Polybrominated diphenyl ethers from the Indonesian sponge Lamellodysidea herbacea

Novriyandi Hanif, Junichi Tanaka, Andi Setiawan, Agus Trianto, Nicole J. De Voogd, Anggia Murni, Chiaki Tanaka, Tatsuo Higa

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35 Citations (Scopus)

Abstract

Four new (1-4) and 10 known polybrominated diphenyl ethers (5-14) have been isolated from the title sponge. The structures of the new entities were elucidated by interpretation of spectroscopic data and chemical transformations. These metabolites showed potent antimicrobial activity against Bacillus subtilis and moderate/weak cytotoxicity against NBT-T2 rat bladder epithelial cells. The major constituent 14 was treated under debromination conditions to give eight derivatives, which were subjected to a structure-activity relationship study. The results indicated that the presence of two phenolic hydroxyl groups and bromines at C-2 and/or C-5, as in 2, is important for the exhibition of antibacterial activity.

Original languageEnglish
Pages (from-to)432-435
Number of pages4
JournalJournal of Natural Products
Volume70
Issue number3
DOIs
Publication statusPublished - Mar 1 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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  • Cite this

    Hanif, N., Tanaka, J., Setiawan, A., Trianto, A., De Voogd, N. J., Murni, A., Tanaka, C., & Higa, T. (2007). Polybrominated diphenyl ethers from the Indonesian sponge Lamellodysidea herbacea. Journal of Natural Products, 70(3), 432-435. https://doi.org/10.1021/np0605081