Polycomb Group Proteins Regulate Chromatin Architecture in Mouse Oocytes and Early Embryos

Zhenhai Du, Hui Zheng, Yumiko K. Kawamura, Ke Zhang, Johanna Gassler, Sean Powell, Qianhua Xu, Zili Lin, Kai Xu, Qian Zhou, Evgeniy A. Ozonov, Nathalie Véron, Bo Huang, Lijia Li, Guang Yu, Ling Liu, Wan Kin Au Yeung, Peizhe Wang, Lei Chang, Qiujun WangAibin He, Yujie Sun, Jie Na, Qingyuan Sun, Hiroyuki Sasaki, Kikuë Tachibana, Antoine H.F.M. Peters, Wei Xie

Research output: Contribution to journalArticle

Abstract

In mammals, germ cells undergo a series of events to give rise to haploid gametes. The dynamics of meiotic chromatin architecture still remain poorly understood. By applying Hi-C to mouse oocytes, Du et al. reveal a unique Polycomb-regulated chromatin architecture, which adds a new perspective to the non-canonical oocyte epigenomes.

Original languageEnglish
Pages (from-to)825-839.e7
JournalMolecular Cell
Volume77
Issue number4
DOIs
Publication statusPublished - Feb 20 2020

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All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

Cite this

Du, Z., Zheng, H., Kawamura, Y. K., Zhang, K., Gassler, J., Powell, S., ... Xie, W. (2020). Polycomb Group Proteins Regulate Chromatin Architecture in Mouse Oocytes and Early Embryos. Molecular Cell, 77(4), 825-839.e7. https://doi.org/10.1016/j.molcel.2019.11.011