Polymorphisms of cytochrome P450 1A1, glutathione S-transferase class mu, and tumour protein p53 genes and the risk of developing gallbladder cancer in Japanese

Yasuo Tsuchiya, Chikako Kiyohara, Toyoji Sato, Kazutoshi Nakamura, Akira Kimura, Masaharu Yamamoto

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objectives: To examine the relationship between genetic polymorphisms of cytochrome P450 1A1 (CYP1A1), glutathione S-transferase class mu (GSTM1), and tumour protein p53 (TP53) genes, and gallbladder cancer (GBC) risk, a case-control study was conducted. Design and methods: Genotypes of CYP1A1 T3801C, CYP1A1 Ile462Val, GSTM1, and TP53 Arg72Pro were determined in 54 cases of GBC and 178 controls. Results: The age-adjusted odds ratios (ORs) for the Ile/Val genotype of CYP1A1 Ile462Val polymorphism in women and the Arg/Pro genotype of TP53 Arg72Pro polymorphism in men were observed to be 2.70 (95% CI: 1.14-6.40) and 4.32 (95% CI: 1.08-17.2), respectively. No significant differences in the genotypic frequencies of CYP1A1 T3801C and GSTM1 polymorphisms were observed between controls and cases in both men and women. Conclusion: These results suggest that the Val allele of CYP1A1 Ile462Val polymorphism and the Pro allele of TP53 Arg72Pro polymorphism contribute to an increased risk of GBC among Japanese women and men, respectively.

Original languageEnglish
Pages (from-to)881-886
Number of pages6
JournalClinical Biochemistry
Volume40
Issue number12
DOIs
Publication statusPublished - Aug 1 2007

Fingerprint

Gallbladder Neoplasms
p53 Genes
Glutathione Transferase
Polymorphism
Cytochrome P-450 Enzyme System
Tumors
Genes
Neoplasms
Proteins
Genotype
Alleles
Genetic Polymorphisms
Case-Control Studies
Odds Ratio

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Polymorphisms of cytochrome P450 1A1, glutathione S-transferase class mu, and tumour protein p53 genes and the risk of developing gallbladder cancer in Japanese. / Tsuchiya, Yasuo; Kiyohara, Chikako; Sato, Toyoji; Nakamura, Kazutoshi; Kimura, Akira; Yamamoto, Masaharu.

In: Clinical Biochemistry, Vol. 40, No. 12, 01.08.2007, p. 881-886.

Research output: Contribution to journalArticle

Tsuchiya, Yasuo ; Kiyohara, Chikako ; Sato, Toyoji ; Nakamura, Kazutoshi ; Kimura, Akira ; Yamamoto, Masaharu. / Polymorphisms of cytochrome P450 1A1, glutathione S-transferase class mu, and tumour protein p53 genes and the risk of developing gallbladder cancer in Japanese. In: Clinical Biochemistry. 2007 ; Vol. 40, No. 12. pp. 881-886.
@article{75b8862bfc2f47e48f90a416fe3d34c1,
title = "Polymorphisms of cytochrome P450 1A1, glutathione S-transferase class mu, and tumour protein p53 genes and the risk of developing gallbladder cancer in Japanese",
abstract = "Objectives: To examine the relationship between genetic polymorphisms of cytochrome P450 1A1 (CYP1A1), glutathione S-transferase class mu (GSTM1), and tumour protein p53 (TP53) genes, and gallbladder cancer (GBC) risk, a case-control study was conducted. Design and methods: Genotypes of CYP1A1 T3801C, CYP1A1 Ile462Val, GSTM1, and TP53 Arg72Pro were determined in 54 cases of GBC and 178 controls. Results: The age-adjusted odds ratios (ORs) for the Ile/Val genotype of CYP1A1 Ile462Val polymorphism in women and the Arg/Pro genotype of TP53 Arg72Pro polymorphism in men were observed to be 2.70 (95{\%} CI: 1.14-6.40) and 4.32 (95{\%} CI: 1.08-17.2), respectively. No significant differences in the genotypic frequencies of CYP1A1 T3801C and GSTM1 polymorphisms were observed between controls and cases in both men and women. Conclusion: These results suggest that the Val allele of CYP1A1 Ile462Val polymorphism and the Pro allele of TP53 Arg72Pro polymorphism contribute to an increased risk of GBC among Japanese women and men, respectively.",
author = "Yasuo Tsuchiya and Chikako Kiyohara and Toyoji Sato and Kazutoshi Nakamura and Akira Kimura and Masaharu Yamamoto",
year = "2007",
month = "8",
day = "1",
doi = "10.1016/j.clinbiochem.2007.04.005",
language = "English",
volume = "40",
pages = "881--886",
journal = "Clinical Biochemistry",
issn = "0009-9120",
publisher = "Elsevier Inc.",
number = "12",

}

TY - JOUR

T1 - Polymorphisms of cytochrome P450 1A1, glutathione S-transferase class mu, and tumour protein p53 genes and the risk of developing gallbladder cancer in Japanese

AU - Tsuchiya, Yasuo

AU - Kiyohara, Chikako

AU - Sato, Toyoji

AU - Nakamura, Kazutoshi

AU - Kimura, Akira

AU - Yamamoto, Masaharu

PY - 2007/8/1

Y1 - 2007/8/1

N2 - Objectives: To examine the relationship between genetic polymorphisms of cytochrome P450 1A1 (CYP1A1), glutathione S-transferase class mu (GSTM1), and tumour protein p53 (TP53) genes, and gallbladder cancer (GBC) risk, a case-control study was conducted. Design and methods: Genotypes of CYP1A1 T3801C, CYP1A1 Ile462Val, GSTM1, and TP53 Arg72Pro were determined in 54 cases of GBC and 178 controls. Results: The age-adjusted odds ratios (ORs) for the Ile/Val genotype of CYP1A1 Ile462Val polymorphism in women and the Arg/Pro genotype of TP53 Arg72Pro polymorphism in men were observed to be 2.70 (95% CI: 1.14-6.40) and 4.32 (95% CI: 1.08-17.2), respectively. No significant differences in the genotypic frequencies of CYP1A1 T3801C and GSTM1 polymorphisms were observed between controls and cases in both men and women. Conclusion: These results suggest that the Val allele of CYP1A1 Ile462Val polymorphism and the Pro allele of TP53 Arg72Pro polymorphism contribute to an increased risk of GBC among Japanese women and men, respectively.

AB - Objectives: To examine the relationship between genetic polymorphisms of cytochrome P450 1A1 (CYP1A1), glutathione S-transferase class mu (GSTM1), and tumour protein p53 (TP53) genes, and gallbladder cancer (GBC) risk, a case-control study was conducted. Design and methods: Genotypes of CYP1A1 T3801C, CYP1A1 Ile462Val, GSTM1, and TP53 Arg72Pro were determined in 54 cases of GBC and 178 controls. Results: The age-adjusted odds ratios (ORs) for the Ile/Val genotype of CYP1A1 Ile462Val polymorphism in women and the Arg/Pro genotype of TP53 Arg72Pro polymorphism in men were observed to be 2.70 (95% CI: 1.14-6.40) and 4.32 (95% CI: 1.08-17.2), respectively. No significant differences in the genotypic frequencies of CYP1A1 T3801C and GSTM1 polymorphisms were observed between controls and cases in both men and women. Conclusion: These results suggest that the Val allele of CYP1A1 Ile462Val polymorphism and the Pro allele of TP53 Arg72Pro polymorphism contribute to an increased risk of GBC among Japanese women and men, respectively.

UR - http://www.scopus.com/inward/record.url?scp=34447550353&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34447550353&partnerID=8YFLogxK

U2 - 10.1016/j.clinbiochem.2007.04.005

DO - 10.1016/j.clinbiochem.2007.04.005

M3 - Article

C2 - 17531965

AN - SCOPUS:34447550353

VL - 40

SP - 881

EP - 886

JO - Clinical Biochemistry

JF - Clinical Biochemistry

SN - 0009-9120

IS - 12

ER -