Polymorphisms in ADAM33 are associated with allergic rhinitis due to Japanese cedar pollen

L. Cheng, T. Enomoto, T. Hirota, M. Shimizu, N. Takahashi, Mitsuteru Akahoshi, A. Matsuda, Y. Dake, S. Doi, K. Enomoto, A. Yamasaki, S. Fukuda, X. Q. Mao, J. M. Hopkin, M. Tamari, T. Shirakawa

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Abstract

Background: A recent report provided evidence that a disintegrin and metalloprotease domain 33 (ADAM33), a member of the ADAM family, is a novel susceptibility gene in asthma linked to bronchial hyper-responsiveness. However, there has been no investigation of the genetic role of ADAM33 variants in nasal allergy. Objective: The purpose of this study was to test the association between ADAM33 polymorphisms and Japanese cedar pollinosis (JCPsis), a most common seasonal allergic rhinitis in Japan. Methods: We conducted a case-control association study among a Japanese population, involving 95 adult individuals with JCPsis and 95 normal healthy controls. A total of 22 single-nucleotide polymorphisms (SNPs) in ADAM33 were genotyped using PCR-based molecular methods. Results: Six SNPs of ADAM33 gene, three in introns (7575G/A, 9073G/A and 12540C/T) and three in the coding region (10918G/C, 12433T/C and 12462C/T), were strongly associated with JCPsis (P = 0.0002-0.022 for absolute allele frequencies) and most of the SNPs were in linkage disequilibrium with each other. A higher frequency of the common alleles of these SNPs was noted for the subjects with JCPsis in comparison with healthy controls. We also identified a haplotype associated with the disease susceptibility. In addition, associations were found between ADAM33 polymorphisms and various cedar pollinosis phenotypes including clinical severity, eosinophil counts in nasal secretion and allergen-specific IgE levels in sera, but not total serum IgE levels. Conclusion: These results indicate that polymorphisms in the ADAM33 gene are associated with susceptibility to allergic rhinitis due to Japanese cedar pollen, but the functional relationship still needs clarification.

Original languageEnglish
Pages (from-to)1192-1201
Number of pages10
JournalClinical and Experimental Allergy
Volume34
Issue number8
DOIs
Publication statusPublished - Aug 1 2004
Externally publishedYes

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Cryptomeria
Disintegrins
Metalloproteases
Pollen
Seasonal Allergic Rhinitis
Single Nucleotide Polymorphism
Nose
Gene Frequency
Immunoglobulin E
Genes
Disease Susceptibility
Linkage Disequilibrium
Allergic Rhinitis
Serum
Eosinophils
Allergens
Introns
Haplotypes
Case-Control Studies
Japan

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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Polymorphisms in ADAM33 are associated with allergic rhinitis due to Japanese cedar pollen. / Cheng, L.; Enomoto, T.; Hirota, T.; Shimizu, M.; Takahashi, N.; Akahoshi, Mitsuteru; Matsuda, A.; Dake, Y.; Doi, S.; Enomoto, K.; Yamasaki, A.; Fukuda, S.; Mao, X. Q.; Hopkin, J. M.; Tamari, M.; Shirakawa, T.

In: Clinical and Experimental Allergy, Vol. 34, No. 8, 01.08.2004, p. 1192-1201.

Research output: Contribution to journalArticle

Cheng, L, Enomoto, T, Hirota, T, Shimizu, M, Takahashi, N, Akahoshi, M, Matsuda, A, Dake, Y, Doi, S, Enomoto, K, Yamasaki, A, Fukuda, S, Mao, XQ, Hopkin, JM, Tamari, M & Shirakawa, T 2004, 'Polymorphisms in ADAM33 are associated with allergic rhinitis due to Japanese cedar pollen', Clinical and Experimental Allergy, vol. 34, no. 8, pp. 1192-1201. https://doi.org/10.1111/j.1365-2222.2004.02008.x
Cheng, L. ; Enomoto, T. ; Hirota, T. ; Shimizu, M. ; Takahashi, N. ; Akahoshi, Mitsuteru ; Matsuda, A. ; Dake, Y. ; Doi, S. ; Enomoto, K. ; Yamasaki, A. ; Fukuda, S. ; Mao, X. Q. ; Hopkin, J. M. ; Tamari, M. ; Shirakawa, T. / Polymorphisms in ADAM33 are associated with allergic rhinitis due to Japanese cedar pollen. In: Clinical and Experimental Allergy. 2004 ; Vol. 34, No. 8. pp. 1192-1201.
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abstract = "Background: A recent report provided evidence that a disintegrin and metalloprotease domain 33 (ADAM33), a member of the ADAM family, is a novel susceptibility gene in asthma linked to bronchial hyper-responsiveness. However, there has been no investigation of the genetic role of ADAM33 variants in nasal allergy. Objective: The purpose of this study was to test the association between ADAM33 polymorphisms and Japanese cedar pollinosis (JCPsis), a most common seasonal allergic rhinitis in Japan. Methods: We conducted a case-control association study among a Japanese population, involving 95 adult individuals with JCPsis and 95 normal healthy controls. A total of 22 single-nucleotide polymorphisms (SNPs) in ADAM33 were genotyped using PCR-based molecular methods. Results: Six SNPs of ADAM33 gene, three in introns (7575G/A, 9073G/A and 12540C/T) and three in the coding region (10918G/C, 12433T/C and 12462C/T), were strongly associated with JCPsis (P = 0.0002-0.022 for absolute allele frequencies) and most of the SNPs were in linkage disequilibrium with each other. A higher frequency of the common alleles of these SNPs was noted for the subjects with JCPsis in comparison with healthy controls. We also identified a haplotype associated with the disease susceptibility. In addition, associations were found between ADAM33 polymorphisms and various cedar pollinosis phenotypes including clinical severity, eosinophil counts in nasal secretion and allergen-specific IgE levels in sera, but not total serum IgE levels. Conclusion: These results indicate that polymorphisms in the ADAM33 gene are associated with susceptibility to allergic rhinitis due to Japanese cedar pollen, but the functional relationship still needs clarification.",
author = "L. Cheng and T. Enomoto and T. Hirota and M. Shimizu and N. Takahashi and Mitsuteru Akahoshi and A. Matsuda and Y. Dake and S. Doi and K. Enomoto and A. Yamasaki and S. Fukuda and Mao, {X. Q.} and Hopkin, {J. M.} and M. Tamari and T. Shirakawa",
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T1 - Polymorphisms in ADAM33 are associated with allergic rhinitis due to Japanese cedar pollen

AU - Cheng, L.

AU - Enomoto, T.

AU - Hirota, T.

AU - Shimizu, M.

AU - Takahashi, N.

AU - Akahoshi, Mitsuteru

AU - Matsuda, A.

AU - Dake, Y.

AU - Doi, S.

AU - Enomoto, K.

AU - Yamasaki, A.

AU - Fukuda, S.

AU - Mao, X. Q.

AU - Hopkin, J. M.

AU - Tamari, M.

AU - Shirakawa, T.

PY - 2004/8/1

Y1 - 2004/8/1

N2 - Background: A recent report provided evidence that a disintegrin and metalloprotease domain 33 (ADAM33), a member of the ADAM family, is a novel susceptibility gene in asthma linked to bronchial hyper-responsiveness. However, there has been no investigation of the genetic role of ADAM33 variants in nasal allergy. Objective: The purpose of this study was to test the association between ADAM33 polymorphisms and Japanese cedar pollinosis (JCPsis), a most common seasonal allergic rhinitis in Japan. Methods: We conducted a case-control association study among a Japanese population, involving 95 adult individuals with JCPsis and 95 normal healthy controls. A total of 22 single-nucleotide polymorphisms (SNPs) in ADAM33 were genotyped using PCR-based molecular methods. Results: Six SNPs of ADAM33 gene, three in introns (7575G/A, 9073G/A and 12540C/T) and three in the coding region (10918G/C, 12433T/C and 12462C/T), were strongly associated with JCPsis (P = 0.0002-0.022 for absolute allele frequencies) and most of the SNPs were in linkage disequilibrium with each other. A higher frequency of the common alleles of these SNPs was noted for the subjects with JCPsis in comparison with healthy controls. We also identified a haplotype associated with the disease susceptibility. In addition, associations were found between ADAM33 polymorphisms and various cedar pollinosis phenotypes including clinical severity, eosinophil counts in nasal secretion and allergen-specific IgE levels in sera, but not total serum IgE levels. Conclusion: These results indicate that polymorphisms in the ADAM33 gene are associated with susceptibility to allergic rhinitis due to Japanese cedar pollen, but the functional relationship still needs clarification.

AB - Background: A recent report provided evidence that a disintegrin and metalloprotease domain 33 (ADAM33), a member of the ADAM family, is a novel susceptibility gene in asthma linked to bronchial hyper-responsiveness. However, there has been no investigation of the genetic role of ADAM33 variants in nasal allergy. Objective: The purpose of this study was to test the association between ADAM33 polymorphisms and Japanese cedar pollinosis (JCPsis), a most common seasonal allergic rhinitis in Japan. Methods: We conducted a case-control association study among a Japanese population, involving 95 adult individuals with JCPsis and 95 normal healthy controls. A total of 22 single-nucleotide polymorphisms (SNPs) in ADAM33 were genotyped using PCR-based molecular methods. Results: Six SNPs of ADAM33 gene, three in introns (7575G/A, 9073G/A and 12540C/T) and three in the coding region (10918G/C, 12433T/C and 12462C/T), were strongly associated with JCPsis (P = 0.0002-0.022 for absolute allele frequencies) and most of the SNPs were in linkage disequilibrium with each other. A higher frequency of the common alleles of these SNPs was noted for the subjects with JCPsis in comparison with healthy controls. We also identified a haplotype associated with the disease susceptibility. In addition, associations were found between ADAM33 polymorphisms and various cedar pollinosis phenotypes including clinical severity, eosinophil counts in nasal secretion and allergen-specific IgE levels in sera, but not total serum IgE levels. Conclusion: These results indicate that polymorphisms in the ADAM33 gene are associated with susceptibility to allergic rhinitis due to Japanese cedar pollen, but the functional relationship still needs clarification.

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