Polymerization of diacetylene in casting parallel and anti-parallel β-sheet

Shiro Yasutake, Takeshi Mori, Keiji Minagawa, Masami Tanaka

Research output: Chapter in Book/Report/Conference proceedingConference contribution


In the β sheet structure of the peptide, the distance among the β-strands are 5 Å. This distance corresponds with distance among the monomer units of diacetylene and diene. Therefore the β-sheet will be able to be cross-linked by introducing these monomer units into the diacetylene and diene into peptide that formed β-sheet by using this. In this work, we synthesized peptide 1-4. Peptide 1 and 2 were design to form anti-parallel β-sheet alone. On the other hand, peptide 3 and 4 were design to form parallel β-sheet by mixing them. Polymerization of 1 and 2 was conducted by UV irradiation. After the polymerization, UV-vis spectra of 1 and 2 in dichloroacetic acid had an absorbance at 573 nm that originates in poly diacetylene. The result of FT-IR measurement of them showed disappearance of a peak at 2250 cm-1 that originates in diacetylene. Amide I region suggested that the peptides formed anti-parallel β-sheet and random coil. Therefore, it seemed that polymerization occurred in the β-sheet formed part.

Original languageEnglish
Title of host publication54th SPSJ Annual Meeting 2005 - Polymer Preprints, Japan
Number of pages1
Publication statusPublished - 2005
Externally publishedYes
Event54th SPSJ Annual Meeting 2005 - Yokohama, Japan
Duration: May 25 2005May 27 2005


Other54th SPSJ Annual Meeting 2005

All Science Journal Classification (ASJC) codes

  • Engineering(all)


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