Porphyromonas gingivalis infection is associated with carotid atherosclerosis in non-obese Japanese type 2 diabetic patients

Ataru Taniguchi, Fusanori Nishimura, Yoji Murayama, Shoichiro Nagasaka, Mitsuo Fukushima, Masahiko Sakai, Satoru Yoshii, Akira Kuroe, Haruhiko Suzuki, Yoshihiro Iwamoto, Yoshihiko Soga, Takahide Okumura, Masahito Ogura, Yuichiro Yamada, Yutaka Seino, Yoshikatsu Nakai

Research output: Contribution to journalArticle

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Abstract

The aim of the present study was to investigate whether non-obese Japanese type 2 diabetic patients with porphyromonas gingivalis infection have atherosclerotic vascular diseases. A total of 134 non-obese Japanese type 2 diabetic patients (96 men and 38 women, aged 36 to 84 years, body mass index [BMI] 20.1 to 26.9 kg/m2) were studied. In conjunction with BMI, glycosylated hemoglobin (HbA1c), fasting glucose, and serum lipids (triglycerides, total cholesterol, high-density lipoprotein [HDL] cholesterol, low-density lipoprotein [LDL] cholesterol) were measured. LDL cholesterol was calculated using the Friedewald formula. Using high-resolution B-mode ultrasound scan, we measured intimal medial thickness (IMT) in plaque-free segments of bilateral common carotid arteries, and the mean of IMT in 2 vessels was used for the analysis. Furthermore, we calculated the degree of stenosis in plaque segments of bilateral common carotid arteries. The degree of carotid atherosclerosis was expressed as a percentage ratio between the area of plaque and that of the lumen using the formula (Lumen Area Residual - Lumen Area)/Lumem Area x 100. Both the areas were automatically measured by the system on a frozen transverse scanning plane at the site of maximal narrowing. When 2 or more plaques were present in the vessel, only that causing the greatest degree of stenosis was considered for analysis. Values represent mean±SEM unless otherwise stated. Immunoglobulin G (IgG) titer against porphyromonas gingivalis was 245 ± 65 (mean ± 2 SD) in nondiabetic healthy subjects. In contrast, there was a wide variation in IgG titer against porphyromonas gingivalis in type 2 diabetic patients studied (range, 16 to 26,800). Thus, we classified our type 2 diabetic patients into 2 subpopulations according to the value of mean ± 2 SD (= 310) of nondiabetic healthy subjects: one with high IgG titer against porphyromonas gingivalis (>310) (1,422 ± 408) and the other with normal IgG titer against porphyromonas gingivalis (<310) (152 ± 10, P = .002). The populations did not differ with respect to age, sex, BMI, fasting glucose, HbA1c, serum triglycerides, total, HDL, and LDL cholesterol levels. Although the mean IMT in plaque-free segments was not different between the 2 groups (0.73 ± 0.03 v 0.68 ± 0.02 mm, P = .098), the degree of stenosis in plaque segments was significantly higher in the high IgG titer group (12.0% ± 2.2%) than in normal one (5.5% ± 1.4%, P = .009). From these results, it can be concluded that porphyromonas gingivalis infection, although still a subclinical infection, is associated with atherosclerotic vascular disease in non-obese Japanese type 2 diabetic patients.

Original languageEnglish
Pages (from-to)142-145
Number of pages4
JournalMetabolism: Clinical and Experimental
Volume52
Issue number2
DOIs
Publication statusPublished - Feb 1 2003

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Porphyromonas gingivalis
Carotid Artery Diseases
Tunica Intima
Immunoglobulin G
Infection
LDL Cholesterol
Pathologic Constriction
Body Mass Index
Common Carotid Artery
Vascular Diseases
Fasting
Healthy Volunteers
Triglycerides
Glucose
Asymptomatic Infections
Glycosylated Hemoglobin A
HDL Lipoproteins
Serum
HDL Cholesterol
Cholesterol

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Porphyromonas gingivalis infection is associated with carotid atherosclerosis in non-obese Japanese type 2 diabetic patients. / Taniguchi, Ataru; Nishimura, Fusanori; Murayama, Yoji; Nagasaka, Shoichiro; Fukushima, Mitsuo; Sakai, Masahiko; Yoshii, Satoru; Kuroe, Akira; Suzuki, Haruhiko; Iwamoto, Yoshihiro; Soga, Yoshihiko; Okumura, Takahide; Ogura, Masahito; Yamada, Yuichiro; Seino, Yutaka; Nakai, Yoshikatsu.

In: Metabolism: Clinical and Experimental, Vol. 52, No. 2, 01.02.2003, p. 142-145.

Research output: Contribution to journalArticle

Taniguchi, A, Nishimura, F, Murayama, Y, Nagasaka, S, Fukushima, M, Sakai, M, Yoshii, S, Kuroe, A, Suzuki, H, Iwamoto, Y, Soga, Y, Okumura, T, Ogura, M, Yamada, Y, Seino, Y & Nakai, Y 2003, 'Porphyromonas gingivalis infection is associated with carotid atherosclerosis in non-obese Japanese type 2 diabetic patients', Metabolism: Clinical and Experimental, vol. 52, no. 2, pp. 142-145. https://doi.org/10.1053/meta.2003.50001
Taniguchi, Ataru ; Nishimura, Fusanori ; Murayama, Yoji ; Nagasaka, Shoichiro ; Fukushima, Mitsuo ; Sakai, Masahiko ; Yoshii, Satoru ; Kuroe, Akira ; Suzuki, Haruhiko ; Iwamoto, Yoshihiro ; Soga, Yoshihiko ; Okumura, Takahide ; Ogura, Masahito ; Yamada, Yuichiro ; Seino, Yutaka ; Nakai, Yoshikatsu. / Porphyromonas gingivalis infection is associated with carotid atherosclerosis in non-obese Japanese type 2 diabetic patients. In: Metabolism: Clinical and Experimental. 2003 ; Vol. 52, No. 2. pp. 142-145.
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abstract = "The aim of the present study was to investigate whether non-obese Japanese type 2 diabetic patients with porphyromonas gingivalis infection have atherosclerotic vascular diseases. A total of 134 non-obese Japanese type 2 diabetic patients (96 men and 38 women, aged 36 to 84 years, body mass index [BMI] 20.1 to 26.9 kg/m2) were studied. In conjunction with BMI, glycosylated hemoglobin (HbA1c), fasting glucose, and serum lipids (triglycerides, total cholesterol, high-density lipoprotein [HDL] cholesterol, low-density lipoprotein [LDL] cholesterol) were measured. LDL cholesterol was calculated using the Friedewald formula. Using high-resolution B-mode ultrasound scan, we measured intimal medial thickness (IMT) in plaque-free segments of bilateral common carotid arteries, and the mean of IMT in 2 vessels was used for the analysis. Furthermore, we calculated the degree of stenosis in plaque segments of bilateral common carotid arteries. The degree of carotid atherosclerosis was expressed as a percentage ratio between the area of plaque and that of the lumen using the formula (Lumen Area Residual - Lumen Area)/Lumem Area x 100. Both the areas were automatically measured by the system on a frozen transverse scanning plane at the site of maximal narrowing. When 2 or more plaques were present in the vessel, only that causing the greatest degree of stenosis was considered for analysis. Values represent mean±SEM unless otherwise stated. Immunoglobulin G (IgG) titer against porphyromonas gingivalis was 245 ± 65 (mean ± 2 SD) in nondiabetic healthy subjects. In contrast, there was a wide variation in IgG titer against porphyromonas gingivalis in type 2 diabetic patients studied (range, 16 to 26,800). Thus, we classified our type 2 diabetic patients into 2 subpopulations according to the value of mean ± 2 SD (= 310) of nondiabetic healthy subjects: one with high IgG titer against porphyromonas gingivalis (>310) (1,422 ± 408) and the other with normal IgG titer against porphyromonas gingivalis (<310) (152 ± 10, P = .002). The populations did not differ with respect to age, sex, BMI, fasting glucose, HbA1c, serum triglycerides, total, HDL, and LDL cholesterol levels. Although the mean IMT in plaque-free segments was not different between the 2 groups (0.73 ± 0.03 v 0.68 ± 0.02 mm, P = .098), the degree of stenosis in plaque segments was significantly higher in the high IgG titer group (12.0{\%} ± 2.2{\%}) than in normal one (5.5{\%} ± 1.4{\%}, P = .009). From these results, it can be concluded that porphyromonas gingivalis infection, although still a subclinical infection, is associated with atherosclerotic vascular disease in non-obese Japanese type 2 diabetic patients.",
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T1 - Porphyromonas gingivalis infection is associated with carotid atherosclerosis in non-obese Japanese type 2 diabetic patients

AU - Taniguchi, Ataru

AU - Nishimura, Fusanori

AU - Murayama, Yoji

AU - Nagasaka, Shoichiro

AU - Fukushima, Mitsuo

AU - Sakai, Masahiko

AU - Yoshii, Satoru

AU - Kuroe, Akira

AU - Suzuki, Haruhiko

AU - Iwamoto, Yoshihiro

AU - Soga, Yoshihiko

AU - Okumura, Takahide

AU - Ogura, Masahito

AU - Yamada, Yuichiro

AU - Seino, Yutaka

AU - Nakai, Yoshikatsu

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N2 - The aim of the present study was to investigate whether non-obese Japanese type 2 diabetic patients with porphyromonas gingivalis infection have atherosclerotic vascular diseases. A total of 134 non-obese Japanese type 2 diabetic patients (96 men and 38 women, aged 36 to 84 years, body mass index [BMI] 20.1 to 26.9 kg/m2) were studied. In conjunction with BMI, glycosylated hemoglobin (HbA1c), fasting glucose, and serum lipids (triglycerides, total cholesterol, high-density lipoprotein [HDL] cholesterol, low-density lipoprotein [LDL] cholesterol) were measured. LDL cholesterol was calculated using the Friedewald formula. Using high-resolution B-mode ultrasound scan, we measured intimal medial thickness (IMT) in plaque-free segments of bilateral common carotid arteries, and the mean of IMT in 2 vessels was used for the analysis. Furthermore, we calculated the degree of stenosis in plaque segments of bilateral common carotid arteries. The degree of carotid atherosclerosis was expressed as a percentage ratio between the area of plaque and that of the lumen using the formula (Lumen Area Residual - Lumen Area)/Lumem Area x 100. Both the areas were automatically measured by the system on a frozen transverse scanning plane at the site of maximal narrowing. When 2 or more plaques were present in the vessel, only that causing the greatest degree of stenosis was considered for analysis. Values represent mean±SEM unless otherwise stated. Immunoglobulin G (IgG) titer against porphyromonas gingivalis was 245 ± 65 (mean ± 2 SD) in nondiabetic healthy subjects. In contrast, there was a wide variation in IgG titer against porphyromonas gingivalis in type 2 diabetic patients studied (range, 16 to 26,800). Thus, we classified our type 2 diabetic patients into 2 subpopulations according to the value of mean ± 2 SD (= 310) of nondiabetic healthy subjects: one with high IgG titer against porphyromonas gingivalis (>310) (1,422 ± 408) and the other with normal IgG titer against porphyromonas gingivalis (<310) (152 ± 10, P = .002). The populations did not differ with respect to age, sex, BMI, fasting glucose, HbA1c, serum triglycerides, total, HDL, and LDL cholesterol levels. Although the mean IMT in plaque-free segments was not different between the 2 groups (0.73 ± 0.03 v 0.68 ± 0.02 mm, P = .098), the degree of stenosis in plaque segments was significantly higher in the high IgG titer group (12.0% ± 2.2%) than in normal one (5.5% ± 1.4%, P = .009). From these results, it can be concluded that porphyromonas gingivalis infection, although still a subclinical infection, is associated with atherosclerotic vascular disease in non-obese Japanese type 2 diabetic patients.

AB - The aim of the present study was to investigate whether non-obese Japanese type 2 diabetic patients with porphyromonas gingivalis infection have atherosclerotic vascular diseases. A total of 134 non-obese Japanese type 2 diabetic patients (96 men and 38 women, aged 36 to 84 years, body mass index [BMI] 20.1 to 26.9 kg/m2) were studied. In conjunction with BMI, glycosylated hemoglobin (HbA1c), fasting glucose, and serum lipids (triglycerides, total cholesterol, high-density lipoprotein [HDL] cholesterol, low-density lipoprotein [LDL] cholesterol) were measured. LDL cholesterol was calculated using the Friedewald formula. Using high-resolution B-mode ultrasound scan, we measured intimal medial thickness (IMT) in plaque-free segments of bilateral common carotid arteries, and the mean of IMT in 2 vessels was used for the analysis. Furthermore, we calculated the degree of stenosis in plaque segments of bilateral common carotid arteries. The degree of carotid atherosclerosis was expressed as a percentage ratio between the area of plaque and that of the lumen using the formula (Lumen Area Residual - Lumen Area)/Lumem Area x 100. Both the areas were automatically measured by the system on a frozen transverse scanning plane at the site of maximal narrowing. When 2 or more plaques were present in the vessel, only that causing the greatest degree of stenosis was considered for analysis. Values represent mean±SEM unless otherwise stated. Immunoglobulin G (IgG) titer against porphyromonas gingivalis was 245 ± 65 (mean ± 2 SD) in nondiabetic healthy subjects. In contrast, there was a wide variation in IgG titer against porphyromonas gingivalis in type 2 diabetic patients studied (range, 16 to 26,800). Thus, we classified our type 2 diabetic patients into 2 subpopulations according to the value of mean ± 2 SD (= 310) of nondiabetic healthy subjects: one with high IgG titer against porphyromonas gingivalis (>310) (1,422 ± 408) and the other with normal IgG titer against porphyromonas gingivalis (<310) (152 ± 10, P = .002). The populations did not differ with respect to age, sex, BMI, fasting glucose, HbA1c, serum triglycerides, total, HDL, and LDL cholesterol levels. Although the mean IMT in plaque-free segments was not different between the 2 groups (0.73 ± 0.03 v 0.68 ± 0.02 mm, P = .098), the degree of stenosis in plaque segments was significantly higher in the high IgG titer group (12.0% ± 2.2%) than in normal one (5.5% ± 1.4%, P = .009). From these results, it can be concluded that porphyromonas gingivalis infection, although still a subclinical infection, is associated with atherosclerotic vascular disease in non-obese Japanese type 2 diabetic patients.

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