Poly([R]-3-hydroxybutyrate-co-glycolate)

A novel PHB derivative chemically synthesized by copolymerization of a new cyclic diester monomer [R]-4-methyl-1,5-dioxepane-2,6-dione [1]

Shigehiro Hiki, Ikuo Taniguchi, Masatoshi Miyamoto, Yoshiharu Kimura

Research output: Contribution to journalLetter

7 Citations (Scopus)

Abstract

The synthesis of cyclic diester monomer consisting of [R]-3-hydroxybutyrate (3HB) and GA, [R]-4-methyl-1, 5-dioxepane-2, 6-dione([R]-MDP), and its copolymerization with [R]-β-butyrolactone ([R]-βBL) to prepare poly([R]-3-hydroxybutyrate-co-glycolate) (P(3HB-GA)) was discussed. The GA unit whose hydrolyzability was naturally induced in an aqueous environment, increased the nonenzymatic hydrolyzability of the (P(3HB-GA)). The analysis showed that this copolymerization using the monomer [R]-MDP afforded a synthetic route to (P(3HB-GA)) which was not possible to synthesized by bacterial fermentation.

Original languageEnglish
Pages (from-to)2423-2425
Number of pages3
JournalMacromolecules
Volume35
Issue number7
DOIs
Publication statusPublished - Mar 26 2002
Externally publishedYes

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glycolic acid
3-Hydroxybutyric Acid
Copolymerization
Monomers
Derivatives
Fermentation

All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

Cite this

Poly([R]-3-hydroxybutyrate-co-glycolate) : A novel PHB derivative chemically synthesized by copolymerization of a new cyclic diester monomer [R]-4-methyl-1,5-dioxepane-2,6-dione [1]. / Hiki, Shigehiro; Taniguchi, Ikuo; Miyamoto, Masatoshi; Kimura, Yoshiharu.

In: Macromolecules, Vol. 35, No. 7, 26.03.2002, p. 2423-2425.

Research output: Contribution to journalLetter

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title = "Poly([R]-3-hydroxybutyrate-co-glycolate): A novel PHB derivative chemically synthesized by copolymerization of a new cyclic diester monomer [R]-4-methyl-1,5-dioxepane-2,6-dione [1]",
abstract = "The synthesis of cyclic diester monomer consisting of [R]-3-hydroxybutyrate (3HB) and GA, [R]-4-methyl-1, 5-dioxepane-2, 6-dione([R]-MDP), and its copolymerization with [R]-β-butyrolactone ([R]-βBL) to prepare poly([R]-3-hydroxybutyrate-co-glycolate) (P(3HB-GA)) was discussed. The GA unit whose hydrolyzability was naturally induced in an aqueous environment, increased the nonenzymatic hydrolyzability of the (P(3HB-GA)). The analysis showed that this copolymerization using the monomer [R]-MDP afforded a synthetic route to (P(3HB-GA)) which was not possible to synthesized by bacterial fermentation.",
author = "Shigehiro Hiki and Ikuo Taniguchi and Masatoshi Miyamoto and Yoshiharu Kimura",
year = "2002",
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T1 - Poly([R]-3-hydroxybutyrate-co-glycolate)

T2 - A novel PHB derivative chemically synthesized by copolymerization of a new cyclic diester monomer [R]-4-methyl-1,5-dioxepane-2,6-dione [1]

AU - Hiki, Shigehiro

AU - Taniguchi, Ikuo

AU - Miyamoto, Masatoshi

AU - Kimura, Yoshiharu

PY - 2002/3/26

Y1 - 2002/3/26

N2 - The synthesis of cyclic diester monomer consisting of [R]-3-hydroxybutyrate (3HB) and GA, [R]-4-methyl-1, 5-dioxepane-2, 6-dione([R]-MDP), and its copolymerization with [R]-β-butyrolactone ([R]-βBL) to prepare poly([R]-3-hydroxybutyrate-co-glycolate) (P(3HB-GA)) was discussed. The GA unit whose hydrolyzability was naturally induced in an aqueous environment, increased the nonenzymatic hydrolyzability of the (P(3HB-GA)). The analysis showed that this copolymerization using the monomer [R]-MDP afforded a synthetic route to (P(3HB-GA)) which was not possible to synthesized by bacterial fermentation.

AB - The synthesis of cyclic diester monomer consisting of [R]-3-hydroxybutyrate (3HB) and GA, [R]-4-methyl-1, 5-dioxepane-2, 6-dione([R]-MDP), and its copolymerization with [R]-β-butyrolactone ([R]-βBL) to prepare poly([R]-3-hydroxybutyrate-co-glycolate) (P(3HB-GA)) was discussed. The GA unit whose hydrolyzability was naturally induced in an aqueous environment, increased the nonenzymatic hydrolyzability of the (P(3HB-GA)). The analysis showed that this copolymerization using the monomer [R]-MDP afforded a synthetic route to (P(3HB-GA)) which was not possible to synthesized by bacterial fermentation.

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U2 - 10.1021/ma011637l

DO - 10.1021/ma011637l

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