Polyacrylic acid polymer and aldehydes template molecule based MIPs coated QCM sensors for detection of pattern aldehydes in body odor

Sunil K. Jha, Kenshi Hayashi

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Molecularly imprinted polymers (MIPs) have been prepared using the polyacrylic acid (PAA) as host polymer and hexanal, heptanal, and nonanal as pattern molecules. MIPs were employed as selective coating layer of quartz crystal microbalance (QCM) sensors. Hexanal, heptanal, and nonanal were opted as target chemicals after gas chromatography-mass spectrometer (GC-MS) characterization of body odor samples. Transient and static responses of four QCM sensors (three coated with MIPs and one with non-MIP) to target aldehydes in singly, binary and tertiary mixtures, and water at distinct concentrations have been measured. Transient responses were analyzed to compute the response time (ton), and recovery time (toff) of sensors. This result average values of ton ≤ 5 s and toff ≤ 10 s to typical concentrations of target odors. The sensitivity and baseline drift of sensors were also calculated using their static response. The heptanal template molecule based MIP coated QCM exhibit improved sensitivity, reproducibility and faster response, than the rest two MIPs, and non-MIP coated QCMs. Static sensors response matrices were further processed with principal component analysis (PCA) for qualitative (visual) discrimination and support vector machine (SVM) classifier for quantitative recognition (in %) of target aldehydes: in singly, binary and tertiary mixtures. Aldehydes odor was effectively identified in principal component (PC) space. Maximum recognition rate of 89% has been achieved for three classes of binary odors, and 79% for the combination of single, binary and tertiary odor classes in 3-fold cross-validation of SVM classifier.

Original languageEnglish
Pages (from-to)471-487
Number of pages17
JournalSensors and Actuators, B: Chemical
Volume206
DOIs
Publication statusPublished - Jan 1 2015

Fingerprint

carbopol 940
odors
Quartz crystal microbalances
Odors
quartz crystals
Aldehydes
aldehydes
microbalances
Polymers
templates
acids
Molecules
Acids
sensors
Sensors
polymers
molecules
transient response
classifiers
binary mixtures

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

Cite this

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title = "Polyacrylic acid polymer and aldehydes template molecule based MIPs coated QCM sensors for detection of pattern aldehydes in body odor",
abstract = "Molecularly imprinted polymers (MIPs) have been prepared using the polyacrylic acid (PAA) as host polymer and hexanal, heptanal, and nonanal as pattern molecules. MIPs were employed as selective coating layer of quartz crystal microbalance (QCM) sensors. Hexanal, heptanal, and nonanal were opted as target chemicals after gas chromatography-mass spectrometer (GC-MS) characterization of body odor samples. Transient and static responses of four QCM sensors (three coated with MIPs and one with non-MIP) to target aldehydes in singly, binary and tertiary mixtures, and water at distinct concentrations have been measured. Transient responses were analyzed to compute the response time (ton), and recovery time (toff) of sensors. This result average values of ton ≤ 5 s and toff ≤ 10 s to typical concentrations of target odors. The sensitivity and baseline drift of sensors were also calculated using their static response. The heptanal template molecule based MIP coated QCM exhibit improved sensitivity, reproducibility and faster response, than the rest two MIPs, and non-MIP coated QCMs. Static sensors response matrices were further processed with principal component analysis (PCA) for qualitative (visual) discrimination and support vector machine (SVM) classifier for quantitative recognition (in {\%}) of target aldehydes: in singly, binary and tertiary mixtures. Aldehydes odor was effectively identified in principal component (PC) space. Maximum recognition rate of 89{\%} has been achieved for three classes of binary odors, and 79{\%} for the combination of single, binary and tertiary odor classes in 3-fold cross-validation of SVM classifier.",
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AU - Jha, Sunil K.

AU - Hayashi, Kenshi

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N2 - Molecularly imprinted polymers (MIPs) have been prepared using the polyacrylic acid (PAA) as host polymer and hexanal, heptanal, and nonanal as pattern molecules. MIPs were employed as selective coating layer of quartz crystal microbalance (QCM) sensors. Hexanal, heptanal, and nonanal were opted as target chemicals after gas chromatography-mass spectrometer (GC-MS) characterization of body odor samples. Transient and static responses of four QCM sensors (three coated with MIPs and one with non-MIP) to target aldehydes in singly, binary and tertiary mixtures, and water at distinct concentrations have been measured. Transient responses were analyzed to compute the response time (ton), and recovery time (toff) of sensors. This result average values of ton ≤ 5 s and toff ≤ 10 s to typical concentrations of target odors. The sensitivity and baseline drift of sensors were also calculated using their static response. The heptanal template molecule based MIP coated QCM exhibit improved sensitivity, reproducibility and faster response, than the rest two MIPs, and non-MIP coated QCMs. Static sensors response matrices were further processed with principal component analysis (PCA) for qualitative (visual) discrimination and support vector machine (SVM) classifier for quantitative recognition (in %) of target aldehydes: in singly, binary and tertiary mixtures. Aldehydes odor was effectively identified in principal component (PC) space. Maximum recognition rate of 89% has been achieved for three classes of binary odors, and 79% for the combination of single, binary and tertiary odor classes in 3-fold cross-validation of SVM classifier.

AB - Molecularly imprinted polymers (MIPs) have been prepared using the polyacrylic acid (PAA) as host polymer and hexanal, heptanal, and nonanal as pattern molecules. MIPs were employed as selective coating layer of quartz crystal microbalance (QCM) sensors. Hexanal, heptanal, and nonanal were opted as target chemicals after gas chromatography-mass spectrometer (GC-MS) characterization of body odor samples. Transient and static responses of four QCM sensors (three coated with MIPs and one with non-MIP) to target aldehydes in singly, binary and tertiary mixtures, and water at distinct concentrations have been measured. Transient responses were analyzed to compute the response time (ton), and recovery time (toff) of sensors. This result average values of ton ≤ 5 s and toff ≤ 10 s to typical concentrations of target odors. The sensitivity and baseline drift of sensors were also calculated using their static response. The heptanal template molecule based MIP coated QCM exhibit improved sensitivity, reproducibility and faster response, than the rest two MIPs, and non-MIP coated QCMs. Static sensors response matrices were further processed with principal component analysis (PCA) for qualitative (visual) discrimination and support vector machine (SVM) classifier for quantitative recognition (in %) of target aldehydes: in singly, binary and tertiary mixtures. Aldehydes odor was effectively identified in principal component (PC) space. Maximum recognition rate of 89% has been achieved for three classes of binary odors, and 79% for the combination of single, binary and tertiary odor classes in 3-fold cross-validation of SVM classifier.

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