Polymorphisms of IL-1β Gene in Japanese Patients with Sjögren's Syndrome and Systemic Lupus Erythematosus

Yoshifumi Muraki, Akito Tsutsumi, Reiko Takahashi, Eiji Suzuki, Taichi Hayashi, Yusuke Chino, Daisuke Goto, Isao Matsumoto, Hideyuki Murata, Emiko Noguchi, Takayuki Sumida

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Objective. Interleukin (IL)-1β is a proinflammatory cytokine involved in various immune responses. Five polymorphisms in the IL-1β gene have been described, and relationships between these polymorphisms and some autoimmune diseases have been reported. Evidence suggests that IL-1β may be involved in the destruction of salivary and lacrimal glands in Sjögren's syndrome (SS). We evaluated the significance of IL-1β gene polymorphisms in SS. Methods. Blood samples were taken from 101 patients with SS, 103 patients with systemic lupus erythematosus (SLE, excluding those with secondary SS), and 106 healthy volunteers. Each polymorphism of the IL-1β gene was analyzed by polymerase chain reaction (PCR) amplification of the polymorphic site, followed by site-specific restriction digestion. Genotype frequencies of each polymorphism in SS patients were compared with those of the controls and SLE patients, and differences between primary and secondary SS patients were also compared. Results. Genotypes CC, TT, and AA in positions -511, -31, and 3877, respectively, were significantly less frequent in SS patients than controls or patients with SLE. No significant differences were found in genotype frequencies of any of the polymorphisms between patients with primary SS and secondary SS. Conclusion. IL-1β gene polymorphisms may affect susceptibility to SS, but not SLE.

Original languageEnglish
Pages (from-to)720-725
Number of pages6
JournalJournal of Rheumatology
Volume31
Issue number4
Publication statusPublished - Apr 1 2004

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Interleukin-1
Systemic Lupus Erythematosus
Genes
Genotype
Lacrimal Apparatus
Salivary Glands
Autoimmune Diseases
Digestion
Healthy Volunteers
Cytokines
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

Muraki, Y., Tsutsumi, A., Takahashi, R., Suzuki, E., Hayashi, T., Chino, Y., ... Sumida, T. (2004). Polymorphisms of IL-1β Gene in Japanese Patients with Sjögren's Syndrome and Systemic Lupus Erythematosus. Journal of Rheumatology, 31(4), 720-725.

Polymorphisms of IL-1β Gene in Japanese Patients with Sjögren's Syndrome and Systemic Lupus Erythematosus. / Muraki, Yoshifumi; Tsutsumi, Akito; Takahashi, Reiko; Suzuki, Eiji; Hayashi, Taichi; Chino, Yusuke; Goto, Daisuke; Matsumoto, Isao; Murata, Hideyuki; Noguchi, Emiko; Sumida, Takayuki.

In: Journal of Rheumatology, Vol. 31, No. 4, 01.04.2004, p. 720-725.

Research output: Contribution to journalArticle

Muraki, Y, Tsutsumi, A, Takahashi, R, Suzuki, E, Hayashi, T, Chino, Y, Goto, D, Matsumoto, I, Murata, H, Noguchi, E & Sumida, T 2004, 'Polymorphisms of IL-1β Gene in Japanese Patients with Sjögren's Syndrome and Systemic Lupus Erythematosus', Journal of Rheumatology, vol. 31, no. 4, pp. 720-725.
Muraki Y, Tsutsumi A, Takahashi R, Suzuki E, Hayashi T, Chino Y et al. Polymorphisms of IL-1β Gene in Japanese Patients with Sjögren's Syndrome and Systemic Lupus Erythematosus. Journal of Rheumatology. 2004 Apr 1;31(4):720-725.
Muraki, Yoshifumi ; Tsutsumi, Akito ; Takahashi, Reiko ; Suzuki, Eiji ; Hayashi, Taichi ; Chino, Yusuke ; Goto, Daisuke ; Matsumoto, Isao ; Murata, Hideyuki ; Noguchi, Emiko ; Sumida, Takayuki. / Polymorphisms of IL-1β Gene in Japanese Patients with Sjögren's Syndrome and Systemic Lupus Erythematosus. In: Journal of Rheumatology. 2004 ; Vol. 31, No. 4. pp. 720-725.
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AU - Suzuki, Eiji

AU - Hayashi, Taichi

AU - Chino, Yusuke

AU - Goto, Daisuke

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