Abstract
Carbohydrates have several unique biofunctions that are useful for drug delivery systems. If one plans to utilize these functions, glyco-conjugate design and chemistry are important. Glyco-conjugate materials consisting of polymeric materials and polysaccharide for DDS were described. Liver sinusoidal endothelial cells (LSECs) possess unique receptors that recognize and internalize hyaluronan (HA). We used this characteristic of HA and the unique assembling properties of comb-type polycations with DNA to develop a system for targeting foreign DNAs for LSECs. New comb-type copolymers composed of HA and PLL (PLL-g-HA) formed complexes with DNA, permitting specific targeting of DNAs to the LSECs. The PLL-g-HA gene carrier system may open a new and more effective strategy to treat intractable liver diseases through manipulation of LSECs functions by gene engineering.
| Original language | English |
|---|---|
| Pages (from-to) | 601-605 |
| Number of pages | 5 |
| Journal | KOBUNSHI RONBUNSHU |
| Volume | 61 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Jan 1 2004 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Chemical Engineering (miscellaneous)
- Materials Science (miscellaneous)
- Environmental Science(all)
- Polymers and Plastics
Cite this
Polysaccharide conjugates as bionanomaterials. / Mochizuki, Shinichi; Kano, Arihiro; Akaike, Toshihiro; Maruyama, Atsushi.
In: KOBUNSHI RONBUNSHU, Vol. 61, No. 12, 01.01.2004, p. 601-605.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Polysaccharide conjugates as bionanomaterials
AU - Mochizuki, Shinichi
AU - Kano, Arihiro
AU - Akaike, Toshihiro
AU - Maruyama, Atsushi
PY - 2004/1/1
Y1 - 2004/1/1
N2 - Carbohydrates have several unique biofunctions that are useful for drug delivery systems. If one plans to utilize these functions, glyco-conjugate design and chemistry are important. Glyco-conjugate materials consisting of polymeric materials and polysaccharide for DDS were described. Liver sinusoidal endothelial cells (LSECs) possess unique receptors that recognize and internalize hyaluronan (HA). We used this characteristic of HA and the unique assembling properties of comb-type polycations with DNA to develop a system for targeting foreign DNAs for LSECs. New comb-type copolymers composed of HA and PLL (PLL-g-HA) formed complexes with DNA, permitting specific targeting of DNAs to the LSECs. The PLL-g-HA gene carrier system may open a new and more effective strategy to treat intractable liver diseases through manipulation of LSECs functions by gene engineering.
AB - Carbohydrates have several unique biofunctions that are useful for drug delivery systems. If one plans to utilize these functions, glyco-conjugate design and chemistry are important. Glyco-conjugate materials consisting of polymeric materials and polysaccharide for DDS were described. Liver sinusoidal endothelial cells (LSECs) possess unique receptors that recognize and internalize hyaluronan (HA). We used this characteristic of HA and the unique assembling properties of comb-type polycations with DNA to develop a system for targeting foreign DNAs for LSECs. New comb-type copolymers composed of HA and PLL (PLL-g-HA) formed complexes with DNA, permitting specific targeting of DNAs to the LSECs. The PLL-g-HA gene carrier system may open a new and more effective strategy to treat intractable liver diseases through manipulation of LSECs functions by gene engineering.
UR - http://www.scopus.com/inward/record.url?scp=14044259239&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=14044259239&partnerID=8YFLogxK
U2 - 10.1295/koron.61.601
DO - 10.1295/koron.61.601
M3 - Article
AN - SCOPUS:14044259239
VL - 61
SP - 601
EP - 605
JO - Kobunshi Ronbunshu
JF - Kobunshi Ronbunshu
SN - 0386-2186
IS - 12
ER -