Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population

Emi Hamano, Minako Hijikata, Satoru Itoyama, Tran Quy, Nguyen Chi Phi, Hoang Thuy Long, Le Dang Ha, Vo Van Ban, Ikumi Matsushita, Hideki Yanai, Fumiko Kirikae, Teruo Kirikae, Tadatoshi Kuratsuji, Takehiko Sasazuki, Naoto Keicho

Research output: Contribution to journalArticlepeer-review

68 Citations (Scopus)

Abstract

We hypothesized that host antiviral genes induced by type I interferons might affect the natural course of severe acute respiratory syndrome (SARS). We analyzed single nucleotide polymorphisms (SNPs) of 2′,5′- oligoadenylate synthetase 1 (OAS-1), myxovirus resistance-A (MxA), and double-stranded RNA-dependent protein kinase in 44 Vietnamese SARS patients with 103 controls. The G-allele of non-synonymous A/G SNP in exon 3 of OAS-1 gene showed association with SARS (p = 0.0090). The G-allele in exon 3 of OAS-1 and the one in exon 6 were in strong linkage disequilibrium and both of them were associated with SARS infection. The GG genotype and G-allele of G/T SNP at position -88 in the MxA gene promoter were found more frequently in hypoxemic group than in non-hypoxemic group of SARS (p = 0.0195). Our findings suggest that polymorphisms of two IFN-inducible genes OAS-1 and MxA might affect susceptibility to the disease and progression of SARS at each level.

Original languageEnglish
Pages (from-to)1234-1239
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume329
Issue number4
DOIs
Publication statusPublished - Apr 22 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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