Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population

Emi Hamano; Minako Hijikata; Satoru Itoyama; Tran Quy; Nguyen Chi Phi; Hoang Thuy Long; Le Dang Ha; Vo Van Ban; Ikumi Matsushita; Hideki Yanai; Fumiko Kirikae; Teruo Kirikae; Tadatoshi Kuratsuji; Takehiko Sasazuki; Naoto Keicho

doi:10.1016/j.bbrc.2005.02.101

Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population

Emi Hamano, Minako Hijikata, Satoru Itoyama, Tran Quy, Nguyen Chi Phi, Hoang Thuy Long, Le Dang Ha, Vo Van Ban, Ikumi Matsushita, Hideki Yanai, Fumiko Kirikae, Teruo Kirikae, Tadatoshi Kuratsuji, Takehiko Sasazuki, Naoto Keicho

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Abstract

We hypothesized that host antiviral genes induced by type I interferons might affect the natural course of severe acute respiratory syndrome (SARS). We analyzed single nucleotide polymorphisms (SNPs) of 2′,5′- oligoadenylate synthetase 1 (OAS-1), myxovirus resistance-A (MxA), and double-stranded RNA-dependent protein kinase in 44 Vietnamese SARS patients with 103 controls. The G-allele of non-synonymous A/G SNP in exon 3 of OAS-1 gene showed association with SARS (p = 0.0090). The G-allele in exon 3 of OAS-1 and the one in exon 6 were in strong linkage disequilibrium and both of them were associated with SARS infection. The GG genotype and G-allele of G/T SNP at position -88 in the MxA gene promoter were found more frequently in hypoxemic group than in non-hypoxemic group of SARS (p = 0.0195). Our findings suggest that polymorphisms of two IFN-inducible genes OAS-1 and MxA might affect susceptibility to the disease and progression of SARS at each level.

Original language	English
Pages (from-to)	1234-1239
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	329
Issue number	4
DOIs	https://doi.org/10.1016/j.bbrc.2005.02.101
Publication status	Published - Apr 22 2005
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2005.02.101

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Hamano, E., Hijikata, M., Itoyama, S., Quy, T., Phi, N. C., Long, H. T., Ha, L. D., Ban, V. V., Matsushita, I., Yanai, H., Kirikae, F., Kirikae, T., Kuratsuji, T., Sasazuki, T., & Keicho, N. (2005). Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population. Biochemical and Biophysical Research Communications, 329(4), 1234-1239. https://doi.org/10.1016/j.bbrc.2005.02.101

Hamano, E, Hijikata, M, Itoyama, S, Quy, T, Phi, NC, Long, HT, Ha, LD, Ban, VV, Matsushita, I, Yanai, H, Kirikae, F, Kirikae, T, Kuratsuji, T, Sasazuki, T & Keicho, N 2005, 'Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population', Biochemical and Biophysical Research Communications, vol. 329, no. 4, pp. 1234-1239. https://doi.org/10.1016/j.bbrc.2005.02.101

@article{64c216c65dcc4d95ab2c3b559e7f196a,

title = "Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population",

abstract = "We hypothesized that host antiviral genes induced by type I interferons might affect the natural course of severe acute respiratory syndrome (SARS). We analyzed single nucleotide polymorphisms (SNPs) of 2′,5′- oligoadenylate synthetase 1 (OAS-1), myxovirus resistance-A (MxA), and double-stranded RNA-dependent protein kinase in 44 Vietnamese SARS patients with 103 controls. The G-allele of non-synonymous A/G SNP in exon 3 of OAS-1 gene showed association with SARS (p = 0.0090). The G-allele in exon 3 of OAS-1 and the one in exon 6 were in strong linkage disequilibrium and both of them were associated with SARS infection. The GG genotype and G-allele of G/T SNP at position -88 in the MxA gene promoter were found more frequently in hypoxemic group than in non-hypoxemic group of SARS (p = 0.0195). Our findings suggest that polymorphisms of two IFN-inducible genes OAS-1 and MxA might affect susceptibility to the disease and progression of SARS at each level.",

author = "Emi Hamano and Minako Hijikata and Satoru Itoyama and Tran Quy and Phi, {Nguyen Chi} and Long, {Hoang Thuy} and Ha, {Le Dang} and Ban, {Vo Van} and Ikumi Matsushita and Hideki Yanai and Fumiko Kirikae and Teruo Kirikae and Tadatoshi Kuratsuji and Takehiko Sasazuki and Naoto Keicho",

note = "Funding Information: The authors thank Dr. Nguyen Le Hang, Ms. Pham Thi Phuong Thuy, and Ms. Nguyen Thi Thu Ha for their help in the management and coordination of this study in Vietnam. The authors also thank Kazuko Tanabe D.V.M. and Mr. John Crosskey for their critical reading of the manuscript and Dr. Goh Tanaka for his help in statistical analysis. This work was supported by a grant for International Health Cooperation Research (14C-9) and for Research on Emerging and Re-emerging Infectious Diseases from the Ministry of Health, Labour and Welfare in 2004. ",

year = "2005",

month = apr,

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doi = "10.1016/j.bbrc.2005.02.101",

language = "English",

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T1 - Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population

AU - Hamano, Emi

AU - Hijikata, Minako

AU - Itoyama, Satoru

AU - Quy, Tran

AU - Phi, Nguyen Chi

AU - Long, Hoang Thuy

AU - Ha, Le Dang

AU - Ban, Vo Van

AU - Matsushita, Ikumi

AU - Yanai, Hideki

AU - Kirikae, Fumiko

AU - Kirikae, Teruo

AU - Kuratsuji, Tadatoshi

AU - Sasazuki, Takehiko

AU - Keicho, Naoto

N1 - Funding Information: The authors thank Dr. Nguyen Le Hang, Ms. Pham Thi Phuong Thuy, and Ms. Nguyen Thi Thu Ha for their help in the management and coordination of this study in Vietnam. The authors also thank Kazuko Tanabe D.V.M. and Mr. John Crosskey for their critical reading of the manuscript and Dr. Goh Tanaka for his help in statistical analysis. This work was supported by a grant for International Health Cooperation Research (14C-9) and for Research on Emerging and Re-emerging Infectious Diseases from the Ministry of Health, Labour and Welfare in 2004.

PY - 2005/4/22

Y1 - 2005/4/22

N2 - We hypothesized that host antiviral genes induced by type I interferons might affect the natural course of severe acute respiratory syndrome (SARS). We analyzed single nucleotide polymorphisms (SNPs) of 2′,5′- oligoadenylate synthetase 1 (OAS-1), myxovirus resistance-A (MxA), and double-stranded RNA-dependent protein kinase in 44 Vietnamese SARS patients with 103 controls. The G-allele of non-synonymous A/G SNP in exon 3 of OAS-1 gene showed association with SARS (p = 0.0090). The G-allele in exon 3 of OAS-1 and the one in exon 6 were in strong linkage disequilibrium and both of them were associated with SARS infection. The GG genotype and G-allele of G/T SNP at position -88 in the MxA gene promoter were found more frequently in hypoxemic group than in non-hypoxemic group of SARS (p = 0.0195). Our findings suggest that polymorphisms of two IFN-inducible genes OAS-1 and MxA might affect susceptibility to the disease and progression of SARS at each level.

AB - We hypothesized that host antiviral genes induced by type I interferons might affect the natural course of severe acute respiratory syndrome (SARS). We analyzed single nucleotide polymorphisms (SNPs) of 2′,5′- oligoadenylate synthetase 1 (OAS-1), myxovirus resistance-A (MxA), and double-stranded RNA-dependent protein kinase in 44 Vietnamese SARS patients with 103 controls. The G-allele of non-synonymous A/G SNP in exon 3 of OAS-1 gene showed association with SARS (p = 0.0090). The G-allele in exon 3 of OAS-1 and the one in exon 6 were in strong linkage disequilibrium and both of them were associated with SARS infection. The GG genotype and G-allele of G/T SNP at position -88 in the MxA gene promoter were found more frequently in hypoxemic group than in non-hypoxemic group of SARS (p = 0.0195). Our findings suggest that polymorphisms of two IFN-inducible genes OAS-1 and MxA might affect susceptibility to the disease and progression of SARS at each level.

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JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 4

ER -

Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population

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