TY - JOUR
T1 - Polymorphisms in PPAR genes (PPARD, PPARG, and PPARGC1A) and the risk of chronic kidney disease in Japanese
T2 - Cross-sectional data from the J-MICC study
AU - Hishida, Asahi
AU - Wakai, Kenji
AU - Naito, Mariko
AU - Tamura, Takashi
AU - Kawai, Sayo
AU - Hamajima, Nobuyuki
AU - Oze, Isao
AU - Imaizumi, Takeshi
AU - Turin, Tanvir Chowdhury
AU - Suzuki, Sadao
AU - Kheradmand, Motahare
AU - Mikami, Haruo
AU - Ohnaka, Keizo
AU - Watanabe, Yoshiyuki
AU - Arisawa, Kokichi
AU - Kubo, Michiaki
AU - Tanaka, Hideo
PY - 2013
Y1 - 2013
N2 - Chronic kidney disease (CKD) is well known as a strong risk factor for both end stage renal disease and cardiovascular disease. To clarify the association of polymorphisms in the PPAR genes (PPARD, PPARG, and PPARGC1A) with the risk of CKD in Japanese, we examined this association among the Japanese subjects using the cross-sectional data of J-MICC (Japan Multi-Institutional Collaborative Cohort) Study. The subjects for this analysis were 3,285 men and women, aged 35-69 years, selected from J-MICC Study participants; genotyping was conducted by multiplex polymerase chain reaction-based Invader assay. The prevalence of CKD was determined for CKD stages 3-5 (defined as eGFR < 60 ml/min/1.73 m2). Participants with CKD accounted for 17.3% of the study population. When those with PPARD T-842C T/T were defined as reference, those with PPARD T-842C T/C and C/C demonstrated the OR for CKD of 1.26 (95%CI 1.04-1.53) and 1.31 (95%CI 0.83-2.06), respectively. There were no significant associations between the polymorphisms in other PPAR genes and the risk of CKD. The present study found a significantly increased risk of CKD in those with the C allele of PPARD T-842C, which may suggest the possibility of personalized risk estimation of this life-limiting disease in the near future.
AB - Chronic kidney disease (CKD) is well known as a strong risk factor for both end stage renal disease and cardiovascular disease. To clarify the association of polymorphisms in the PPAR genes (PPARD, PPARG, and PPARGC1A) with the risk of CKD in Japanese, we examined this association among the Japanese subjects using the cross-sectional data of J-MICC (Japan Multi-Institutional Collaborative Cohort) Study. The subjects for this analysis were 3,285 men and women, aged 35-69 years, selected from J-MICC Study participants; genotyping was conducted by multiplex polymerase chain reaction-based Invader assay. The prevalence of CKD was determined for CKD stages 3-5 (defined as eGFR < 60 ml/min/1.73 m2). Participants with CKD accounted for 17.3% of the study population. When those with PPARD T-842C T/T were defined as reference, those with PPARD T-842C T/C and C/C demonstrated the OR for CKD of 1.26 (95%CI 1.04-1.53) and 1.31 (95%CI 0.83-2.06), respectively. There were no significant associations between the polymorphisms in other PPAR genes and the risk of CKD. The present study found a significantly increased risk of CKD in those with the C allele of PPARD T-842C, which may suggest the possibility of personalized risk estimation of this life-limiting disease in the near future.
UR - http://www.scopus.com/inward/record.url?scp=84888874108&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84888874108&partnerID=8YFLogxK
U2 - 10.1155/2013/980471
DO - 10.1155/2013/980471
M3 - Article
AN - SCOPUS:84888874108
JO - PPAR Research
JF - PPAR Research
SN - 1687-4757
M1 - 980471
ER -