Polysaccharide-polynucleotide complexes (IV): Antihydrolysis effect of the schizophyllan/poly(C) complex and the complex dissociation induced by amines

Kazuya Koumoto, Taro Kimura, Kazuo Sakurai, Seiji Shinkai

Research output: Contribution to journalEditorial

10 Citations (Scopus)

Abstract

Polymer complexes formed by schizophyllan and poly(C) showed a unique antihydrolysis effect when poly(C) was subjected to hydrolysis under basic conditions. The complexation reduced the hydrolysis rate to 80% of the control (i.e., poly(C) itself). However, when we added oligoamines with the intention of catalyzing the hydrolysis, the oligoamines induced dissociation of the complex instead of acceleration of the hydrolysis.

Original languageEnglish
Pages (from-to)178-185
Number of pages8
JournalBioorganic Chemistry
Volume29
Issue number3
DOIs
Publication statusPublished - Jan 1 2001
Externally publishedYes

Fingerprint

Sizofiran
Poly C
Polynucleotides
Amines
Polysaccharides
Hydrolysis
Complexation
Polymers

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Drug Discovery
  • Organic Chemistry

Cite this

Polysaccharide-polynucleotide complexes (IV) : Antihydrolysis effect of the schizophyllan/poly(C) complex and the complex dissociation induced by amines. / Koumoto, Kazuya; Kimura, Taro; Sakurai, Kazuo; Shinkai, Seiji.

In: Bioorganic Chemistry, Vol. 29, No. 3, 01.01.2001, p. 178-185.

Research output: Contribution to journalEditorial

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