and low CRP (<1.0 mg/dl). Patients were assigned to high or low disease activity groups, CDAI-H (CDAI ≥ 150) and CDAI-L (CDAI < 150), respectively. Results: CDAI-H exhibited significantly higher PF-4 and β-TG levels than CDAI-L (P < 0.01). Other markers were not significantly different between groups. CDAI was positively correlated with the levels of PF-4 and β-TG (P = 0.0033 and 0.0024; r = 0.4202 and 0.4321, respectively). Receiver operating characteristic curve analyses of PF-4 and β-TG showed high sensitivity (61.9 and 81 {\%}, respectively) and specificity (84.7 and 69.2 {\%}, respectively) for diagnosing active CD. Conclusion: Among eight potential markers, PF-4 and β-TG were the most highly correlated with CDAI in patients with CD and low CRP. PF-4 and β-TG levels showed promise as new markers for assessing CD in patients with low CRP.",
author = "Hiroshi Takeyama and Tsunekazu Mizushima and Hideki Iijima and Shinzaki Shinichiro and Mamoru Uemura and Junichi Nishimura and Taishi Hata and Ichiro Takemasa and Hirofumi Yamamoto and Yuichiro Doki and Masaki Mori",
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AU - Takeyama, Hiroshi

AU - Mizushima, Tsunekazu

AU - Iijima, Hideki

AU - Shinichiro, Shinzaki

AU - Uemura, Mamoru

AU - Nishimura, Junichi

AU - Hata, Taishi

AU - Takemasa, Ichiro

AU - Yamamoto, Hirofumi

AU - Doki, Yuichiro

AU - Mori, Masaki

PY - 2015/11/1

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N2 - Background: In assessing Crohn’s disease (CD) activity, C-reactive protein (CRP) is an important indicator of inflammation; however, it is not necessarily associated with the Crohn’s Disease Activity Index (CDAI), particularly in patients with low CRP. Recently, platelet activation factors have been recognized due to their importance in the inflammatory response. In this study, we examined associations between the CDAI and platelet factor 4 (PF-4), β-thromboglobulin (β-TG), and other coagulation and fibrinolysis factors. Aims: We aimed to find a new marker for evaluating disease activity in patients with CD and low CRP. Methods: Nine markers, including CRP, platelet count, white blood cell count, fibrin and fibrinogen degradation product, fibrinogen, thrombin–antithrombin complex, prothrombin fragments 1 + 2, PF-4, and β-TG were evaluated in 47 patients with CD and low CRP (<1.0 mg/dl). Patients were assigned to high or low disease activity groups, CDAI-H (CDAI ≥ 150) and CDAI-L (CDAI < 150), respectively. Results: CDAI-H exhibited significantly higher PF-4 and β-TG levels than CDAI-L (P < 0.01). Other markers were not significantly different between groups. CDAI was positively correlated with the levels of PF-4 and β-TG (P = 0.0033 and 0.0024; r = 0.4202 and 0.4321, respectively). Receiver operating characteristic curve analyses of PF-4 and β-TG showed high sensitivity (61.9 and 81 %, respectively) and specificity (84.7 and 69.2 %, respectively) for diagnosing active CD. Conclusion: Among eight potential markers, PF-4 and β-TG were the most highly correlated with CDAI in patients with CD and low CRP. PF-4 and β-TG levels showed promise as new markers for assessing CD in patients with low CRP.

AB - Background: In assessing Crohn’s disease (CD) activity, C-reactive protein (CRP) is an important indicator of inflammation; however, it is not necessarily associated with the Crohn’s Disease Activity Index (CDAI), particularly in patients with low CRP. Recently, platelet activation factors have been recognized due to their importance in the inflammatory response. In this study, we examined associations between the CDAI and platelet factor 4 (PF-4), β-thromboglobulin (β-TG), and other coagulation and fibrinolysis factors. Aims: We aimed to find a new marker for evaluating disease activity in patients with CD and low CRP. Methods: Nine markers, including CRP, platelet count, white blood cell count, fibrin and fibrinogen degradation product, fibrinogen, thrombin–antithrombin complex, prothrombin fragments 1 + 2, PF-4, and β-TG were evaluated in 47 patients with CD and low CRP (<1.0 mg/dl). Patients were assigned to high or low disease activity groups, CDAI-H (CDAI ≥ 150) and CDAI-L (CDAI < 150), respectively. Results: CDAI-H exhibited significantly higher PF-4 and β-TG levels than CDAI-L (P < 0.01). Other markers were not significantly different between groups. CDAI was positively correlated with the levels of PF-4 and β-TG (P = 0.0033 and 0.0024; r = 0.4202 and 0.4321, respectively). Receiver operating characteristic curve analyses of PF-4 and β-TG showed high sensitivity (61.9 and 81 %, respectively) and specificity (84.7 and 69.2 %, respectively) for diagnosing active CD. Conclusion: Among eight potential markers, PF-4 and β-TG were the most highly correlated with CDAI in patients with CD and low CRP. PF-4 and β-TG levels showed promise as new markers for assessing CD in patients with low CRP.

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