Pneumocystis carinii pneumonia in Diamond-Blackfan anemia: The necessity of chemoprophylaxis for young infants

A. Nomura, S. Ohga, Y. Asaka, H. Takada, F. Nakao, K. Kusuhara, T. Hara

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Two infants with Diamond-Blackfan anemia (DBA) developed Pneumocystis carinii pneumonia during corticosteroid (CS) therapy. Both patients showed the typical prodrome of tachypnea and fever, and the chest X-ray findings of interstitial infiltration, along with high serum levels of β-D-glucan and undetectable levels of endotoxin. The PCR study of bronchoalveolar lavage fluid was positive for P. carinii DNA in a 4-month-old infant, although it was not available in the previous case of a 2-month-old infant. No other causative agents were defined. They had no predisposing immunodeficiency diseases. Prophylaxis against P. carinii infection must be considered for young infants with DBA during the first CS therapy.

Original languageEnglish
Pages (from-to)7-11
Number of pages5
JournalInternational Journal of Pediatric Hematology/Oncology
Volume7
Issue number1
Publication statusPublished - Jan 1 2000

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Diamond-Blackfan Anemia
Pneumocystis Pneumonia
Chemoprevention
Adrenal Cortex Hormones
Pneumocystis Infections
Tachypnea
Pneumocystis carinii
Bronchoalveolar Lavage Fluid
Endotoxins
Fever
Thorax
X-Rays
Polymerase Chain Reaction
DNA
Therapeutics
Serum

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Cancer Research

Cite this

Pneumocystis carinii pneumonia in Diamond-Blackfan anemia : The necessity of chemoprophylaxis for young infants. / Nomura, A.; Ohga, S.; Asaka, Y.; Takada, H.; Nakao, F.; Kusuhara, K.; Hara, T.

In: International Journal of Pediatric Hematology/Oncology, Vol. 7, No. 1, 01.01.2000, p. 7-11.

Research output: Contribution to journalArticle

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