Plexin: A novel neuronal cell surface molecule that mediates cell adhesion via a homophilic binding mechanism in the presence of calcium ions

Kunimasa Ohta, Akihito Mizutani, Atsushi Kawakami, Yasunori Murakami, Yasuyo Kasuya, Shin Takagi, Hideaki Tanaka, Hajime Fujisawa

Research output: Contribution to journalArticlepeer-review

115 Citations (Scopus)

Abstract

Plexin (previously referred to as 132) is a neuronal cell surface molecule that has been identified in Xenopus. cDNA cloning reveals that plexin has no homology to known neuronal cell surface molecules but possesses, in its extracellular segment, three internal repeats of cysteine clusters that are homologous to the cysteine-rich domain of the c-met proto-oncogene protein product. The exogenous plexin proteins expressed on the surfaces of L cells by cDNA transfection mediate cell adhesion via a homophilic binding mechanism, under the presence of calcium ions. Plexin is expressed in the receptors and neurons of particular sensory systems. These findings indicate that plexin is a novel calcium-dependent cell adhesion molecule and suggest its involvement in specific neuronal cell interaction and/or contact.

Original languageEnglish
Pages (from-to)1189-1199
Number of pages11
JournalNeuron
Volume14
Issue number6
DOIs
Publication statusPublished - Jun 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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