Polylactic acid for visualizing the vitreous body during vitrectomy

Toshifumi Yamashita, Taiji Sakamoto, Keita Yamakiri, Muneki Miura, Hiroshi Enaida, Akifumi Ueno, Ikuyo Atsumi, Keucht Matsuhisa, Yuji Sakamoto, Tetsuo Kida, Tatsuro Ishibashi

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

PURPOSE. To investigate the possibility of using polylactic acid (PLA) as a surgical adjuvant for visualizing the vitreous body during vitrectomy. METHODS. After a core vitrectomy, 1 mL of PLA suspension was injected into the rabbit vitreous in two groups: group A, 2.5% PLA (n = 5), and group B, 1% PLA (n = 9). Vehicle injection instead of PLA was used as a control (group C, n = 5). The clinical signs and electroretinogram (ERG) were evaluated for 28 days, and histologic findings were evaluated on day 28. Next, intraocular pressure (JOP) after intracameral injection of a PLA suspension was evaluated in the rabbits (n = 6). Last, the visualization of the vitreous body by PLA suspension was evaluated during vitrectomy in monkey eyes (n = 4). RESULTS. The white granules of PLA disappeared from the vitreous cavity in 10 eyes within 3 weeks; however, a small amount of PLA remained in four eyes for 4 weeks. Mild inflammation of the anterior chamber was observed in one eye in group B and 1 eye in group C. No cataract or retinal hemorrhage was found in any eyes. The amplitude of ERG on each time point did not differ between the groups. IOP remained within normal range except for the initial spike. Retinal structure was well preserved histologically. During vitrectomy in monkey eyes, the vitreous body was well visualized, and the posterior vitreous separation was performed easily and safely. CONCLUSIONS. PLA can be a new surgical adjuvant to visualize the vitreous body during vitrectomy.

Original languageEnglish
Pages (from-to)3277-3282
Number of pages6
JournalInvestigative Ophthalmology and Visual Science
Volume48
Issue number7
DOIs
Publication statusPublished - Jul 2007

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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