Polyps with Different Grades of Dysplasia and their Distribution in the Colorectum

Manabu Yamamoto, Hiroyuki Mine, Hiroki Kusumoto, Yoshihiko Maehara, Keizo Sugimachi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background/Aims: To determine the role of adenomatous polyps in the development of colorectal cancers, we examined the relationship between the distribution and polyps with different grades of dysplasia (low, high), or/and cancers in the colorectum. Methodology: The distribution of 527 polyps with low-grade dysplasia was compared with that of 121 polyps with high-grade dysplasia, and 10 colorectal cancer lesions with adenomatous polyps in 361 patients who underwent total colonoscopy. Results: The distribution rate of polyps at the distal colon and rectum into polyps with high-grade dysplasia significantly increased in comparison to that into polyps with low-grade dysplasia, respectively (p < 0.002). The percentage of polyps with high-grade dysplasia measuring > 1cm significantly increased in comparison to that with low-grade dysplasia measuring > 1cm (p < 0.00001). In patients with both adenomatous polyps and colorectal cancers, the polyps with high-grade dysplasia at the distal sites of cancerous lesions increased significantly more than at the proximal sites of cancerous lesions (p < 0.05). Polyps with high-grade dysplasia have malignant potentials to intermediate between polyps with low-grade dysplasia and colorectal cancers in our study. Conclusions: The different distributions of different grades thus suggested that polyps with different grades of dysplasia at various colorectal sites were found to have different malignant potentials for cancer development.

Original languageEnglish
Pages (from-to)121-123
Number of pages3
JournalHepato-gastroenterology
Volume51
Issue number55
Publication statusPublished - Jan 1 2004

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Polyps
Adenomatous Polyps
Colorectal Neoplasms
Colonoscopy
Rectum
Neoplasms
Colon

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Yamamoto, M., Mine, H., Kusumoto, H., Maehara, Y., & Sugimachi, K. (2004). Polyps with Different Grades of Dysplasia and their Distribution in the Colorectum. Hepato-gastroenterology, 51(55), 121-123.

Polyps with Different Grades of Dysplasia and their Distribution in the Colorectum. / Yamamoto, Manabu; Mine, Hiroyuki; Kusumoto, Hiroki; Maehara, Yoshihiko; Sugimachi, Keizo.

In: Hepato-gastroenterology, Vol. 51, No. 55, 01.01.2004, p. 121-123.

Research output: Contribution to journalArticle

Yamamoto, M, Mine, H, Kusumoto, H, Maehara, Y & Sugimachi, K 2004, 'Polyps with Different Grades of Dysplasia and their Distribution in the Colorectum', Hepato-gastroenterology, vol. 51, no. 55, pp. 121-123.
Yamamoto M, Mine H, Kusumoto H, Maehara Y, Sugimachi K. Polyps with Different Grades of Dysplasia and their Distribution in the Colorectum. Hepato-gastroenterology. 2004 Jan 1;51(55):121-123.
Yamamoto, Manabu ; Mine, Hiroyuki ; Kusumoto, Hiroki ; Maehara, Yoshihiko ; Sugimachi, Keizo. / Polyps with Different Grades of Dysplasia and their Distribution in the Colorectum. In: Hepato-gastroenterology. 2004 ; Vol. 51, No. 55. pp. 121-123.
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