Polymyxin-B immobilized column–direct hemoperfusion for adolescent toxic shock syndrome

Etsuro Nanishi, Yuichirou Hirata, Sooyoung Lee, Noriyuki Kaku, Kenta Momii, Kensuke Kubota, Hisanori Nishio, Yoshihiko Maehara, Toshiro Hara

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Toxic shock syndrome (TSS) is a critical illness associated with toxin from Staphylococcus aureus. Despite recent advances in critical care, mortality remains high and additional effective therapy is required. We report an adolescent case of TSS successfully treated with direct hemoperfusion using polymyxin-B immobilized fiber (PMX-DHP). The patient with spina bifida also had ischial pressure ulcer, and developed TSS associated with methicillin-resistant S. aureus. Despite conventional treatment, the patient developed refractory shock, which was immediately improved with PMX-DHP. PMX-DHP has been widely used for the treatment of sepsis to remove circulating endotoxins produced by Gram-negative bacteria, but beneficial effects have also been reported for Gram-positive bacterial infection. To our knowledge, this is the first report on PMX-DHP for TSS in an adolescent patient, and we propose that PMX-DHP could be a new treatment strategy for severe TSS in children as well.

Original languageEnglish
Pages (from-to)1051-1054
Number of pages4
JournalPediatrics International
Volume58
Issue number10
DOIs
Publication statusPublished - Oct 1 2016

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Hemoperfusion
Polymyxin B
Septic Shock
Gram-Positive Bacterial Infections
Methicillin Resistance
Spinal Dysraphism
Pressure Ulcer
Therapeutics
Critical Care
Gram-Negative Bacteria
Critical Illness
Endotoxins
Staphylococcus aureus
Shock
Sepsis
Mortality

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Polymyxin-B immobilized column–direct hemoperfusion for adolescent toxic shock syndrome. / Nanishi, Etsuro; Hirata, Yuichirou; Lee, Sooyoung; Kaku, Noriyuki; Momii, Kenta; Kubota, Kensuke; Nishio, Hisanori; Maehara, Yoshihiko; Hara, Toshiro.

In: Pediatrics International, Vol. 58, No. 10, 01.10.2016, p. 1051-1054.

Research output: Contribution to journalArticle

Nanishi, Etsuro ; Hirata, Yuichirou ; Lee, Sooyoung ; Kaku, Noriyuki ; Momii, Kenta ; Kubota, Kensuke ; Nishio, Hisanori ; Maehara, Yoshihiko ; Hara, Toshiro. / Polymyxin-B immobilized column–direct hemoperfusion for adolescent toxic shock syndrome. In: Pediatrics International. 2016 ; Vol. 58, No. 10. pp. 1051-1054.
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AU - Kubota, Kensuke

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