Portal vein thrombosis after hepatectomy

Shohei Yoshiya, Ken Shirabe, Hidekazu Nakagawara, Yuji Soejima, Tomoharu Yoshizumi, Toru Ikegami, Yo Ichi Yamashita, Norifumi Harimoto, Akihiro Nishie, Takeharu Yamanaka, Yoshihiko Maehara

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22 Citations (Scopus)

Abstract

Background: Although various complications after hepatectomy have been reported, there have been no large studies on postoperative portal vein thrombosis (PVT) as a complication. This study evaluated the incidence, risk factors, and clinical outcomes of PVT after hepatectomy. Methods: The preoperative and postoperative clinical characteristics of patients who underwent hepatectomy were retrospectively analyzed. Results: A total of 208 patients were reviewed. The incidence of PVT after hepatectomy was 9.1 % (n = 19), including main portal vein (MPV) thrombosis (n = 7) and peripheral portal vein (PPV) thrombosis (n = 12). Patients with MPV thrombosis had a significantly higher incidence of right hepatectomy (p < 0.001), larger resection volume (p = 0.003), and longer operation time (p = 0.021) than patients without PVT (n = 189). Multivariate analysis identified right hepatectomy as a significant independent risk factor for MPV thrombosis (odds ratio 108.9; p < 0.001). Patients with PPV thrombosis had a significantly longer duration of Pringle maneuver than patients without PVT (p = 0.002). Among patients who underwent right hepatectomy, those with PVT (n = 6) had a significantly lower early liver regeneration rate than those without PVT (n = 13; p = 0.040), and those with PVT had deterioration of liver function on postoperative day 7. In all patients with MPV thrombosis who received anticoagulation therapy, PVT subsequently resolved. Conclusions: Postoperative PVT after hepatectomy is not rare. It is closely related to delayed recovery of liver function and delayed liver regeneration.

Original languageEnglish
Pages (from-to)1491-1497
Number of pages7
JournalWorld journal of surgery
Volume38
Issue number6
DOIs
Publication statusPublished - Jun 2014

All Science Journal Classification (ASJC) codes

  • Surgery

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    Yoshiya, S., Shirabe, K., Nakagawara, H., Soejima, Y., Yoshizumi, T., Ikegami, T., Yamashita, Y. I., Harimoto, N., Nishie, A., Yamanaka, T., & Maehara, Y. (2014). Portal vein thrombosis after hepatectomy. World journal of surgery, 38(6), 1491-1497. https://doi.org/10.1007/s00268-013-2440-8