Platinum-catalyzed direct amination of allylic alcohols

Takashi Ohshima, Kazushi Mashima

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Transition metal-catalyzed amination of allylic compounds via a π -allylmetal intermediate is a powerful and useful method for synthesizing allylamines. Direct catalytic substitution of allylic alcohols with amines, which forms water as the sole coproduct, has recently attracted attention in terms of its environmental and economical advantages. Here, we describe the development of a direct catalytic amination of both aryl-and alkyl-substituted allylic alcohols with various amines including the smallest nitrogen nucleophile ammonia using Pt-Xantphos and Pt-DPEphos catalyst systems, which allow the selective synthesis of various monoallylamines including the biologically active compounds naftiflne and flunarizine, in good to high yield without requiring any activator.

Original languageEnglish
Pages (from-to)1145-1156
Number of pages12
JournalYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
Volume70
Issue number11
DOIs
Publication statusPublished - 2012

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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