Platelet-derived growth factor and bone morphogenetic protein in the healing of mandibular fractures in rats

Linda Rasubala, H. Yoshikawa, K. Nagata, T. Iijima, M. Ohishi

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

We studied the effects of platelet-derived growth factor-B (PDGF-B) and bone morphogenetic protein-2 (BMP-2) during the healing of mandibular closed fractures in rats by immunohistochemical methods. Unilateral closed fractures were created in the mandibles of thirty 12-week-old rats. BMP-2 was expressed during all stages of healing, but PDGF-B was expressed mainly in the early and middle stages, and not in the later stage of the healing process. We conclude that PDGF-B was associated with the proliferation and migration of primitive mesenchymal cells. BMP-2 was related to the differentiation of mesenchymal cells into osteoblasts and chondroblasts. PDGF-B and BMP-2 both have distinct regulatory effects on the healing of fractures.

Original languageEnglish
Pages (from-to)173-178
Number of pages6
JournalBritish Journal of Oral and Maxillofacial Surgery
Volume41
Issue number3
DOIs
Publication statusPublished - Jun 2003

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

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