Polymorphism of MDR1 Gene in Healthy Japanese Subjects: A Novel SNP with an Amino Acid Substitution (Glu108Lys)

Tomohiro Honda, Yukihiko Dan, Noriko Koyabu, Hisakazu Ohtani, Yasufumi Sawada, Ichiro Ieiri, Kenji Otsubo, Shun Higuchi

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Abstract

We discovered a novel single nucleotide polymorphism (SNP) at position 325 (G325A) in exon 5 of the multidrug-resistance 1 (MDR1) gene in a study of 37 healthy Japanese subjects. Details are as follows. SNP, 020614Honda001; GENE NAME, human P-glycoprotein (MDR1); ACCESSION NUMBER, M29427; LENGTH, 25 bases; 5' -ATGAATCTGGAGG/AAAGACATGACCA-3'. This SNP is expected to cause an amino acid substitution (Glu108Lys). In this study, one homozygote and one heterozygote for G325A were identified.

Original languageEnglish
Pages (from-to)479-481
Number of pages3
JournalDrug metabolism and pharmacokinetics
Volume17
Issue number5
DOIs
Publication statusPublished - Jan 1 2002
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Pharmacology (medical)

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