Platelet-derived growth factor B-chain-like immunoreactivity in injured rat brain

Shoukei Takayama, Masakiyo Sasahara, Koji Iihara, Jyoji Handa, Fumitada Hazama

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Platelet-derived growth factor (PDGF) is a potent mitogen for mesenchymal cells and glial cells. For a better understanding of the role of PDGF B-chain in the brain, the expression of PDGF B-chain was examined immunohistochemically in penetrating injury to the rat brain. Shrunken neurons were distributed with enhanced PDGF B-chain-related immunoreactivity (PBRI) in the vicinity of the lesion during a period from day 1 to day 4 post injury. Platelet-derived growth factor B-chain-related immunoreactivity was transiently observed also in the cytoplasm of the numerous brain macrophages in the lesion on day 3 and day 4. These distributions of PBRI in the lesion were closely related to the neovascularization and astrogliosis there. The close time and spatial correlation between the expression of PBRI and cellular responses to injury seen in this study suggests PDGF B-chain has an important role in the healing process of cerebral wound.

Original languageEnglish
Pages (from-to)131-140
Number of pages10
JournalBrain Research
Volume653
Issue number1-2
DOIs
Publication statusPublished - Aug 8 1994
Externally publishedYes

Fingerprint

Proto-Oncogene Proteins c-sis
Brain
Wounds and Injuries
Platelet-Derived Growth Factor
Mitogens
Neuroglia
Cytoplasm
Macrophages
Neurons

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Platelet-derived growth factor B-chain-like immunoreactivity in injured rat brain. / Takayama, Shoukei; Sasahara, Masakiyo; Iihara, Koji; Handa, Jyoji; Hazama, Fumitada.

In: Brain Research, Vol. 653, No. 1-2, 08.08.1994, p. 131-140.

Research output: Contribution to journalArticle

Takayama, Shoukei ; Sasahara, Masakiyo ; Iihara, Koji ; Handa, Jyoji ; Hazama, Fumitada. / Platelet-derived growth factor B-chain-like immunoreactivity in injured rat brain. In: Brain Research. 1994 ; Vol. 653, No. 1-2. pp. 131-140.
@article{16624117c7af41ea83d11895b35d9b1a,
title = "Platelet-derived growth factor B-chain-like immunoreactivity in injured rat brain",
abstract = "Platelet-derived growth factor (PDGF) is a potent mitogen for mesenchymal cells and glial cells. For a better understanding of the role of PDGF B-chain in the brain, the expression of PDGF B-chain was examined immunohistochemically in penetrating injury to the rat brain. Shrunken neurons were distributed with enhanced PDGF B-chain-related immunoreactivity (PBRI) in the vicinity of the lesion during a period from day 1 to day 4 post injury. Platelet-derived growth factor B-chain-related immunoreactivity was transiently observed also in the cytoplasm of the numerous brain macrophages in the lesion on day 3 and day 4. These distributions of PBRI in the lesion were closely related to the neovascularization and astrogliosis there. The close time and spatial correlation between the expression of PBRI and cellular responses to injury seen in this study suggests PDGF B-chain has an important role in the healing process of cerebral wound.",
author = "Shoukei Takayama and Masakiyo Sasahara and Koji Iihara and Jyoji Handa and Fumitada Hazama",
year = "1994",
month = "8",
day = "8",
doi = "10.1016/0006-8993(94)90381-6",
language = "English",
volume = "653",
pages = "131--140",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Platelet-derived growth factor B-chain-like immunoreactivity in injured rat brain

AU - Takayama, Shoukei

AU - Sasahara, Masakiyo

AU - Iihara, Koji

AU - Handa, Jyoji

AU - Hazama, Fumitada

PY - 1994/8/8

Y1 - 1994/8/8

N2 - Platelet-derived growth factor (PDGF) is a potent mitogen for mesenchymal cells and glial cells. For a better understanding of the role of PDGF B-chain in the brain, the expression of PDGF B-chain was examined immunohistochemically in penetrating injury to the rat brain. Shrunken neurons were distributed with enhanced PDGF B-chain-related immunoreactivity (PBRI) in the vicinity of the lesion during a period from day 1 to day 4 post injury. Platelet-derived growth factor B-chain-related immunoreactivity was transiently observed also in the cytoplasm of the numerous brain macrophages in the lesion on day 3 and day 4. These distributions of PBRI in the lesion were closely related to the neovascularization and astrogliosis there. The close time and spatial correlation between the expression of PBRI and cellular responses to injury seen in this study suggests PDGF B-chain has an important role in the healing process of cerebral wound.

AB - Platelet-derived growth factor (PDGF) is a potent mitogen for mesenchymal cells and glial cells. For a better understanding of the role of PDGF B-chain in the brain, the expression of PDGF B-chain was examined immunohistochemically in penetrating injury to the rat brain. Shrunken neurons were distributed with enhanced PDGF B-chain-related immunoreactivity (PBRI) in the vicinity of the lesion during a period from day 1 to day 4 post injury. Platelet-derived growth factor B-chain-related immunoreactivity was transiently observed also in the cytoplasm of the numerous brain macrophages in the lesion on day 3 and day 4. These distributions of PBRI in the lesion were closely related to the neovascularization and astrogliosis there. The close time and spatial correlation between the expression of PBRI and cellular responses to injury seen in this study suggests PDGF B-chain has an important role in the healing process of cerebral wound.

UR - http://www.scopus.com/inward/record.url?scp=0028016037&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028016037&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(94)90381-6

DO - 10.1016/0006-8993(94)90381-6

M3 - Article

C2 - 7526956

AN - SCOPUS:0028016037

VL - 653

SP - 131

EP - 140

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1-2

ER -