POK/ZBTB proteins: An emerging family of proteins that regulate lymphoid development and function

Sung Uk Lee, Takahiro Maeda

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

The germinal center (GC) is a unique histological structure found in peripheral lymphoid organs. GCs provide an important source of humoral immunity by generating high affinity antibodies against a pathogen. The GC response is tightly regulated during clonal expansion, immunoglobulin modification, and affinity maturation, whereas its deregulation has a detrimental effect on immune function, leading to development of diseases, such as lymphoma and autoimmunity. LRF (lymphoma/leukemia-related factor), encoded by the ZBTB7A gene, is a transcriptional repressor belonging to the POK (POZ and Krüppel)/ZBTB (zing finger and BTB) protein family. LRF was originally identified as a PLZF (promyelocytic leukemia zinc finger) homolog that physically interacts with BCL6 (B-cell lymphoma 6), whose expression is required for GC formation and associated with non-Hodgkin's lymphoma. Recently, our group demonstrated that LRF plays critical roles in regulating lymphoid lineage commitment, mature B-cell development, and the GC response via distinct mechanisms. Herein, we review POK/ZBTB protein function in lymphoid development, with particular emphasis on the role of LRF in GC B cells.

Original languageEnglish
Pages (from-to)107-119
Number of pages13
JournalImmunological Reviews
Volume247
Issue number1
DOIs
Publication statusPublished - May 1 2012
Externally publishedYes

Fingerprint

Germinal Center
Lymphoma
Leukemia
Proteins
B-Lymphocytes
Antibody Affinity
Zinc Fingers
B-Cell Lymphoma
Humoral Immunity
Autoimmunity
Non-Hodgkin's Lymphoma
Fingers
Immunoglobulins
Genes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

POK/ZBTB proteins : An emerging family of proteins that regulate lymphoid development and function. / Lee, Sung Uk; Maeda, Takahiro.

In: Immunological Reviews, Vol. 247, No. 1, 01.05.2012, p. 107-119.

Research output: Contribution to journalArticle

@article{ba426599ad30422887fbc39f90e118b2,
title = "POK/ZBTB proteins: An emerging family of proteins that regulate lymphoid development and function",
abstract = "The germinal center (GC) is a unique histological structure found in peripheral lymphoid organs. GCs provide an important source of humoral immunity by generating high affinity antibodies against a pathogen. The GC response is tightly regulated during clonal expansion, immunoglobulin modification, and affinity maturation, whereas its deregulation has a detrimental effect on immune function, leading to development of diseases, such as lymphoma and autoimmunity. LRF (lymphoma/leukemia-related factor), encoded by the ZBTB7A gene, is a transcriptional repressor belonging to the POK (POZ and Kr{\"u}ppel)/ZBTB (zing finger and BTB) protein family. LRF was originally identified as a PLZF (promyelocytic leukemia zinc finger) homolog that physically interacts with BCL6 (B-cell lymphoma 6), whose expression is required for GC formation and associated with non-Hodgkin's lymphoma. Recently, our group demonstrated that LRF plays critical roles in regulating lymphoid lineage commitment, mature B-cell development, and the GC response via distinct mechanisms. Herein, we review POK/ZBTB protein function in lymphoid development, with particular emphasis on the role of LRF in GC B cells.",
author = "Lee, {Sung Uk} and Takahiro Maeda",
year = "2012",
month = "5",
day = "1",
doi = "10.1111/j.1600-065X.2012.01116.x",
language = "English",
volume = "247",
pages = "107--119",
journal = "Immunological Reviews",
issn = "0105-2896",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - POK/ZBTB proteins

T2 - An emerging family of proteins that regulate lymphoid development and function

AU - Lee, Sung Uk

AU - Maeda, Takahiro

PY - 2012/5/1

Y1 - 2012/5/1

N2 - The germinal center (GC) is a unique histological structure found in peripheral lymphoid organs. GCs provide an important source of humoral immunity by generating high affinity antibodies against a pathogen. The GC response is tightly regulated during clonal expansion, immunoglobulin modification, and affinity maturation, whereas its deregulation has a detrimental effect on immune function, leading to development of diseases, such as lymphoma and autoimmunity. LRF (lymphoma/leukemia-related factor), encoded by the ZBTB7A gene, is a transcriptional repressor belonging to the POK (POZ and Krüppel)/ZBTB (zing finger and BTB) protein family. LRF was originally identified as a PLZF (promyelocytic leukemia zinc finger) homolog that physically interacts with BCL6 (B-cell lymphoma 6), whose expression is required for GC formation and associated with non-Hodgkin's lymphoma. Recently, our group demonstrated that LRF plays critical roles in regulating lymphoid lineage commitment, mature B-cell development, and the GC response via distinct mechanisms. Herein, we review POK/ZBTB protein function in lymphoid development, with particular emphasis on the role of LRF in GC B cells.

AB - The germinal center (GC) is a unique histological structure found in peripheral lymphoid organs. GCs provide an important source of humoral immunity by generating high affinity antibodies against a pathogen. The GC response is tightly regulated during clonal expansion, immunoglobulin modification, and affinity maturation, whereas its deregulation has a detrimental effect on immune function, leading to development of diseases, such as lymphoma and autoimmunity. LRF (lymphoma/leukemia-related factor), encoded by the ZBTB7A gene, is a transcriptional repressor belonging to the POK (POZ and Krüppel)/ZBTB (zing finger and BTB) protein family. LRF was originally identified as a PLZF (promyelocytic leukemia zinc finger) homolog that physically interacts with BCL6 (B-cell lymphoma 6), whose expression is required for GC formation and associated with non-Hodgkin's lymphoma. Recently, our group demonstrated that LRF plays critical roles in regulating lymphoid lineage commitment, mature B-cell development, and the GC response via distinct mechanisms. Herein, we review POK/ZBTB protein function in lymphoid development, with particular emphasis on the role of LRF in GC B cells.

UR - http://www.scopus.com/inward/record.url?scp=84859709154&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84859709154&partnerID=8YFLogxK

U2 - 10.1111/j.1600-065X.2012.01116.x

DO - 10.1111/j.1600-065X.2012.01116.x

M3 - Article

C2 - 22500835

AN - SCOPUS:84859709154

VL - 247

SP - 107

EP - 119

JO - Immunological Reviews

JF - Immunological Reviews

SN - 0105-2896

IS - 1

ER -