Platinum(II)-glutamic acid dendrimer conjugates

Synthesis, characterization, DFT calculation, conformational analysis and catalytic properties

Anas Lataifeh, Heinz Bernhard Kraatz, Firas F. Awwadi, Mohammed A. Zaitoun, Ken Sakai

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A series of platinum(II)-L-glutamic acid dendrimer conjugates having the formula PtCl2(5,5′-Gn(OR)-2,2′-bipyridine); Gn (n = 0, 1, 2), have been synthesized by various amide bond formation methods. The dendrimer complexes were terminated as carboxylic acid (R = H) or methyloxy ester (R = Me). The complexes were characterized by mass spectrometry, elemental analysis, UV-vis, FTIR, 1H-, 13C NMR, 1H-TOCSY, HSQC. The G1(OH) complex aggregate in solution and solid state, giving rise to a rigid conformation for the glutmaic acid side chain. The G2(OH) exists in the “monomeric” form with several conformations for the glutamic acid side chains. Complexes terminated with carboxyl group (R = H) were active catalyst toward hydrogen gas (H2) production by photo-induced splitting of water. The turnover frequency (TOF) for the G1(OH) complex is 14.7 × 1015 s−1, and it exhibits a ∼ 2-fold enhancement in H2 production compared to the unmodified parent complex G0(OH) (TOF = 7×1015 s−1). While G2(OH) complex displayed a lower hydrogen activity (TOF = 3.8 × 1015 s−1) compared to G0(OH). The platinum-glutamic acid dendrimer conjugates showed a correlation between H2 evolution activity and their ability to form aggregates, which driven by the steric hindrance of the peptide residues in the vicinity of Pt-center.

Original languageEnglish
Pages (from-to)245-254
Number of pages10
JournalInorganica Chimica Acta
Volume473
DOIs
Publication statusPublished - Mar 24 2018

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Dendrimers
glutamic acid
dendrimers
Platinum
Discrete Fourier transforms
Glutamic Acid
platinum
Acids
Conformations
Hydrogen
synthesis
carboxyl group
hydrogen
Carboxylic Acids
Amides
carboxylic acids
amides
peptides
Mass spectrometry
esters

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

Cite this

Platinum(II)-glutamic acid dendrimer conjugates : Synthesis, characterization, DFT calculation, conformational analysis and catalytic properties. / Lataifeh, Anas; Kraatz, Heinz Bernhard; Awwadi, Firas F.; Zaitoun, Mohammed A.; Sakai, Ken.

In: Inorganica Chimica Acta, Vol. 473, 24.03.2018, p. 245-254.

Research output: Contribution to journalArticle

Lataifeh, Anas ; Kraatz, Heinz Bernhard ; Awwadi, Firas F. ; Zaitoun, Mohammed A. ; Sakai, Ken. / Platinum(II)-glutamic acid dendrimer conjugates : Synthesis, characterization, DFT calculation, conformational analysis and catalytic properties. In: Inorganica Chimica Acta. 2018 ; Vol. 473. pp. 245-254.
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