Polysaccharide conjugates as bionanomaterials

Shinichi Mochizuki, Arihiro Kano, Toshihiro Akaike, Atsushi Maruyama

Research output: Contribution to journalArticle

Abstract

Carbohydrates have several unique biofunctions that are useful for drug delivery systems. If one plans to utilize these functions, glyco-conjugate design and chemistry are important. Glyco-conjugate materials consisting of polymeric materials and polysaccharide for DDS were described. Liver sinusoidal endothelial cells (LSECs) possess unique receptors that recognize and internalize hyaluronan (HA). We used this characteristic of HA and the unique assembling properties of comb-type polycations with DNA to develop a system for targeting foreign DNAs for LSECs. New comb-type copolymers composed of HA and PLL (PLL-g-HA) formed complexes with DNA, permitting specific targeting of DNAs to the LSECs. The PLL-g-HA gene carrier system may open a new and more effective strategy to treat intractable liver diseases through manipulation of LSECs functions by gene engineering.

Original languageEnglish
Pages (from-to)601-605
Number of pages5
JournalKOBUNSHI RONBUNSHU
Volume61
Issue number12
DOIs
Publication statusPublished - Jan 1 2004
Externally publishedYes

Fingerprint

Hyaluronic Acid
Polysaccharides
polysaccharide
Liver
Endothelial cells
DNA
Phase locked loops
targeting
Genes
gene
Open systems
carbohydrate
Carbohydrates
drug
engineering
Copolymers
Polymers
material

All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Materials Science (miscellaneous)
  • Environmental Science(all)
  • Polymers and Plastics

Cite this

Polysaccharide conjugates as bionanomaterials. / Mochizuki, Shinichi; Kano, Arihiro; Akaike, Toshihiro; Maruyama, Atsushi.

In: KOBUNSHI RONBUNSHU, Vol. 61, No. 12, 01.01.2004, p. 601-605.

Research output: Contribution to journalArticle

Mochizuki, S, Kano, A, Akaike, T & Maruyama, A 2004, 'Polysaccharide conjugates as bionanomaterials', KOBUNSHI RONBUNSHU, vol. 61, no. 12, pp. 601-605. https://doi.org/10.1295/koron.61.601
Mochizuki, Shinichi ; Kano, Arihiro ; Akaike, Toshihiro ; Maruyama, Atsushi. / Polysaccharide conjugates as bionanomaterials. In: KOBUNSHI RONBUNSHU. 2004 ; Vol. 61, No. 12. pp. 601-605.
@article{239ea27de08844abb2d9865306200b4d,
title = "Polysaccharide conjugates as bionanomaterials",
abstract = "Carbohydrates have several unique biofunctions that are useful for drug delivery systems. If one plans to utilize these functions, glyco-conjugate design and chemistry are important. Glyco-conjugate materials consisting of polymeric materials and polysaccharide for DDS were described. Liver sinusoidal endothelial cells (LSECs) possess unique receptors that recognize and internalize hyaluronan (HA). We used this characteristic of HA and the unique assembling properties of comb-type polycations with DNA to develop a system for targeting foreign DNAs for LSECs. New comb-type copolymers composed of HA and PLL (PLL-g-HA) formed complexes with DNA, permitting specific targeting of DNAs to the LSECs. The PLL-g-HA gene carrier system may open a new and more effective strategy to treat intractable liver diseases through manipulation of LSECs functions by gene engineering.",
author = "Shinichi Mochizuki and Arihiro Kano and Toshihiro Akaike and Atsushi Maruyama",
year = "2004",
month = "1",
day = "1",
doi = "10.1295/koron.61.601",
language = "English",
volume = "61",
pages = "601--605",
journal = "Kobunshi Ronbunshu",
issn = "0386-2186",
publisher = "The Society of Polymer Science, Japan",
number = "12",

}

TY - JOUR

T1 - Polysaccharide conjugates as bionanomaterials

AU - Mochizuki, Shinichi

AU - Kano, Arihiro

AU - Akaike, Toshihiro

AU - Maruyama, Atsushi

PY - 2004/1/1

Y1 - 2004/1/1

N2 - Carbohydrates have several unique biofunctions that are useful for drug delivery systems. If one plans to utilize these functions, glyco-conjugate design and chemistry are important. Glyco-conjugate materials consisting of polymeric materials and polysaccharide for DDS were described. Liver sinusoidal endothelial cells (LSECs) possess unique receptors that recognize and internalize hyaluronan (HA). We used this characteristic of HA and the unique assembling properties of comb-type polycations with DNA to develop a system for targeting foreign DNAs for LSECs. New comb-type copolymers composed of HA and PLL (PLL-g-HA) formed complexes with DNA, permitting specific targeting of DNAs to the LSECs. The PLL-g-HA gene carrier system may open a new and more effective strategy to treat intractable liver diseases through manipulation of LSECs functions by gene engineering.

AB - Carbohydrates have several unique biofunctions that are useful for drug delivery systems. If one plans to utilize these functions, glyco-conjugate design and chemistry are important. Glyco-conjugate materials consisting of polymeric materials and polysaccharide for DDS were described. Liver sinusoidal endothelial cells (LSECs) possess unique receptors that recognize and internalize hyaluronan (HA). We used this characteristic of HA and the unique assembling properties of comb-type polycations with DNA to develop a system for targeting foreign DNAs for LSECs. New comb-type copolymers composed of HA and PLL (PLL-g-HA) formed complexes with DNA, permitting specific targeting of DNAs to the LSECs. The PLL-g-HA gene carrier system may open a new and more effective strategy to treat intractable liver diseases through manipulation of LSECs functions by gene engineering.

UR - http://www.scopus.com/inward/record.url?scp=14044259239&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=14044259239&partnerID=8YFLogxK

U2 - 10.1295/koron.61.601

DO - 10.1295/koron.61.601

M3 - Article

AN - SCOPUS:14044259239

VL - 61

SP - 601

EP - 605

JO - Kobunshi Ronbunshu

JF - Kobunshi Ronbunshu

SN - 0386-2186

IS - 12

ER -