Polymorphisms of cytochrome P450 1A1, glutathione S-transferase class mu, and tumour protein p53 genes and the risk of developing gallbladder cancer in Japanese

Yasuo Tsuchiya, Chikako Kiyohara, Toyoji Sato, Kazutoshi Nakamura, Akira Kimura, Masaharu Yamamoto

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objectives: To examine the relationship between genetic polymorphisms of cytochrome P450 1A1 (CYP1A1), glutathione S-transferase class mu (GSTM1), and tumour protein p53 (TP53) genes, and gallbladder cancer (GBC) risk, a case-control study was conducted. Design and methods: Genotypes of CYP1A1 T3801C, CYP1A1 Ile462Val, GSTM1, and TP53 Arg72Pro were determined in 54 cases of GBC and 178 controls. Results: The age-adjusted odds ratios (ORs) for the Ile/Val genotype of CYP1A1 Ile462Val polymorphism in women and the Arg/Pro genotype of TP53 Arg72Pro polymorphism in men were observed to be 2.70 (95% CI: 1.14-6.40) and 4.32 (95% CI: 1.08-17.2), respectively. No significant differences in the genotypic frequencies of CYP1A1 T3801C and GSTM1 polymorphisms were observed between controls and cases in both men and women. Conclusion: These results suggest that the Val allele of CYP1A1 Ile462Val polymorphism and the Pro allele of TP53 Arg72Pro polymorphism contribute to an increased risk of GBC among Japanese women and men, respectively.

Original languageEnglish
Pages (from-to)881-886
Number of pages6
JournalClinical Biochemistry
Volume40
Issue number12
DOIs
Publication statusPublished - Aug 2007

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

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