Polybrominated diphenyl ethers from the Indonesian sponge Lamellodysidea herbacea

Novriyandi Hanif, Junichi Tanaka, Andi Setiawan, Agus Trianto, Nicole J. De Voogd, Anggia Murni, Chiaki Tanaka, Tatsuo Higa

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Four new (1-4) and 10 known polybrominated diphenyl ethers (5-14) have been isolated from the title sponge. The structures of the new entities were elucidated by interpretation of spectroscopic data and chemical transformations. These metabolites showed potent antimicrobial activity against Bacillus subtilis and moderate/weak cytotoxicity against NBT-T2 rat bladder epithelial cells. The major constituent 14 was treated under debromination conditions to give eight derivatives, which were subjected to a structure-activity relationship study. The results indicated that the presence of two phenolic hydroxyl groups and bromines at C-2 and/or C-5, as in 2, is important for the exhibition of antibacterial activity.

Original languageEnglish
Pages (from-to)432-435
Number of pages4
JournalJournal of Natural Products
Volume70
Issue number3
DOIs
Publication statusPublished - Mar 1 2007

Fingerprint

Halogenated Diphenyl Ethers
Bromine
Porifera
Bacilli
Structure-Activity Relationship
Cytotoxicity
Metabolites
Bacillus subtilis
Hydroxyl Radical
Rats
Urinary Bladder
Epithelial Cells
Derivatives

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Hanif, N., Tanaka, J., Setiawan, A., Trianto, A., De Voogd, N. J., Murni, A., ... Higa, T. (2007). Polybrominated diphenyl ethers from the Indonesian sponge Lamellodysidea herbacea. Journal of Natural Products, 70(3), 432-435. https://doi.org/10.1021/np0605081

Polybrominated diphenyl ethers from the Indonesian sponge Lamellodysidea herbacea. / Hanif, Novriyandi; Tanaka, Junichi; Setiawan, Andi; Trianto, Agus; De Voogd, Nicole J.; Murni, Anggia; Tanaka, Chiaki; Higa, Tatsuo.

In: Journal of Natural Products, Vol. 70, No. 3, 01.03.2007, p. 432-435.

Research output: Contribution to journalArticle

Hanif, N, Tanaka, J, Setiawan, A, Trianto, A, De Voogd, NJ, Murni, A, Tanaka, C & Higa, T 2007, 'Polybrominated diphenyl ethers from the Indonesian sponge Lamellodysidea herbacea', Journal of Natural Products, vol. 70, no. 3, pp. 432-435. https://doi.org/10.1021/np0605081
Hanif N, Tanaka J, Setiawan A, Trianto A, De Voogd NJ, Murni A et al. Polybrominated diphenyl ethers from the Indonesian sponge Lamellodysidea herbacea. Journal of Natural Products. 2007 Mar 1;70(3):432-435. https://doi.org/10.1021/np0605081
Hanif, Novriyandi ; Tanaka, Junichi ; Setiawan, Andi ; Trianto, Agus ; De Voogd, Nicole J. ; Murni, Anggia ; Tanaka, Chiaki ; Higa, Tatsuo. / Polybrominated diphenyl ethers from the Indonesian sponge Lamellodysidea herbacea. In: Journal of Natural Products. 2007 ; Vol. 70, No. 3. pp. 432-435.
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