Polymer-coated carbon nanotubes as a molecular heater platform for hyperthermic therapy

Koichiro Mori, Minoru Kawaguchi, Tsuyohiko Fujigaya, Jun Ohno, Tetsuro Ikebe

Research output: Contribution to journalArticle

Abstract

Carbon nanotubes have been explored as heat-delivery vehicles for thermal ablation of tumors. To use single-walled carbon nanotubes (SWNT) as a “molecular heater” for hyperthermic therapy in cancer treatment, stable dispersibility and smart-targeting potential are necessary. The current study reports the dispersibility and exothermic properties with near-infrared (NIR) exposure for SWNT coated with a copolymer of N-isopropylacrylamide and polyethyleneglycol methacrylate (SWNT/PNIPAM-PEG-hybrid). The SWNT/PNIPAM-PEG hybrid showed stable dispersibility in PBS solution and exothermic potential with NIR exposure. Raman spectroscopy results revealed a hybrid derived Raman peak in mouse liver and spleen lysates for 7 days post-injection that disappeared by 14 days in all tissues (liver, spleen, heart, lung and kidney). These results suggested that the hybrid did not accumulate in mouse organ tissues in the long-term. The SWNT/PNIPAM-PEG hybrid decreased the cell viability (of mouse macrophages) with heat generation by NIR exposure. The results of this study demonstrate that the SWNT/PNIPAM-PEG hybrid is a useful platform for a “molecular heater” applicable to hyperthermic cancer therapy.

Original languageEnglish
Pages (from-to)139-146
Number of pages8
JournalJournal of Hard Tissue Biology
Volume27
Issue number2
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Carbon Nanotubes
Single-walled carbon nanotubes (SWCN)
Carbon nanotubes
Polymers
Polyethylene glycols
Infrared radiation
Hot Temperature
Liver
Therapeutics
Tissue
Spleen
Oncology
Methacrylates
Macrophages
Heat generation
Neoplasms
Ablation
Raman Spectrum Analysis
Hybrid Cells
Raman spectroscopy

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Biochemistry
  • Biomaterials
  • Orthopedics and Sports Medicine
  • Dentistry(all)
  • Cell Biology

Cite this

Polymer-coated carbon nanotubes as a molecular heater platform for hyperthermic therapy. / Mori, Koichiro; Kawaguchi, Minoru; Fujigaya, Tsuyohiko; Ohno, Jun; Ikebe, Tetsuro.

In: Journal of Hard Tissue Biology, Vol. 27, No. 2, 01.01.2018, p. 139-146.

Research output: Contribution to journalArticle

Mori, Koichiro ; Kawaguchi, Minoru ; Fujigaya, Tsuyohiko ; Ohno, Jun ; Ikebe, Tetsuro. / Polymer-coated carbon nanotubes as a molecular heater platform for hyperthermic therapy. In: Journal of Hard Tissue Biology. 2018 ; Vol. 27, No. 2. pp. 139-146.
@article{a93b982223544387872b67836a72158a,
title = "Polymer-coated carbon nanotubes as a molecular heater platform for hyperthermic therapy",
abstract = "Carbon nanotubes have been explored as heat-delivery vehicles for thermal ablation of tumors. To use single-walled carbon nanotubes (SWNT) as a “molecular heater” for hyperthermic therapy in cancer treatment, stable dispersibility and smart-targeting potential are necessary. The current study reports the dispersibility and exothermic properties with near-infrared (NIR) exposure for SWNT coated with a copolymer of N-isopropylacrylamide and polyethyleneglycol methacrylate (SWNT/PNIPAM-PEG-hybrid). The SWNT/PNIPAM-PEG hybrid showed stable dispersibility in PBS solution and exothermic potential with NIR exposure. Raman spectroscopy results revealed a hybrid derived Raman peak in mouse liver and spleen lysates for 7 days post-injection that disappeared by 14 days in all tissues (liver, spleen, heart, lung and kidney). These results suggested that the hybrid did not accumulate in mouse organ tissues in the long-term. The SWNT/PNIPAM-PEG hybrid decreased the cell viability (of mouse macrophages) with heat generation by NIR exposure. The results of this study demonstrate that the SWNT/PNIPAM-PEG hybrid is a useful platform for a “molecular heater” applicable to hyperthermic cancer therapy.",
author = "Koichiro Mori and Minoru Kawaguchi and Tsuyohiko Fujigaya and Jun Ohno and Tetsuro Ikebe",
year = "2018",
month = "1",
day = "1",
doi = "10.2485/jhtb.27.139",
language = "English",
volume = "27",
pages = "139--146",
journal = "Journal of Hard Tissue Biology",
issn = "1341-7649",
publisher = "Society of Hard Tissue Regenerative Biology",
number = "2",

}

TY - JOUR

T1 - Polymer-coated carbon nanotubes as a molecular heater platform for hyperthermic therapy

AU - Mori, Koichiro

AU - Kawaguchi, Minoru

AU - Fujigaya, Tsuyohiko

AU - Ohno, Jun

AU - Ikebe, Tetsuro

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Carbon nanotubes have been explored as heat-delivery vehicles for thermal ablation of tumors. To use single-walled carbon nanotubes (SWNT) as a “molecular heater” for hyperthermic therapy in cancer treatment, stable dispersibility and smart-targeting potential are necessary. The current study reports the dispersibility and exothermic properties with near-infrared (NIR) exposure for SWNT coated with a copolymer of N-isopropylacrylamide and polyethyleneglycol methacrylate (SWNT/PNIPAM-PEG-hybrid). The SWNT/PNIPAM-PEG hybrid showed stable dispersibility in PBS solution and exothermic potential with NIR exposure. Raman spectroscopy results revealed a hybrid derived Raman peak in mouse liver and spleen lysates for 7 days post-injection that disappeared by 14 days in all tissues (liver, spleen, heart, lung and kidney). These results suggested that the hybrid did not accumulate in mouse organ tissues in the long-term. The SWNT/PNIPAM-PEG hybrid decreased the cell viability (of mouse macrophages) with heat generation by NIR exposure. The results of this study demonstrate that the SWNT/PNIPAM-PEG hybrid is a useful platform for a “molecular heater” applicable to hyperthermic cancer therapy.

AB - Carbon nanotubes have been explored as heat-delivery vehicles for thermal ablation of tumors. To use single-walled carbon nanotubes (SWNT) as a “molecular heater” for hyperthermic therapy in cancer treatment, stable dispersibility and smart-targeting potential are necessary. The current study reports the dispersibility and exothermic properties with near-infrared (NIR) exposure for SWNT coated with a copolymer of N-isopropylacrylamide and polyethyleneglycol methacrylate (SWNT/PNIPAM-PEG-hybrid). The SWNT/PNIPAM-PEG hybrid showed stable dispersibility in PBS solution and exothermic potential with NIR exposure. Raman spectroscopy results revealed a hybrid derived Raman peak in mouse liver and spleen lysates for 7 days post-injection that disappeared by 14 days in all tissues (liver, spleen, heart, lung and kidney). These results suggested that the hybrid did not accumulate in mouse organ tissues in the long-term. The SWNT/PNIPAM-PEG hybrid decreased the cell viability (of mouse macrophages) with heat generation by NIR exposure. The results of this study demonstrate that the SWNT/PNIPAM-PEG hybrid is a useful platform for a “molecular heater” applicable to hyperthermic cancer therapy.

UR - http://www.scopus.com/inward/record.url?scp=85045121648&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85045121648&partnerID=8YFLogxK

U2 - 10.2485/jhtb.27.139

DO - 10.2485/jhtb.27.139

M3 - Article

AN - SCOPUS:85045121648

VL - 27

SP - 139

EP - 146

JO - Journal of Hard Tissue Biology

JF - Journal of Hard Tissue Biology

SN - 1341-7649

IS - 2

ER -