Platelet-derived growth factor-BB, but not -AA, prevents delayed neuronal death after forebrain ischemia in rats

Koji Iihara, Nobuo Hashimoto, Tetsuya Tsukahara, Masahiro Sakata, Hiroji Yanamoto, Takashi Taniguchi

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Our previous studies demonstrated coordinate expression of platelet- derived growth factor (PDGF) -B chain and β-receptor in neurons at risk in the rat brain with focal ischemia. To clarify a role of the -B chain in the brain further, we examined whether PDGF-A or -B chain protects CA1 pyramidal neurons from delayed neuronal death after forebrain ischemia in rats. Pretreatment with PDGF-BB, but not -AA, at 120 ng/d for 2 days until forebrain ischemia was performed markedly ameliorated delayed neuronal death in CA1 pyramidal neurons on day 7 after ischemia. This neuroprotective effect of PDGF-BB was dose-dependent, and pretreatment with PDGF-BB at 240 ng/d showed almost complete inhibition of delayed neuronal death. In contrast, posttreatment with PDGF-BB at 120 ng/d starting 20 minutes after ischemia demonstrated no significant neuroprotective effect. The current study established marked neuroprotective actions of PDGF-BB in ischemic neuronal damage.

Original languageEnglish
Pages (from-to)1097-1106
Number of pages10
JournalJournal of Cerebral Blood Flow and Metabolism
Volume17
Issue number10
DOIs
Publication statusPublished - Oct 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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