Polycomb Group Proteins Regulate Chromatin Architecture in Mouse Oocytes and Early Embryos

Zhenhai Du; Hui Zheng; Yumiko K. Kawamura; Ke Zhang; Johanna Gassler; Sean Powell; Qianhua Xu; Zili Lin; Kai Xu; Qian Zhou; Evgeniy A. Ozonov; Nathalie Véron; Bo Huang; Lijia Li; Guang Yu; Ling Liu; Wan Kin Au Yeung; Peizhe Wang; Lei Chang; Qiujun Wang; Aibin He; Yujie Sun; Jie Na; Qingyuan Sun; Hiroyuki Sasaki; Kikuë Tachibana; Antoine H.F.M. Peters; Wei Xie

doi:10.1016/j.molcel.2019.11.011

Polycomb Group Proteins Regulate Chromatin Architecture in Mouse Oocytes and Early Embryos

Zhenhai Du, Hui Zheng, Yumiko K. Kawamura, Ke Zhang, Johanna Gassler, Sean Powell, Qianhua Xu, Zili Lin, Kai Xu, Qian Zhou, Evgeniy A. Ozonov, Nathalie Véron, Bo Huang, Lijia Li, Guang Yu, Ling Liu, Wan Kin Au Yeung, Peizhe Wang, Lei Chang, Qiujun WangAibin He, Yujie Sun, Jie Na, Qingyuan Sun, Hiroyuki Sasaki, Kikuë Tachibana, Antoine H.F.M. Peters, Wei Xie

Department of Molecular and Structural Biology

Research output: Contribution to journal › Article

Abstract

In mammals, germ cells undergo a series of events to give rise to haploid gametes. The dynamics of meiotic chromatin architecture still remain poorly understood. By applying Hi-C to mouse oocytes, Du et al. reveal a unique Polycomb-regulated chromatin architecture, which adds a new perspective to the non-canonical oocyte epigenomes.

Original language	English
Pages (from-to)	825-839.e7
Journal	Molecular Cell
Volume	77
Issue number	4
DOIs	https://doi.org/10.1016/j.molcel.2019.11.011
Publication status	Published - Feb 20 2020

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All Science Journal Classification (ASJC) codes

Molecular Biology
Cell Biology

Cite this

Du, Z., Zheng, H., Kawamura, Y. K., Zhang, K., Gassler, J., Powell, S., ... Xie, W. (2020). Polycomb Group Proteins Regulate Chromatin Architecture in Mouse Oocytes and Early Embryos. Molecular Cell, 77(4), 825-839.e7. https://doi.org/10.1016/j.molcel.2019.11.011

Polycomb Group Proteins Regulate Chromatin Architecture in Mouse Oocytes and Early Embryos. / Du, Zhenhai; Zheng, Hui; Kawamura, Yumiko K.; Zhang, Ke; Gassler, Johanna; Powell, Sean; Xu, Qianhua; Lin, Zili; Xu, Kai; Zhou, Qian; Ozonov, Evgeniy A.; Véron, Nathalie; Huang, Bo; Li, Lijia; Yu, Guang; Liu, Ling; Au Yeung, Wan Kin; Wang, Peizhe; Chang, Lei; Wang, Qiujun; He, Aibin; Sun, Yujie; Na, Jie; Sun, Qingyuan; Sasaki, Hiroyuki; Tachibana, Kikuë; Peters, Antoine H.F.M.; Xie, Wei.

In: Molecular Cell, Vol. 77, No. 4, 20.02.2020, p. 825-839.e7.

Research output: Contribution to journal › Article

Du, Z, Zheng, H, Kawamura, YK, Zhang, K, Gassler, J, Powell, S, Xu, Q, Lin, Z, Xu, K, Zhou, Q, Ozonov, EA, Véron, N, Huang, B, Li, L, Yu, G, Liu, L, Au Yeung, WK, Wang, P, Chang, L, Wang, Q, He, A, Sun, Y, Na, J, Sun, Q, Sasaki, H, Tachibana, K, Peters, AHFM & Xie, W 2020, 'Polycomb Group Proteins Regulate Chromatin Architecture in Mouse Oocytes and Early Embryos', Molecular Cell, vol. 77, no. 4, pp. 825-839.e7. https://doi.org/10.1016/j.molcel.2019.11.011

Du, Zhenhai ; Zheng, Hui ; Kawamura, Yumiko K. ; Zhang, Ke ; Gassler, Johanna ; Powell, Sean ; Xu, Qianhua ; Lin, Zili ; Xu, Kai ; Zhou, Qian ; Ozonov, Evgeniy A. ; Véron, Nathalie ; Huang, Bo ; Li, Lijia ; Yu, Guang ; Liu, Ling ; Au Yeung, Wan Kin ; Wang, Peizhe ; Chang, Lei ; Wang, Qiujun ; He, Aibin ; Sun, Yujie ; Na, Jie ; Sun, Qingyuan ; Sasaki, Hiroyuki ; Tachibana, Kikuë ; Peters, Antoine H.F.M. ; Xie, Wei. / Polycomb Group Proteins Regulate Chromatin Architecture in Mouse Oocytes and Early Embryos. In: Molecular Cell. 2020 ; Vol. 77, No. 4. pp. 825-839.e7.

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10.1016/j.molcel.2019.11.011