Platelets as an indicator of vascular repair in elderly Japanese men

Yuji Shimizu, Shimpei Sato, Jun Koyamatsu, Hirotomo Yamanashi, Mako Nagayoshi, Koichiro Kadota, Takahiro Maeda

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Platelets and circulating CD34-positive cells have been reported to contribute to vascular repair (endothelial repair and developing atherosclerosis). And because hypertension is known to be a strong vascular impairment factors, it should also influence the respective numbers of these factors. To clarify the clinical importance of platelets on vascular repair, we conducted a cross-sectional study of 567 Japanese men aged 60-69 who underwent an annual health check-up between 2013 and 2015. Multiple linear regression analysis of non-hypertensive subjects adjusting for classical cardiovascular risk factors showed that although platelet count did not significantly correlate with carotid intima media thickness (β = -0.05, p = 0.356), it did positively correlate significantly with the natural log of the number of circulating CD34-positive cells (β = 0.26, p < 0.001). In hypertensive subjects, a significant positive correlation was seen between platelets and intima media thickness (β = 0.19, p = 0.008), whereas no significant correlation was seen between platelet count and the natural log of the number of circulating CD34-positive cells (β = 0.11, p = 0.119). Our results indicate that platelet count is an indicator of vascular repair activity (endothelial repair and developing atherosclerosis). Additionally, hypertension might mask the beneficial effects of circulating CD34-positive cells.

Original languageEnglish
Pages (from-to)44919-44926
Number of pages8
JournalOncotarget
Volume7
Issue number29
DOIs
Publication statusPublished - Jan 1 2016

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Blood Vessels
Blood Platelets
Platelet Count
Atherosclerosis
Hypertension
Carotid Intima-Media Thickness
Masks
Linear Models
Cross-Sectional Studies
Regression Analysis
Health

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Shimizu, Y., Sato, S., Koyamatsu, J., Yamanashi, H., Nagayoshi, M., Kadota, K., & Maeda, T. (2016). Platelets as an indicator of vascular repair in elderly Japanese men. Oncotarget, 7(29), 44919-44926. https://doi.org/10.18632/oncotarget.10229

Platelets as an indicator of vascular repair in elderly Japanese men. / Shimizu, Yuji; Sato, Shimpei; Koyamatsu, Jun; Yamanashi, Hirotomo; Nagayoshi, Mako; Kadota, Koichiro; Maeda, Takahiro.

In: Oncotarget, Vol. 7, No. 29, 01.01.2016, p. 44919-44926.

Research output: Contribution to journalArticle

Shimizu, Y, Sato, S, Koyamatsu, J, Yamanashi, H, Nagayoshi, M, Kadota, K & Maeda, T 2016, 'Platelets as an indicator of vascular repair in elderly Japanese men', Oncotarget, vol. 7, no. 29, pp. 44919-44926. https://doi.org/10.18632/oncotarget.10229
Shimizu Y, Sato S, Koyamatsu J, Yamanashi H, Nagayoshi M, Kadota K et al. Platelets as an indicator of vascular repair in elderly Japanese men. Oncotarget. 2016 Jan 1;7(29):44919-44926. https://doi.org/10.18632/oncotarget.10229
Shimizu, Yuji ; Sato, Shimpei ; Koyamatsu, Jun ; Yamanashi, Hirotomo ; Nagayoshi, Mako ; Kadota, Koichiro ; Maeda, Takahiro. / Platelets as an indicator of vascular repair in elderly Japanese men. In: Oncotarget. 2016 ; Vol. 7, No. 29. pp. 44919-44926.
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