TY - JOUR
T1 - Poly(ethylene glycol)-modified gold nanorods as a photothermal nanodevice for hyperthermia
AU - Niidome, Takuro
AU - Akiyama, Yasuyuki
AU - Yamagata, Masato
AU - Kawano, Takahito
AU - Mori, Takeshi
AU - Niidome, Yasuro
AU - Katayama, Yoshiki
N1 - Funding Information:
This research was supported by a Grant-in-Aid for Exploratory Research (No. 18650124) and a Grant-in-Aid for Scientific Research (B) (No. 19300172) from the Japan Society for the Promotion of Science (JSPS), a Grant-in-Aid for Scientific Research in the Priority Area “Molecular Nano Dynamics” (No. 17034049) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) and a Grant-in-Aid from PRESTO, Japan Science and Technology Corporation.
PY - 2009/5/1
Y1 - 2009/5/1
N2 - Gold nanorods, which have a strong surface plasmon band at the near-infrared region, absorb light energy which is then converted to heat. Since near-infrared light can penetrate deeply into tissue, gold nanorods are expected to be useful as photosensitizers for photothermal therapy. In this study, the length of the poly(ethylene glycol) (PEG) chain was optimized in order to stabilize the gold nanorods in the blood circulation after intravenous injection. PEG5000- and PEG10000-modified gold nanorods showed higher stability in the blood circulation compared with PEG 2000- and PEG20000-modified gold nanorods. As a demonstration of photothermal tissue damage, PEG5000-modified gold nanorods were injected into the muscle in the hind limbs of a mouse, and then irradiated with near-infrared pulsed laser light. Significant tissue damage was observed only in the presence of gold nanorods and laser irradiation. We next injected the gold nanorods directly into subcutaneous tumors in mice, and then irradiated the tumor with near-infrared pulsed laser light. Significant suppression of tumor growth was observed. In the case of the intravenous injection of gold nanorods, the suppression of tumor growth was weaker than for the case of direct injection, indicating that the targeted delivery of gold nanorods to the tumor tissue is an important key to improve the therapeutic effect.
AB - Gold nanorods, which have a strong surface plasmon band at the near-infrared region, absorb light energy which is then converted to heat. Since near-infrared light can penetrate deeply into tissue, gold nanorods are expected to be useful as photosensitizers for photothermal therapy. In this study, the length of the poly(ethylene glycol) (PEG) chain was optimized in order to stabilize the gold nanorods in the blood circulation after intravenous injection. PEG5000- and PEG10000-modified gold nanorods showed higher stability in the blood circulation compared with PEG 2000- and PEG20000-modified gold nanorods. As a demonstration of photothermal tissue damage, PEG5000-modified gold nanorods were injected into the muscle in the hind limbs of a mouse, and then irradiated with near-infrared pulsed laser light. Significant tissue damage was observed only in the presence of gold nanorods and laser irradiation. We next injected the gold nanorods directly into subcutaneous tumors in mice, and then irradiated the tumor with near-infrared pulsed laser light. Significant suppression of tumor growth was observed. In the case of the intravenous injection of gold nanorods, the suppression of tumor growth was weaker than for the case of direct injection, indicating that the targeted delivery of gold nanorods to the tumor tissue is an important key to improve the therapeutic effect.
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U2 - 10.1163/156856209X452953
DO - 10.1163/156856209X452953
M3 - Article
C2 - 19520008
AN - SCOPUS:67650296969
SN - 0920-5063
VL - 20
SP - 1203
EP - 1215
JO - Journal of Biomaterials Science, Polymer Edition
JF - Journal of Biomaterials Science, Polymer Edition
IS - 9
ER -