Polysaccharide conjugates as bionanomaterials

Shinichi Mochizuki; Arihiro Kano; Toshihiro Akaike; Atsushi Maruyama

doi:10.1295/koron.61.601

Polysaccharide conjugates as bionanomaterials

Shinichi Mochizuki, Arihiro Kano, Toshihiro Akaike, Atsushi Maruyama

Research output: Contribution to journal › Article › peer-review

Abstract

Carbohydrates have several unique biofunctions that are useful for drug delivery systems. If one plans to utilize these functions, glyco-conjugate design and chemistry are important. Glyco-conjugate materials consisting of polymeric materials and polysaccharide for DDS were described. Liver sinusoidal endothelial cells (LSECs) possess unique receptors that recognize and internalize hyaluronan (HA). We used this characteristic of HA and the unique assembling properties of comb-type polycations with DNA to develop a system for targeting foreign DNAs for LSECs. New comb-type copolymers composed of HA and PLL (PLL-g-HA) formed complexes with DNA, permitting specific targeting of DNAs to the LSECs. The PLL-g-HA gene carrier system may open a new and more effective strategy to treat intractable liver diseases through manipulation of LSECs functions by gene engineering.

Original language	English
Pages (from-to)	601-605
Number of pages	5
Journal	KOBUNSHI RONBUNSHU
Volume	61
Issue number	12
DOIs	https://doi.org/10.1295/koron.61.601
Publication status	Published - Jan 1 2004
Externally published	Yes

All Science Journal Classification (ASJC) codes

Chemical Engineering (miscellaneous)
Materials Science (miscellaneous)
Environmental Science(all)
Polymers and Plastics

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10.1295/koron.61.601

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abstract = "Carbohydrates have several unique biofunctions that are useful for drug delivery systems. If one plans to utilize these functions, glyco-conjugate design and chemistry are important. Glyco-conjugate materials consisting of polymeric materials and polysaccharide for DDS were described. Liver sinusoidal endothelial cells (LSECs) possess unique receptors that recognize and internalize hyaluronan (HA). We used this characteristic of HA and the unique assembling properties of comb-type polycations with DNA to develop a system for targeting foreign DNAs for LSECs. New comb-type copolymers composed of HA and PLL (PLL-g-HA) formed complexes with DNA, permitting specific targeting of DNAs to the LSECs. The PLL-g-HA gene carrier system may open a new and more effective strategy to treat intractable liver diseases through manipulation of LSECs functions by gene engineering.",

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AU - Mochizuki, Shinichi

AU - Kano, Arihiro

AU - Akaike, Toshihiro

AU - Maruyama, Atsushi

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